PMID- 28785812
OWN - NLM
STAT- MEDLINE
DCOM- 20180716
LR  - 20220321
IS  - 1861-0692 (Electronic)
IS  - 1861-0684 (Linking)
VI  - 106
IP  - 12
DP  - 2017 Dec
TI  - Functional status and quality of life after transcatheter mitral valve repair: a 
      prospective cohort study and systematic review.
PG  - 1005-1017
LID - 10.1007/s00392-017-1150-x [doi]
AB  - BACKGROUND: Estimating the quantitative effect of transcatheter mitral valve 
      repair on functional parameters and quality of life is important for individual 
      treatment decision-making. METHODS: We combined data from a prospective 
      monocentric cohort study (N = 215) with data from a systematic literature review 
      (PubMed search term "mitraclip", till 30.04.2016) on patients undergoing 
      MitraClip with at least mortality after discharge reported as an outcome. Effects 
      on functional parameters were reported as range of mean change. RESULTS: 36 
      observational studies and 1 randomized controlled trial were identified. Due to 
      substantial heterogeneity of effect estimates (I (2)-heterogeneity >75%) and 
      inadequate quality of studies with a lack of comparison group in 97.4% and lack 
      of an independent assessment of outcomes in 86.8%, no pooled estimates were 
      calculated. All studies reported improvements of mean New York Heart Association 
      (NYHA) class (0.5-1.9 classes), Short-Form (SF)-12/36 scores (4.4-9.2 for 
      physical component score, 2.6-8.9 for mental component score), 6-min walk 
      distance [(6MWD) 2-336 m] and Minnesota Living with Heart failure questionnaire 
      (MLWHFQ) score (-7 to -18 points), with improvements regarded as clinically 
      relevant in 20 of 29 studies for NYHA class, in all of 7 studies for SF12/36, in 
      9 of 15 studies for 6MWD and in all of 8 studies for MLWHFQ. CONCLUSION: 
      MitraClip therapy provides improvements in physical capacity, physical and mental 
      functioning and disease-specific quality of life in the majority of patients. 
      However, more comparative and high-quality studies are required for understanding 
      the heterogeneity of results, which is crucial for optimal patient selection.
FAU - Iliadis, Christos
AU  - Iliadis C
AD  - Department III of Internal Medicine, Heart Center, University of Cologne, 
      Kerpener Str. 62, 50937, Cologne, Germany.
FAU - Lee, Samuel
AU  - Lee S
AD  - Department III of Internal Medicine, Heart Center, University of Cologne, 
      Kerpener Str. 62, 50937, Cologne, Germany.
FAU - Kuhr, Kathrin
AU  - Kuhr K
AD  - Institute of Medical Statistics, Informatics and Epidemiology, University of 
      Cologne, Cologne, Germany.
FAU - Metze, Clemens
AU  - Metze C
AD  - Department III of Internal Medicine, Heart Center, University of Cologne, 
      Kerpener Str. 62, 50937, Cologne, Germany.
FAU - Matzik, Anna-Sophie
AU  - Matzik AS
AD  - Department III of Internal Medicine, Heart Center, University of Cologne, 
      Kerpener Str. 62, 50937, Cologne, Germany.
FAU - Michels, Guido
AU  - Michels G
AD  - Department III of Internal Medicine, Heart Center, University of Cologne, 
      Kerpener Str. 62, 50937, Cologne, Germany.
FAU - Rudolph, Volker
AU  - Rudolph V
AD  - Department III of Internal Medicine, Heart Center, University of Cologne, 
      Kerpener Str. 62, 50937, Cologne, Germany.
FAU - Baldus, Stephan
AU  - Baldus S
AD  - Department III of Internal Medicine, Heart Center, University of Cologne, 
      Kerpener Str. 62, 50937, Cologne, Germany.
FAU - Pfister, Roman
AU  - Pfister R
AUID- ORCID: 0000-0002-4358-5008
AD  - Department III of Internal Medicine, Heart Center, University of Cologne, 
      Kerpener Str. 62, 50937, Cologne, Germany. roman.pfister@uk-koeln.de.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20170807
PL  - Germany
TA  - Clin Res Cardiol
JT  - Clinical research in cardiology : official journal of the German Cardiac Society
JID - 101264123
SB  - IM
MH  - *Heart Valve Prosthesis
MH  - *Hemodynamics
MH  - Humans
MH  - Mitral Valve/*surgery
MH  - *Mitral Valve Insufficiency/physiopathology/psychology/surgery
MH  - Postoperative Period
MH  - Prospective Studies
MH  - *Quality of Life
OTO - NOTNLM
OT  - Functionality
OT  - MitraClip
OT  - Quality of life
EDAT- 2017/08/09 06:00
MHDA- 2018/07/17 06:00
CRDT- 2017/08/09 06:00
PHST- 2017/05/22 00:00 [received]
PHST- 2017/08/02 00:00 [accepted]
PHST- 2017/08/09 06:00 [pubmed]
PHST- 2018/07/17 06:00 [medline]
PHST- 2017/08/09 06:00 [entrez]
AID - 10.1007/s00392-017-1150-x [pii]
AID - 10.1007/s00392-017-1150-x [doi]
PST - ppublish
SO  - Clin Res Cardiol. 2017 Dec;106(12):1005-1017. doi: 10.1007/s00392-017-1150-x. 
      Epub 2017 Aug 7.