PMID- 28781621
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 14
IP  - 2
DP  - 2017 Aug
TI  - Ginsenoside Rg1 prevents starvation-induced muscle protein degradation via 
      regulation of AKT/mTOR/FoxO signaling in C2C12 myotubes.
PG  - 1241-1247
LID - 10.3892/etm.2017.4615 [doi]
AB  - Skeletal muscle atrophy is often caused by catabolic conditions including 
      fasting, disuse, aging and chronic diseases, such as chronic obstructive 
      pulmonary disease. Atrophy occurs when the protein degradation rate exceeds the 
      rate of protein synthesis. Therefore, maintaining a balance between the synthesis 
      and degradation of protein in muscle cells is a major way to prevent skeletal 
      muscle atrophy. Ginsenoside Rg1 (Rg1) is a primary active ingredient in Panax 
      ginseng, which is considered to be one of the most valuable herbs in traditional 
      Chinese medicine. In the current study, Rg1 was observed to inhibit the 
      expression of MuRF-1 and atrogin-1 in C2C12 muscle cells in a starvation model. 
      Rg1 also activated the phosphorylation of mammalian target of rapamycin (mTOR), 
      protein kinase B (AKT), and forkhead transcription factor O, subtypes 1 and 3a. 
      This phosphorylation was inhibited by LY294002, a phosphatidylinositol 3-kinase 
      inhibitor. These data suggest that Rg1 may participate in the regulation of the 
      balance between protein synthesis and degradation, and that the function of Rg1 
      is associated with the AKT/mTOR/FoxO signaling pathway.
FAU - Li, Fengyu
AU  - Li F
AD  - Laboratory of Molecular and Cellular Physiology, School of Life Science, 
      Northeast Normal University, Changchun, Jilin 130024, P.R. China.
FAU - Li, Xiaoxue
AU  - Li X
AD  - Laboratory of Molecular and Cellular Physiology, School of Life Science, 
      Northeast Normal University, Changchun, Jilin 130024, P.R. China.
FAU - Peng, Xuewei
AU  - Peng X
AD  - Laboratory of Molecular and Cellular Physiology, School of Life Science, 
      Northeast Normal University, Changchun, Jilin 130024, P.R. China.
FAU - Sun, Lili
AU  - Sun L
AD  - Laboratory of Molecular and Cellular Physiology, School of Life Science, 
      Northeast Normal University, Changchun, Jilin 130024, P.R. China.
FAU - Jia, Shengnan
AU  - Jia S
AD  - Laboratory of Molecular and Cellular Physiology, School of Life Science, 
      Northeast Normal University, Changchun, Jilin 130024, P.R. China.
FAU - Wang, Ping
AU  - Wang P
AD  - Laboratory of Molecular and Cellular Physiology, School of Life Science, 
      Northeast Normal University, Changchun, Jilin 130024, P.R. China.
FAU - Ma, Shuang
AU  - Ma S
AD  - Laboratory of Molecular and Cellular Physiology, School of Life Science, 
      Northeast Normal University, Changchun, Jilin 130024, P.R. China.
FAU - Zhao, Hongyan
AU  - Zhao H
AD  - Laboratory of Molecular and Cellular Physiology, School of Life Science, 
      Northeast Normal University, Changchun, Jilin 130024, P.R. China.
FAU - Yu, Qingmiao
AU  - Yu Q
AD  - Laboratory of Molecular and Cellular Physiology, School of Life Science, 
      Northeast Normal University, Changchun, Jilin 130024, P.R. China.
FAU - Huo, Hongliang
AU  - Huo H
AD  - Laboratory of Molecular and Cellular Physiology, School of Life Science, 
      Northeast Normal University, Changchun, Jilin 130024, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170615
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5526193
OTO - NOTNLM
OT  - C2C12
OT  - ginsenoside Rg1
OT  - proteolysis
OT  - ubiquitin
EDAT- 2017/08/07 06:00
MHDA- 2017/08/07 06:01
PMCR- 2017/06/15
CRDT- 2017/08/08 06:00
PHST- 2015/08/03 00:00 [received]
PHST- 2016/12/19 00:00 [accepted]
PHST- 2017/08/08 06:00 [entrez]
PHST- 2017/08/07 06:00 [pubmed]
PHST- 2017/08/07 06:01 [medline]
PHST- 2017/06/15 00:00 [pmc-release]
AID - ETM-0-0-4615 [pii]
AID - 10.3892/etm.2017.4615 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 Aug;14(2):1241-1247. doi: 10.3892/etm.2017.4615. Epub 2017 Jun 
      15.