PMID- 28788205
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1996-1944 (Print)
IS  - 1996-1944 (Electronic)
IS  - 1996-1944 (Linking)
VI  - 7
IP  - 9
DP  - 2014 Sep 16
TI  - Sustained Release of Lidocaine from Solvent-Free Biodegradable 
      Poly[(d,l)-Lactide-co-Glycolide] (PLGA): In Vitro and In Vivo Study.
PG  - 6660-6676
LID - 10.3390/ma7096660 [doi]
AB  - Local anesthetics are commonly used for pain relief by regional nerve blocking. 
      In this study, we fabricated solvent-free biodegradable pellets to extend the 
      duration of lidocaine release without any significant local or systemic toxicity 
      levels. To manufacture the pellets, poly[(d,l)-lactide-co-glycolide] (PLGA) was 
      first pre-mixed with lidocaine powder into different ratios. The powder mixture 
      was then compressed with a mold (diameter of 1, 5, 8 or 10 mm) and sintered at 65 
       degrees C to form pellets. The in vitro release study showed that the lidocaine/PLGA 
      pellets exhibited a tri-phase release behavior (a burst, a diffusion-controlled 
      release and a degradation-dominated release) and reached completion around day 
      28. Scanning electron microscope (SEM) photos show that small channels could be 
      found on the surfaces of the pellets on day 2. Furthermore, the polymer matrix 
      swelled and fell apart on day 7, while the pellets became viscous after 10 days 
      of in vitro elution. Perineural administration of the lidocaine/PLGA pellets 
      produced anti-hypersensitivity effects lasting for at least 24 h in rats, 
      significant when compared to the control group (a pure PLGA was pellet 
      administered). In addition, no inflammation was detected within the nerve and in 
      the neighboring muscle by histopathology.
FAU - Kau, Yi-Chuan
AU  - Kau YC
AD  - Department of Anesthesiology, Chang Gung Memorial Hospital, Tao-Yuan 333, Taiwan. 
      yichuan@cgmh.org.tw.
FAU - Liao, Chia-Chih
AU  - Liao CC
AD  - Department of Anesthesiology, Chang Gung Memorial Hospital, Tao-Yuan 333, Taiwan. 
      m7147@cloud.cgmh.org.tw.
FAU - Chen, Ying-Chi
AU  - Chen YC
AD  - Graduate Institute of Medical Mechatronics, Chang Gung University, Tao-Yuan 333, 
      Taiwan. yingtzai@gmail.com.
FAU - Liu, Shih-Jung
AU  - Liu SJ
AD  - Department of Mechanical Engineering, Chang Gung University, Tao-Yuan 333, 
      Taiwan. shihjung@mail.cgu.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20140916
PL  - Switzerland
TA  - Materials (Basel)
JT  - Materials (Basel, Switzerland)
JID - 101555929
PMC - PMC5456155
OTO - NOTNLM
OT  - biodegradable pellets
OT  - lidocaine
OT  - poly[(d,l)-lactide-co-glycolide] (PLGA)
OT  - sustained release
COIS- The authors declare no conflict of interest.
EDAT- 2014/09/16 00:00
MHDA- 2014/09/16 00:01
PMCR- 2014/09/16
CRDT- 2017/08/10 06:00
PHST- 2014/07/24 00:00 [received]
PHST- 2014/08/19 00:00 [revised]
PHST- 2014/09/09 00:00 [accepted]
PHST- 2017/08/10 06:00 [entrez]
PHST- 2014/09/16 00:00 [pubmed]
PHST- 2014/09/16 00:01 [medline]
PHST- 2014/09/16 00:00 [pmc-release]
AID - ma7096660 [pii]
AID - materials-07-06660 [pii]
AID - 10.3390/ma7096660 [doi]
PST - epublish
SO  - Materials (Basel). 2014 Sep 16;7(9):6660-6676. doi: 10.3390/ma7096660.