PMID- 28780397
OWN - NLM
STAT- MEDLINE
DCOM- 20180706
LR  - 20231213
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 73
DP  - 2017 Oct
TI  - Neonatal exposure to a glyphosate-based herbicide alters uterine decidualization 
      in rats.
PG  - 87-95
LID - S0890-6238(17)30255-1 [pii]
LID - 10.1016/j.reprotox.2017.07.022 [doi]
AB  - We investigated whether defective modulation of uterine signaling may cause 
      decidualization failure in rats neonatally exposed to a glyphosate-based 
      herbicide (GBH). Female pups received vehicle or 2mg/kg of GBH from postnatal day 
      (PND) 1 to PND7. On PND8 and PND21, Wnt5a and beta-catenin expression was evaluated 
      in uterine samples. On gestational day (GD) 9, Wnt5a, Wnt7a and beta-catenin 
      expression and Dkk1 and sFRP4 mRNA were evaluated on implantation sites. On PND8, 
      GBH-exposed rats showed increased Wnt5a and beta-catenin expression in luminal 
      epithelium (LE), whereas on PND21, they showed increased Wnt5a and beta-catenin 
      expression in subepithelial stroma but decreased beta-catenin expression in 
      glandular epithelium. On GD9, GBH-exposed rats showed decreased Wnt5a and Wnt7a 
      expression in the antimesometrial zone and LE respectively, without changes in 
      beta-catenin expression, while Dkk1 and sFRP4 were up- and down-regulated 
      respectively. We concluded that neonatal GBH exposure may lead to embryo losses 
      by disturbing uterine signaling.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Ingaramo, Paola I
AU  - Ingaramo PI
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas, Santa Fe, Argentina.
FAU - Varayoud, Jorgelina
AU  - Varayoud J
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas, Santa Fe, Argentina.
FAU - Milesi, Maria M
AU  - Milesi MM
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas, Santa Fe, Argentina.
FAU - Guerrero Schimpf, Marlise
AU  - Guerrero Schimpf M
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas, Santa Fe, Argentina.
FAU - Alarcon, Ramiro
AU  - Alarcon R
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas, Santa Fe, Argentina.
FAU - Munoz-de-Toro, Monica
AU  - Munoz-de-Toro M
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas, Santa Fe, Argentina.
FAU - Luque, Enrique H
AU  - Luque EH
AD  - Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquimica y 
      Ciencias Biologicas, Universidad Nacional del Litoral - Consejo Nacional de 
      Investigaciones Cientificas y Tecnicas, Santa Fe, Argentina. Electronic address: 
      eluque@fbcb.unl.edu.ar.
LA  - eng
PT  - Journal Article
DEP - 20170802
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Ctnnb1 protein, rat)
RN  - 0 (Dkk1 protein, rat)
RN  - 0 (Herbicides)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Ribosomal Proteins)
RN  - 0 (Sfrp4 protein, rat)
RN  - 0 (Wnt Proteins)
RN  - 0 (Wnt-5a Protein)
RN  - 0 (Wnt5a protein, rat)
RN  - 0 (Wnt7a protein, rat)
RN  - 0 (beta Catenin)
RN  - 107498-06-6 (Rpl19 protein, rat)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Animals
MH  - Female
MH  - Glycine/*analogs & derivatives/toxicity
MH  - Herbicides/*toxicity
MH  - Intercellular Signaling Peptides and Proteins/genetics
MH  - Maternal-Fetal Exchange
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Proto-Oncogene Proteins/genetics/metabolism
MH  - Rats, Wistar
MH  - Ribosomal Proteins/genetics
MH  - Signal Transduction/drug effects
MH  - Uterus/*drug effects/metabolism
MH  - Wnt Proteins/metabolism
MH  - Wnt-5a Protein/metabolism
MH  - beta Catenin/metabolism
MH  - Glyphosate
OTO - NOTNLM
OT  - Decidualization
OT  - Dkk1
OT  - Glyphosate-based herbicide
OT  - Implantation sites
OT  - Wnt5a
OT  - Wnt7a
OT  - sFRP4
OT  - beta-catenin
EDAT- 2017/08/07 06:00
MHDA- 2018/07/07 06:00
CRDT- 2017/08/07 06:00
PHST- 2017/05/17 00:00 [received]
PHST- 2017/07/25 00:00 [revised]
PHST- 2017/07/27 00:00 [accepted]
PHST- 2017/08/07 06:00 [pubmed]
PHST- 2018/07/07 06:00 [medline]
PHST- 2017/08/07 06:00 [entrez]
AID - S0890-6238(17)30255-1 [pii]
AID - 10.1016/j.reprotox.2017.07.022 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2017 Oct;73:87-95. doi: 10.1016/j.reprotox.2017.07.022. Epub 2017 
      Aug 2.