PMID- 28783743
OWN - NLM
STAT- MEDLINE
DCOM- 20171006
LR  - 20240326
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 8
DP  - 2017
TI  - Andrographis paniculata (Chuan Xin Lian) for symptomatic relief of acute 
      respiratory tract infections in adults and children: A systematic review and 
      meta-analysis.
PG  - e0181780
LID - 10.1371/journal.pone.0181780 [doi]
LID - e0181780
AB  - INTRODUCTION: Antimicrobial resistance (AMR) is a substantial threat to public 
      health. Safe and effective alternatives are required to reduce unnecessary 
      antibiotic prescribing. Andrographis Paniculata (A. Paniculata, Chuan Xin Lian) 
      has traditionally been used in Indian and Chinese herbal medicine for cough, cold 
      and influenza, suggesting a role in respiratory tract infections (RTIs). This 
      systematic review aimed to evaluate the clinical effectiveness and safety of A. 
      Paniculata for symptoms of acute RTIs (ARTIs). MATERIALS AND METHODS: English and 
      Chinese databases were searched from their inception to March 2016 for randomised 
      controlled trials (RCTs) evaluating oral A. Paniculata without language barriers 
      (Protocol ID: CRD42016035679). The primary outcomes were improvement in ARTI 
      symptoms and adverse events (AEs). A random effects model was used to pool the 
      mean differences and risk ratio with 95% CI reported. Methodological quality was 
      evaluated using the Cochrane risk of bias tool; two reviewers independently 
      screened eligibility and extracted data. RESULTS: Thirty-three RCTs (7175 
      patients) were included. Most trials evaluated A. Paniculata (as a monotherapy 
      and as a herbal mixture) provided commercially but seldom reported manufacturing 
      or quality control details. A. Paniculata improved cough (n = 596, standardised 
      mean difference SMD: -0.39, 95% confidence interval CI [-0.67, -0.10]) and sore 
      throat (n = 314, SMD: -1.13, 95% CI [-1.37, -0.89]) when compared with placebo. 
      A. Paniculata (alone or plus usual care) has a statistically significant effect 
      in improving overall symptoms of ARTIs when compared to placebo, usual care, and 
      other herbal therapies. Evidence also suggested that A. Paniculata (alone or plus 
      usual care) shortened the duration of cough, sore throat and sick leave/time to 
      resolution when compared versus usual care. No major AEs were reported and minor 
      AEs were mainly gastrointestinal. The methodological quality of included trials 
      was overall poor. CONCLUSIONS: A. Paniculata appears beneficial and safe for 
      relieving ARTI symptoms and shortening time to symptom resolution. However, these 
      findings should be interpreted cautiously owing to poor study quality and 
      heterogeneity. Well-designed trials evaluating the effectiveness and potential to 
      reduce antibiotic use of A. Paniculata are warranted.
FAU - Hu, Xiao-Yang
AU  - Hu XY
AUID- ORCID: 0000-0002-3143-7999
AD  - Primary Care and Population Sciences, Aldermoor Health Centre, Southampton, 
      United Kingdom.
FAU - Wu, Ruo-Han
AU  - Wu RH
AD  - Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese 
      Medicine, Beijing, China.
FAU - Logue, Martin
AU  - Logue M
AD  - Primary Care and Population Sciences, Aldermoor Health Centre, Southampton, 
      United Kingdom.
FAU - Blondel, Clara
AU  - Blondel C
AD  - AgroParisTech, Paris Institute of Technology for Life, Food and Environmental 
      Sciences, Paris, France.
FAU - Lai, Lily Yuen Wan
AU  - Lai LYW
AD  - Primary Care and Population Sciences, Aldermoor Health Centre, Southampton, 
      United Kingdom.
FAU - Stuart, Beth
AU  - Stuart B
AD  - Primary Care and Population Sciences, Aldermoor Health Centre, Southampton, 
      United Kingdom.
FAU - Flower, Andrew
AU  - Flower A
AD  - Primary Care and Population Sciences, Aldermoor Health Centre, Southampton, 
      United Kingdom.
FAU - Fei, Yu-Tong
AU  - Fei YT
AD  - Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese 
      Medicine, Beijing, China.
FAU - Moore, Michael
AU  - Moore M
AD  - Primary Care and Population Sciences, Aldermoor Health Centre, Southampton, 
      United Kingdom.
FAU - Shepherd, Jonathan
AU  - Shepherd J
AD  - Southampton Health Technology Assessments Centre (SHTAC), Faculty of Medicine, 
      University of Southampton, Southampton, United Kingdom.
FAU - Liu, Jian-Ping
AU  - Liu JP
AD  - Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese 
      Medicine, Beijing, China.
FAU - Lewith, George
AU  - Lewith G
AD  - Primary Care and Population Sciences, Aldermoor Health Centre, Southampton, 
      United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20170804
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
EIN - PLoS One. 2018 Nov 14;13(11):e0207713. PMID: 30427943
MH  - Acute Disease
MH  - Adult
MH  - Child
MH  - Drugs, Chinese Herbal/adverse effects/*pharmacology/therapeutic use
MH  - Humans
MH  - Respiratory Tract Infections/*drug therapy
MH  - Safety
PMC - PMC5544222
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/08/08 06:00
MHDA- 2017/10/07 06:00
PMCR- 2017/08/04
CRDT- 2017/08/08 06:00
PHST- 2016/11/08 00:00 [received]
PHST- 2017/07/06 00:00 [accepted]
PHST- 2017/08/08 06:00 [entrez]
PHST- 2017/08/08 06:00 [pubmed]
PHST- 2017/10/07 06:00 [medline]
PHST- 2017/08/04 00:00 [pmc-release]
AID - PONE-D-16-44414 [pii]
AID - 10.1371/journal.pone.0181780 [doi]
PST - epublish
SO  - PLoS One. 2017 Aug 4;12(8):e0181780. doi: 10.1371/journal.pone.0181780. 
      eCollection 2017.