PMID- 28779855
OWN - NLM
STAT- MEDLINE
DCOM- 20180928
LR  - 20220409
IS  - 2352-3018 (Electronic)
IS  - 2352-3018 (Linking)
VI  - 4
IP  - 11
DP  - 2017 Nov
TI  - Progress of UNAIDS 90-90-90 targets in a district in KwaZulu-Natal, South Africa, 
      with high HIV burden, in the HIPSS study: a household-based complex multilevel 
      community survey.
PG  - e505-e513
LID - S2352-3018(17)30122-4 [pii]
LID - 10.1016/S2352-3018(17)30122-4 [doi]
AB  - BACKGROUND: With the goal of eliminating new HIV infections, UNAIDS set the 
      ambitious 90-90-90 targets to be achieved by 2020. We assessed whether these 
      targets are being met among participants of the HIV Incidence Provincial 
      Surveillance System (HIPSS) in a high-burden district of South Africa. METHODS: 
      We used data from a HIPSS household-based, cross-sectional survey of HIV 
      prevalence and incidence done in the uMgungundlovu district, KwaZulu-Natal, in 
      2014 and 2015. In randomly selected enumeration areas, 50 households were drawn 
      systematically along a serpentine pattern from a random start point. One eligible 
      individual in each household was asked to provide blood for HIV testing and to 
      complete a questionnaire. If a household refused to participate, the house next 
      to it was approached. Eligible participants were aged 15-49 years, lived in the 
      household, were not planning to move away, and spoke English or Zulu. Viral load 
      was measured in samples positive for HIV. We also assessed participants' HIV 
      linkage to care and treatment. Data were population weighted to allow for 
      multilevel sampling and non-response. FINDINGS: 9812 participants were enrolled, 
      3547 men (36%) and 6265 women (64%). Overall, 504 of 1014 men (estimate 52%, 95% 
      CI 47-56) and 1833 of 2955 women (65%, 62-67) who were HIV positive knew their 
      HIV status. Of those who knew, 344 of 522 men (69%, 63-75) and 1254 of 1845 women 
      (70%, 68-73) were taking ART. Among recipients of ART, 294 of 341 men (85%, 
      80-90) and 1117 of 1249 women (90%, 87-92) had viral loads less than 1000 copies 
      per mL. Among all HIV-positive participants, 427 of 1014 men (44%, 39-49) and 
      1680 of 2955 women (58%, 55-61) had viral loads lower than 1000 copies per mL. 
      INTERPRETATION: No UNAIDS 90-90-90 targets had been met in our study population. 
      Major campaigns are needed to increase HIV testing, especially among men, and to 
      ensure all HIV-positive patients are taking ART. FUNDING: Centers for Disease 
      Control and Prevention and the US Presidents Emergency Plan for AIDS Relief 
      (PEPFAR).
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Grobler, Anneke
AU  - Grobler A
AD  - Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, 
      South Africa; Clinical Epidemiology and Biostatistics Unit, Murdoch Children's 
      Research Institute, Melbourne, VIC, Australia. Electronic address: 
      caprisa@caprisa.org.
FAU - Cawood, Cherie
AU  - Cawood C
AD  - Epicentre AIDS Risk Management (Pty) Limited, Paarl, South Africa.
FAU - Khanyile, David
AU  - Khanyile D
AD  - Epicentre AIDS Risk Management (Pty) Limited, Paarl, South Africa.
FAU - Puren, Adrian
AU  - Puren A
AD  - Centre for HIV and STIs, National Institute for Communicable Diseases, National 
      Health Laboratory Service (NICD/NHLS), Johannesburg, South Africa; Division of 
      Virology, School of Pathology, University of Witwatersrand, Johannesburg, South 
      Africa.
FAU - Kharsany, Ayesha B M
AU  - Kharsany ABM
AD  - Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, 
      South Africa.
LA  - eng
GR  - CC/CDC HHS/United States
PT  - Journal Article
DEP - 20170802
PL  - Netherlands
TA  - Lancet HIV
JT  - The lancet. HIV
JID - 101645355
RN  - 0 (Anti-HIV Agents)
SB  - IM
CIN - Lancet HIV. 2017 Nov;4(11):e479-e480. PMID: 28779854
MH  - Adolescent
MH  - Adult
MH  - Anti-HIV Agents/therapeutic use
MH  - CD4 Lymphocyte Count
MH  - Cohort Studies
MH  - Cost of Illness
MH  - Cross-Sectional Studies
MH  - Disease Eradication/methods/*statistics & numerical data
MH  - *Family Characteristics
MH  - Female
MH  - HIV Infections/drug therapy/*epidemiology/prevention & control/virology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Mass Screening
MH  - Middle Aged
MH  - Prevalence
MH  - South Africa/epidemiology
MH  - Surveys and Questionnaires
MH  - United Nations
MH  - Viral Load
MH  - Young Adult
EDAT- 2017/08/07 06:00
MHDA- 2018/10/03 06:00
CRDT- 2017/08/07 06:00
PHST- 2016/08/05 00:00 [received]
PHST- 2017/06/09 00:00 [revised]
PHST- 2017/06/13 00:00 [accepted]
PHST- 2017/08/07 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2017/08/07 06:00 [entrez]
AID - S2352-3018(17)30122-4 [pii]
AID - 10.1016/S2352-3018(17)30122-4 [doi]
PST - ppublish
SO  - Lancet HIV. 2017 Nov;4(11):e505-e513. doi: 10.1016/S2352-3018(17)30122-4. Epub 
      2017 Aug 2.