PMID- 28788259
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1996-1944 (Print)
IS  - 1996-1944 (Electronic)
IS  - 1996-1944 (Linking)
VI  - 7
IP  - 11
DP  - 2014 Nov 21
TI  - Layer-by-Layer Assembly of Biopolyelectrolytes onto Thermo/pH-Responsive 
      Micro/Nano-Gels.
PG  - 7472-7512
LID - 10.3390/ma7117472 [doi]
AB  - This review deals with the layer-by-layer (LbL) assembly of polyelectrolyte 
      multilayers of biopolymers, polypeptides (i.e., poly-l-lysine/poly-l-glutamic 
      acid) and polysaccharides (i.e., chitosan/dextran sulphate/sodium alginate), onto 
      thermo- and/or pH-responsive micro- and nano-gels such as those based on 
      synthetic poly(N-isopropylacrylamide) (PNIPAM) and poly(acrylic acid) (PAA) or 
      biodegradable hyaluronic acid (HA) and dextran-hydroxyethyl methacrylate 
      (DEX-HEMA). The synthesis of the ensembles and their characterization by way of 
      various techniques is described. The morphology, hydrodynamic size, surface 
      charge density, bilayer thickness, stability over time and mechanical properties 
      of the systems are discussed. Further, the mechanisms of interaction between 
      biopolymers and gels are analysed. Results demonstrate that the structure and 
      properties of biocompatible multilayer films can be finely tuned by confinement 
      onto stimuli-responsive gels, which thus provides new perspectives for biomedical 
      applications, particularly in the controlled release of biomolecules, 
      bio-sensors, gene delivery, tissue engineering and storage.
FAU - Diez-Pascual, Ana M
AU  - Diez-Pascual AM
AD  - Analytical Chemistry, Physical Chemistry and Chemical Engineering Department, 
      Faculty of Biology, Environmental Sciences and Chemistry, Alcala University, 
      28871 Alcala de Henares, Madrid, Spain. am.diez@uah.es.
FAU - Shuttleworth, Peter S
AU  - Shuttleworth PS
AD  - Instituto de Ciencia y Tecnologia de Polimeros-Consejo Superior de 
      Investigaciones Cientificas, Juan de la Cierva 3, 28006 Madrid, Spain. 
      peter@ictp.csic.es.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20141121
PL  - Switzerland
TA  - Materials (Basel)
JT  - Materials (Basel, Switzerland)
JID - 101555929
PMC - PMC5512647
OTO - NOTNLM
OT  - biomedical applications
OT  - layer-by-layer
OT  - polyelectrolytes
OT  - polypeptides
OT  - polysaccharides
OT  - thermoresponsive gels
COIS- The authors declare no conflict of interest.
EDAT- 2014/11/21 00:00
MHDA- 2014/11/21 00:01
PMCR- 2014/11/21
CRDT- 2017/08/10 06:00
PHST- 2014/10/13 00:00 [received]
PHST- 2014/11/01 00:00 [revised]
PHST- 2014/11/14 00:00 [accepted]
PHST- 2017/08/10 06:00 [entrez]
PHST- 2014/11/21 00:00 [pubmed]
PHST- 2014/11/21 00:01 [medline]
PHST- 2014/11/21 00:00 [pmc-release]
AID - ma7117472 [pii]
AID - materials-07-07472 [pii]
AID - 10.3390/ma7117472 [doi]
PST - epublish
SO  - Materials (Basel). 2014 Nov 21;7(11):7472-7512. doi: 10.3390/ma7117472.