PMID- 28780967
OWN - NLM
STAT- MEDLINE
DCOM- 20180531
LR  - 20210109
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Linking)
VI  - 82
IP  - 10
DP  - 2017 Nov 15
TI  - Cell- and Single Molecule-Based Methods to Detect Anti-N-Methyl-D-Aspartate 
      Receptor Autoantibodies in Patients With First-Episode Psychosis From the 
      OPTiMiSE Project.
PG  - 766-772
LID - S0006-3223(17)31714-6 [pii]
LID - 10.1016/j.biopsych.2017.06.015 [doi]
AB  - Circulating autoantibodies against glutamatergic N-methyl-D-aspartate receptor 
      (NMDAR) have been reported in a proportion of patients with psychotic disorders, 
      raising hopes for more appropriate treatment for these antibody-positive 
      patients. However, the prevalence of circulating autoantibodies against 
      glutamatergic NMDAR in psychotic disorders remains controversial, with detection 
      prevalence rates and immunoglobulin classes varying considerably between studies, 
      perhaps because of different detection methods. Here, we compared the results of 
      serum assays for a large cohort of patients with first-episode psychosis using 
      classical cell-based assays in three labs and a single molecule-based imaging 
      method. Most assays and single molecule imaging in live hippocampal neurons 
      revealed the presence of circulating autoantibodies against glutamatergic NMDAR 
      in approximately 5% of patients with first-episode psychosis. However, some 
      heterogeneity between cell-based assays was clearly observed, highlighting the 
      urgent need for new sensitive methods to detect the presence of low-titer 
      autoantibodies against glutamatergic NMDAR in seropositive patients who cannot be 
      clinically identified from seronegative ones.
CI  - Copyright (c) 2017. Published by Elsevier Inc.
FAU - Jezequel, Julie
AU  - Jezequel J
AD  - Interdisciplinary Institute for Neuroscience, UMR 5297, University of Bordeaux, 
      France; Centre National de la Recherche Scientifique, France.
FAU - Rogemond, Veronique
AU  - Rogemond V
AD  - Institut NeuroMyoGene, Institut National de la Sante et de la Recherche Medicale 
      U1217/Centre National de la Recherche Scientifique UMR 5310, Lyon, France; 
      Hopital Neurologique, France.
FAU - Pollak, Thomas
AU  - Pollak T
AD  - King's Health Partners, Institute of Psychiatry, Psychology and Neuroscience, 
      King's College London, London, UK.
FAU - Lepleux, Marilyn
AU  - Lepleux M
AD  - Interdisciplinary Institute for Neuroscience, UMR 5297, University of Bordeaux, 
      France; Centre National de la Recherche Scientifique, France.
FAU - Jacobson, Leslie
AU  - Jacobson L
AD  - Nuffield Department of Clinical Neurosciences, Neurosciences Group, Weatherall 
      Institute of Molecular Medicine, University of Oxford, Oxford, UK.
FAU - Grea, Helene
AU  - Grea H
AD  - Interdisciplinary Institute for Neuroscience, UMR 5297, University of Bordeaux, 
      France; Centre National de la Recherche Scientifique, France.
FAU - Iyegbe, Conrad
AU  - Iyegbe C
AD  - King's Health Partners, Institute of Psychiatry, Psychology and Neuroscience, 
      King's College London, London, UK.
FAU - Kahn, Rene
AU  - Kahn R
AD  - Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center 
      Utrecht, Utrecht, The Netherlands.
FAU - McGuire, Philip
AU  - McGuire P
AD  - King's Health Partners, Institute of Psychiatry, Psychology and Neuroscience, 
      King's College London, London, UK.
FAU - Vincent, Angela
AU  - Vincent A
AD  - Nuffield Department of Clinical Neurosciences, Neurosciences Group, Weatherall 
      Institute of Molecular Medicine, University of Oxford, Oxford, UK.
FAU - Honnorat, Jerome
AU  - Honnorat J
AD  - Institut NeuroMyoGene, Institut National de la Sante et de la Recherche Medicale 
      U1217/Centre National de la Recherche Scientifique UMR 5310, Lyon, France; 
      Hopital Neurologique, France.
FAU - Leboyer, Marion
AU  - Leboyer M
AD  - Department of Psychiatry, University Paris Est Creteil, Hopitaux Universitaires 
      Henri Mondor, AP-HP, DHU PePSY, Creteil, France; FondaMental Foundation, Creteil, 
      France.
FAU - Groc, Laurent
AU  - Groc L
AD  - Interdisciplinary Institute for Neuroscience, UMR 5297, University of Bordeaux, 
      France; Centre National de la Recherche Scientifique, France. Electronic address: 
      laurent.groc@u-bordeaux.fr.
LA  - eng
GR  - MR/N026063/1/MRC_/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
DEP - 20170706
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Adult
MH  - Autoantibodies/*analysis/*immunology
MH  - Cells, Cultured
MH  - Female
MH  - Fluoroimmunoassay/*methods
MH  - Hippocampus/cytology
MH  - Humans
MH  - Male
MH  - Neurons/*cytology/*immunology
MH  - Psychotic Disorders/*immunology
MH  - Receptors, N-Methyl-D-Aspartate/*immunology
MH  - Single Molecule Imaging/*methods
MH  - Young Adult
OTO - NOTNLM
OT  - Autoantibodies
OT  - Autoimmunity
OT  - Detection
OT  - Glutamate
OT  - Psychosis
OT  - Schizophrenia
OT  - Single molecule
OT  - Synapse
EDAT- 2017/08/07 06:00
MHDA- 2018/06/01 06:00
CRDT- 2017/08/08 06:00
PHST- 2017/02/02 00:00 [received]
PHST- 2017/06/14 00:00 [revised]
PHST- 2017/06/14 00:00 [accepted]
PHST- 2017/08/07 06:00 [pubmed]
PHST- 2018/06/01 06:00 [medline]
PHST- 2017/08/08 06:00 [entrez]
AID - S0006-3223(17)31714-6 [pii]
AID - 10.1016/j.biopsych.2017.06.015 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2017 Nov 15;82(10):766-772. doi: 10.1016/j.biopsych.2017.06.015. 
      Epub 2017 Jul 6.