PMID- 2878129
OWN - NLM
STAT- MEDLINE
DCOM- 19870106
LR  - 20190611
IS  - 0140-6736 (Print)
IS  - 0140-6736 (Linking)
VI  - 2
IP  - 8518
DP  - 1986 Nov 29
TI  - Serological markers in early stages of human immunodeficiency virus infection in 
      haemophiliacs.
PG  - 1233-6
AB  - Immunoassays for human immunodeficiency virus antigen (HIV Ag) and for antibody 
      to HIV core and envelope (CIA-RA) were done on serial specimens from 40 
      haemophiliacs who had become seropositive on screening by enzyme-linked 
      immunosorbent assay (ELISA). HIV Ag was detectable in 9 subjects and antibodies 
      to envelope in 11 subjects before ELISA seroconversion. The apparent sequence of 
      markers is HIV Ag, antibody to envelope, then antibody to core. Antigenaemia 
      could be detected as soon as 2 weeks after infection and lasted 3-5 months. 82% 
      agreement was seen between CIA-RA and western blot; CIA was more sensitive to 
      envelope antibody and western blot was more sensitive to core antibody.
FAU - Allain, J P
AU  - Allain JP
FAU - Laurian, Y
AU  - Laurian Y
FAU - Paul, D A
AU  - Paul DA
FAU - Senn, D
AU  - Senn D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
RN  - 0 (Viral Core Proteins)
RN  - 0 (Viral Envelope Proteins)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*diagnosis
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Viral/analysis
MH  - Antigens, Viral/analysis
MH  - Child
MH  - Enzyme-Linked Immunosorbent Assay
MH  - HIV/immunology
MH  - Hemophilia A/*complications
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Time Factors
MH  - Viral Core Proteins/immunology
MH  - Viral Envelope Proteins/immunology
EDAT- 1986/11/29 00:00
MHDA- 1986/11/29 00:01
CRDT- 1986/11/29 00:00
PHST- 1986/11/29 00:00 [pubmed]
PHST- 1986/11/29 00:01 [medline]
PHST- 1986/11/29 00:00 [entrez]
AID - S0140-6736(86)92673-5 [pii]
AID - 10.1016/s0140-6736(86)92673-5 [doi]
PST - ppublish
SO  - Lancet. 1986 Nov 29;2(8518):1233-6. doi: 10.1016/s0140-6736(86)92673-5.