PMID- 28781783
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2049-9450 (Print)
IS  - 2049-9469 (Electronic)
IS  - 2049-9450 (Linking)
VI  - 7
IP  - 2
DP  - 2017 Aug
TI  - Neuroendocrine carcinoma of the lung expressing anaplastic lymphoma kinase on 
      high-sensitivity immunohistochemistry: A case report.
PG  - 188-192
LID - 10.3892/mco.2017.1308 [doi]
AB  - It has been reported that anaplastic lymphoma kinase (ALK) protein is expressed 
      in a proportion of non-small-cell carcinomas (mainly adenocarcinomas). By 
      contrast, high-sensitivity immunohistochemistry (IHC) rarely detects ALK protein 
      expression in neuroendocrine carcinomas (NECs) of the lung, which include 
      small-cell carcinomas and large-cell neuroendocrine carcinomas (LCNECs). We 
      herein present a case of NEC that was identified as ALK-positive via 
      high-sensitivity IHC. A 51-year-old man was diagnosed with small-cell carcinoma 
      in the upper lobe of the right lung. Although high-sensitivity IHC revealed that 
      the tumor weakly expressed the ALK protein, no fusion gene with ALK was found 
      using fluorescence in situ hybridization (FISH). Standard chemotherapy was 
      administered to the patient. Six months after the first visit to the hospital for 
      the tumor, another tumor was identified in the upper lobe of the left lung. The 
      tumor was resected and diagnosed as NEC displaying LCNEC-like characteristics. 
      This NEC also moderately expressed ALK protein by high-sensitivity IHC, without 
      exhibiting fusion genes with ALK on FISH. These data suggest that the presence of 
      ALK fusion genes should be confirmed by FISH or reverse transcription polymerase 
      chain reaction, even if high-sensitivity IHC for ALK protein is positive in lung 
      cancer.
FAU - Miyoshi, Kotoko
AU  - Miyoshi K
AD  - Department of Respiratory Medicine, Toyooka Hospital, Toyooka, Hyogo, Japan.
FAU - Adachi, Yasushi
AU  - Adachi Y
AD  - Department of Diagnostic Pathology, Toyooka Hospital, Toyooka, Hyogo, Japan.
AD  - Department of Stem Cell Disorders, Kansai Medical University, Hirakata, Osaka, 
      Japan.
AD  - Department of Pediatrics, Kansai Medical University, Hirakata, Osaka, Japan.
FAU - Nakaji, Hitoshi
AU  - Nakaji H
AD  - Department of Respiratory Medicine, Toyooka Hospital, Toyooka, Hyogo, Japan.
FAU - Okamura, Akiharu
AU  - Okamura A
AD  - Department of Diagnostic Pathology, Kakogawa Central Hospital, Kakogawa, Hyogo, 
      Japan.
FAU - Sakai, Yasuhiro
AU  - Sakai Y
AD  - Department of Diagnostic Pathology, Kobe University Graduate School of 
      Medicine/School of Medicine, Kobe, Hyogo, Japan.
FAU - Hirano, Ryuji
AU  - Hirano R
AD  - Division of Thoracic and Cardiovascular Surgery, Toyooka Hospital, Toyooka, 
      Hyogo, Japan.
FAU - Yahata, Shinsuke
AU  - Yahata S
AD  - Department of Internal General Medicine, Hamasaka Public Hospital, Hamasaka, 
      Hyogo, Japan.
FAU - Li, Ming
AU  - Li M
AD  - Department of Stem Cell Disorders, Kansai Medical University, Hirakata, Osaka, 
      Japan.
AD  - Department of Laboratory for Cardiovascular Disease, Novel, Non-invasive and 
      Nutritional Therapeutics (CNT), Osaka University, Suita, Osaka, Japan.
FAU - Ikehara, Susumu
AU  - Ikehara S
AD  - Department of Stem Cell Disorders, Kansai Medical University, Hirakata, Osaka, 
      Japan.
AD  - Kansai Medical University, Hirakata, Osaka, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170629
PL  - England
TA  - Mol Clin Oncol
JT  - Molecular and clinical oncology
JID - 101613422
PMC - PMC5532692
OTO - NOTNLM
OT  - anaplastic lymphoma kinase
OT  - high-sensitivity immunohistochemistry
OT  - lung
OT  - neuroendocrine carcinoma
EDAT- 2017/08/07 06:00
MHDA- 2017/08/07 06:01
PMCR- 2017/06/29
CRDT- 2017/08/08 06:00
PHST- 2016/11/09 00:00 [received]
PHST- 2017/03/29 00:00 [accepted]
PHST- 2017/08/08 06:00 [entrez]
PHST- 2017/08/07 06:00 [pubmed]
PHST- 2017/08/07 06:01 [medline]
PHST- 2017/06/29 00:00 [pmc-release]
AID - MCO-0-0-1308 [pii]
AID - 10.3892/mco.2017.1308 [doi]
PST - ppublish
SO  - Mol Clin Oncol. 2017 Aug;7(2):188-192. doi: 10.3892/mco.2017.1308. Epub 2017 Jun 
      29.