PMID- 28786061
OWN - NLM
STAT- MEDLINE
DCOM- 20180430
LR  - 20181113
IS  - 1993-1352 (Electronic)
IS  - 1672-0733 (Linking)
VI  - 37
IP  - 4
DP  - 2017 Aug
TI  - Association of increased urine brain derived neurotrophic factor with lower 
      urinary tract symptoms in men with benign prostatic hyperplasia.
PG  - 531-535
LID - 10.1007/s11596-017-1768-y [doi]
AB  - Urinary brain-derived neurotrophic factor (BDNF), an ubiquitous neurotrophin, was 
      found to rise in patients with benign prostatic hyperplasia (BPH). We 
      hypothesized that the urinary level of BDNF could be a potential biomarker for 
      lower urinary tract symptoms (LUTS) in patients with BPH. Totally, 76 patients 
      with BPH-caused LUTS and 32 male control subjects without BPH were enrolled. 
      International Prostate Symptom Score (IPSS) was applied to assess the symptom 
      severity of LUTS. Urodynamic tests were performed for the diagnosis of underlying 
      detrusor overactivity (DO) in the patients with BPH. Urine samples were collected 
      from all subjects. Urinary BDNF levels were measured using enzyme-linked 
      immunosorbent assays and normalized by urinary creatinine (Cr) levels. 
      Seventy-six BPH patients were divided into moderate LUTS group (n=51, 7<IPSS</=20) 
      and severe LUTS group (n=25, IPSS>20) according to the IPSS. Of the 76 BPH 
      patients, DO was present in 34 (44.7%) according to the urodynamic test. The 
      urinary BDNF/Cr levels were significantly higher in BPH patients with moderate 
      LUTS (8.29+/-3.635, P<0.0001) and severe LUTS (11.8+/-6.44, P<0.0001) than normal 
      controls (1.71+/-0.555). Patients with severe LUTS tended to have higher urinary 
      BDNF/Cr levels than patients with moderate LUTS (11.8+/-6.44 vs. 8.29+/-3.635, 
      P=0.000). The conditions of BPH with LUTS correlated with elevated urinary BDNF 
      levels, and urinary BDNF levels were even higher in BPH-DO patients. The results 
      of this study have provided evidence to suggest that urinary BDNF level test 
      could evaluate the severity of LUTS in BPH patients, and BDNF level can be used 
      as a biomarker for the diagnosis of DO in BPH patients.
FAU - Wang, Long-Wang
AU  - Wang LW
AD  - Department of Urology, the Second Hospital of Nanchang University, Nanchang, 
      330006, China.
FAU - Li, Jian-Long
AU  - Li JL
AD  - Department of Urology, Xi'an Third Hospital, Xi'an, 710018, China.
FAU - Yu, Yi
AU  - Yu Y
AD  - Department of Urology, the Second Hospital of Nanchang University, Nanchang, 
      330006, China.
FAU - Xiao, Rui-Hai
AU  - Xiao RH
AD  - Department of Urology, the Second Hospital of Nanchang University, Nanchang, 
      330006, China.
FAU - Huang, Hong-Wei
AU  - Huang HW
AD  - Department of Urology, the Second Hospital of Nanchang University, Nanchang, 
      330006, China.
FAU - Kuang, Ren-Rui
AU  - Kuang RR
AD  - Department of Urology, the Second Hospital of Nanchang University, Nanchang, 
      330006, China.
FAU - Hai, Bo
AU  - Hai B
AD  - Department of Urology, Union Hospital, Tongji Medical College, Huazhong 
      Unicersity of Science and Technology, Wuhan, 430022, China. bohai234@yeah.net.
LA  - eng
PT  - Journal Article
DEP - 20170808
PL  - China
TA  - J Huazhong Univ Sci Technolog Med Sci
JT  - Journal of Huazhong University of Science and Technology. Medical sciences = Hua 
      zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. 
      Yixue Yingdewen ban
JID - 101169627
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*urine
MH  - Case-Control Studies
MH  - Creatinine/urine
MH  - Humans
MH  - Lower Urinary Tract Symptoms/*complications/*urine
MH  - Male
MH  - Middle Aged
MH  - Prostatic Hyperplasia/*complications
MH  - Urinary Bladder, Overactive/complications/urine
OTO - NOTNLM
OT  - benign prostatic hyperplasia
OT  - biomarker
OT  - increased urine brain derived neurotrophic factor
OT  - lower urinary tract symptoms
EDAT- 2017/08/09 06:00
MHDA- 2018/05/01 06:00
CRDT- 2017/08/09 06:00
PHST- 2016/08/30 00:00 [received]
PHST- 2017/05/19 00:00 [revised]
PHST- 2017/08/09 06:00 [entrez]
PHST- 2017/08/09 06:00 [pubmed]
PHST- 2018/05/01 06:00 [medline]
AID - 10.1007/s11596-017-1768-y [pii]
AID - 10.1007/s11596-017-1768-y [doi]
PST - ppublish
SO  - J Huazhong Univ Sci Technolog Med Sci. 2017 Aug;37(4):531-535. doi: 
      10.1007/s11596-017-1768-y. Epub 2017 Aug 8.