PMID- 28781662
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220113
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 14
IP  - 2
DP  - 2017 Aug
TI  - High expression levels of Wnt5a and Ror2 in laryngeal squamous cell carcinoma are 
      associated with poor prognosis.
PG  - 2232-2238
LID - 10.3892/ol.2017.6386 [doi]
AB  - The present study investigated the prognostic significance of Wnt family member 
      5a (Wnt5a) and receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression 
      in laryngeal squamous cell carcinoma (LSCC). The protein expression levels of 
      Wnt5a and Ror2 were analyzed in specimens from 137 patients with LSCC, using 
      immunohistochemical staining of tissue microarrays and pairs of LSCC and adjacent 
      tissue samples, and examined the associations between the two markers and various 
      clinicopathological parameters. The Wnt5a and Ror2 expression levels were 
      significantly higher in LSCC tissues than in normal tissue samples (Wnt5a, 
      P=0.015; Ror2, P=0.039), and were significantly associated with high tumor stage 
      (P<0.001), lymph node metastasis (Wnt5a, P=0.029; Ror2, P=0.018), and with each 
      other (P=0.002). Patients with LSCC with high Wnt5a or Ror2 expression had poorer 
      prognosis compared with those with low Wnt5a (P=0.022) or Ror2 (P=0.038) 
      expression. Thus, Wnt5a and Ror2 may affect LSCC development, and are potential 
      biomarkers in LSCC.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Otorhinolaryngology, Affiliated Hospital of Nantong University, 
      Nantong, Jiangsu 226001, P.R. China.
FAU - Yan, Yongbing
AU  - Yan Y
AD  - Department of Otorhinolaryngology, Affiliated Hospital of Nantong University, 
      Nantong, Jiangsu 226001, P.R. China.
FAU - Gu, Miao
AU  - Gu M
AD  - Department of Otorhinolaryngology, Affiliated Hospital of Nantong University, 
      Nantong, Jiangsu 226001, P.R. China.
FAU - Wang, Xudong
AU  - Wang X
AD  - Department of Surgical Comprehensive Laboratory, Affiliated Hospital of Nantong 
      University, Nantong, Jiangsu 226001, P.R. China.
FAU - Zhu, Huijun
AU  - Zhu H
AD  - Department of Clinical Pathology, Affiliated Hospital of Nantong University, 
      Nantong, Jiangsu 226001, P.R. China.
FAU - Zhang, Shu
AU  - Zhang S
AD  - Department of Clinical Pathology, Affiliated Hospital of Nantong University, 
      Nantong, Jiangsu 226001, P.R. China.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Clinical Pathology, Affiliated Hospital of Nantong University, 
      Nantong, Jiangsu 226001, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170615
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5530173
OTO - NOTNLM
OT  - Wnt family member 5a
OT  - immunohistochemistry
OT  - laryngeal squamous cell carcinoma
OT  - prognosis
OT  - receptor tyrosine kinase-like orphan receptor 2
EDAT- 2017/08/07 06:00
MHDA- 2017/08/07 06:01
PMCR- 2017/06/15
CRDT- 2017/08/08 06:00
PHST- 2015/09/09 00:00 [received]
PHST- 2017/03/30 00:00 [accepted]
PHST- 2017/08/08 06:00 [entrez]
PHST- 2017/08/07 06:00 [pubmed]
PHST- 2017/08/07 06:01 [medline]
PHST- 2017/06/15 00:00 [pmc-release]
AID - OL-0-0-6386 [pii]
AID - 10.3892/ol.2017.6386 [doi]
PST - ppublish
SO  - Oncol Lett. 2017 Aug;14(2):2232-2238. doi: 10.3892/ol.2017.6386. Epub 2017 Jun 
      15.