PMID- 28786001
OWN - NLM
STAT- MEDLINE
DCOM- 20180606
LR  - 20230722
IS  - 1868-8500 (Electronic)
IS  - 1868-8497 (Print)
IS  - 1868-8497 (Linking)
VI  - 8
IP  - 5-6
DP  - 2017 Dec
TI  - Maternal Resveratrol Treatment Reduces the Risk of Mammary Carcinogenesis in 
      Female Offspring Prenatally Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.
PG  - 286-297
LID - 10.1007/s12672-017-0304-7 [doi]
AB  - 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) presents adverse effects on breast 
      development/carcinogenesis. This study aimed to identify the ability of 
      resveratrol (Res) to modify the adverse effects of TCDD in a female offspring. 
      Pregnant female Wistar rats were allocated into four groups: TCDD, TCDD + Res, 
      Res, and control. TCDD (1 mug/kg) was orally administered as a single dose on 
      gestational day (GD) 15, and Res was orally administered during GD10-21 and 
      lactation at a dose of 20 mg/kg/day. Female offsprings were euthanized on a 
      specific postnatal day (PND) for hormonal analysis (PND 22, 48-51), vaginal 
      opening (PND 30-48), and mammary gland morphology (PND 22). Other females 
      received two doses of N-nitroso-N-methylurea (MNU, 50 mg/kg) on PNDs 22 and 51 
      and were euthanized on PND 24 (Ki-67, ER-alpha and apoptosis indexes or molecular 
      analysis) or PND 180 (tumor assay). TCDD exposure altered the development of the 
      mammary structure while these alterations were partially improved by maternal 
      Res. Two days after first MNU administration, some genes associated with 
      apoptosis were altered in the mammary tissue from the TCDD group (Bax and Caspase 
      3 down- and Bcl-2 upregulated) but were also partially reestablished by maternal 
      Res. Mammary gland bcl-2 and bcl-xl proteins expression was increased while the 
      apoptosis index was reduced by TCDD exposure but restored by maternal Res. An 
      increase in number of mammary tumors was observed in female offspring from the 
      TCDD group compared to the other groups. The results indicate that most mammary 
      changes induced in female offspring through TCDD exposure or after MNU 
      administrations were reduced by maternal resveratrol treatment.
FAU - de Lima E Silva, Tassia C
AU  - de Lima E Silva TC
AD  - Departamento de Enfermagem, Centro Academico de Vitoria, UFPE- Universidade 
      Federal do Pernambuco (UFPE), Vitoria de Santo Antao, PE, 55608-680, Brazil.
AD  - Departamento de Patologia, Faculdade de Medicina de Botucatu, Universidade 
      Estadual Paulista (UNESP), Botucatu, SP, 18610-307, Brazil.
FAU - da Silveira, Livia T R
AU  - da Silveira LTR
AD  - Departamento de Morfologia, Instituto de Biociencias de Botucatu, Universidade 
      Estadual Paulista (UNESP), Botucatu, SP, 18618-689, Brazil.
FAU - Fragoso, Mariana F
AU  - Fragoso MF
AD  - Departamento de Patologia, Faculdade de Medicina de Botucatu, Universidade 
      Estadual Paulista (UNESP), Botucatu, SP, 18610-307, Brazil.
FAU - da Silva, Flavia R M
AU  - da Silva FRM
AD  - Departamento de Patologia, Faculdade de Medicina de Botucatu, Universidade 
      Estadual Paulista (UNESP), Botucatu, SP, 18610-307, Brazil.
FAU - Martinez, Meire F
AU  - Martinez MF
AD  - Departamento de Morfologia, Instituto de Biociencias de Botucatu, Universidade 
      Estadual Paulista (UNESP), Botucatu, SP, 18618-689, Brazil.
FAU - Zapaterini, Joyce R
AU  - Zapaterini JR
AD  - Departamento de Patologia, Faculdade de Medicina de Botucatu, Universidade 
      Estadual Paulista (UNESP), Botucatu, SP, 18610-307, Brazil.
FAU - Diniz, Odair H G
AU  - Diniz OHG
AD  - Departamento de Morfologia, Instituto de Biociencias de Botucatu, Universidade 
      Estadual Paulista (UNESP), Botucatu, SP, 18618-689, Brazil.
FAU - Scarano, Wellerson R
AU  - Scarano WR
AD  - Departamento de Morfologia, Instituto de Biociencias de Botucatu, Universidade 
      Estadual Paulista (UNESP), Botucatu, SP, 18618-689, Brazil.
FAU - Barbisan, Luis F
AU  - Barbisan LF
AD  - Departamento de Morfologia, Instituto de Biociencias de Botucatu, Universidade 
      Estadual Paulista (UNESP), Botucatu, SP, 18618-689, Brazil. 
      barbisan@ibb.unesp.br.
LA  - eng
PT  - Journal Article
DEP - 20170807
PL  - United States
TA  - Horm Cancer
JT  - Hormones & cancer
JID - 101518427
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Hormones)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Stilbenes)
RN  - 0 (Teratogens)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents, Phytogenic/*pharmacology
MH  - Breast Neoplasms/*etiology/pathology/prevention & control
MH  - Cell Transformation, Neoplastic/chemically induced/metabolism/pathology
MH  - Disease Models, Animal
MH  - Female
MH  - Hormones/blood/metabolism
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Polychlorinated Dibenzodioxins/*adverse effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Resveratrol
MH  - Stilbenes/*administration & dosage
MH  - Teratogens/*toxicity
MH  - Tumor Burden
PMC - PMC10355987
COIS- The authors declare that they have no conflict of interest.
EDAT- 2017/08/09 06:00
MHDA- 2018/06/07 06:00
PMCR- 2017/08/07
CRDT- 2017/08/09 06:00
PHST- 2017/05/24 00:00 [received]
PHST- 2017/07/31 00:00 [accepted]
PHST- 2017/08/09 06:00 [pubmed]
PHST- 2018/06/07 06:00 [medline]
PHST- 2017/08/09 06:00 [entrez]
PHST- 2017/08/07 00:00 [pmc-release]
AID - 10.1007/s12672-017-0304-7 [pii]
AID - 304 [pii]
AID - 10.1007/s12672-017-0304-7 [doi]
PST - ppublish
SO  - Horm Cancer. 2017 Dec;8(5-6):286-297. doi: 10.1007/s12672-017-0304-7. Epub 2017 
      Aug 7.