PMID- 28788274
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240326
IS  - 1996-1944 (Print)
IS  - 1996-1944 (Electronic)
IS  - 1996-1944 (Linking)
VI  - 7
IP  - 12
DP  - 2014 Dec 4
TI  - Synthesization, Characterization, and in Vitro Evaluation of Cytotoxicity of 
      Biomaterials Based on Halloysite Nanotubes.
PG  - 7770-7780
LID - 10.3390/ma7127770 [doi]
AB  - Halloysite is an aluminosilicate clay that has been widely used for controlled 
      drug delivery, immobilization of enzymes, and for the capture of circulating 
      tumor cells (CTCs). Surface modification of halloysite by organosilanes has been 
      explored to improve their properties. In this study halloysite clay nanotubes 
      (HNTs) were functionalized by two different organosilanes: 
      Trimethoxy(propyl)silane (TMPS), and Triethoxy(octyl)silane (EOS). Untreated and 
      modified samples were characterized by scanning electron microscopy (SEM), X-ray 
      diffractometry (XRD), thermogravimetrical analysis (TGA), and Fourier transform 
      infrared spectroscopy (FTIR). Results showed a strong interaction of 
      organosilanes with the chemical groups present in HNTs. Biocompatibility and 
      cytotoxicity of these nanomaterials were determined using C6 rat glioblastoma 
      cells. Our results indicate that prior to functionalization, HNTs show a high 
      biocompatibility and low cytotoxicity. However, HNTs functionalized with EOS and 
      TMPS showed high cytotoxicity by inducing apoptosis. These results allow the 
      identification of potential applications in biomedical areas for HNTs.
FAU - Sanchez-Fernandez, Antonio
AU  - Sanchez-Fernandez A
AD  - Instituto Tecnologico de Estudios Superiores de Monterrey, Eugenio Garza Sada 
      2501, Col. Tecnologico, 64849 Monterrey, NL, Mexico. asanfer@itesm.mx.
FAU - Pena-Paras, Laura
AU  - Pena-Paras L
AD  - Departamento de Ingenieria, Universidad de Monterrey, Ave. Morones Prieto 4500 
      Pte., Col. Jesus M. Garza, 66238 San Pedro Garza Garcia, NL, Mexico. 
      laura.pena@udem.edu.
FAU - Vidaltamayo, Roman
AU  - Vidaltamayo R
AD  - Departamento de Ciencias Basicas, Universidad de Monterrey, Ave. Morones Prieto 
      4500 Pte., Col. Jesus M. Garza, 66238 San Pedro Garza Garcia, NL, Mexico. 
      roman.vidaltamayo@udem.edu.
FAU - Cue-Sampedro, Rodrigo
AU  - Cue-Sampedro R
AD  - Instituto Tecnologico de Estudios Superiores de Monterrey, Eugenio Garza Sada 
      2501, Col. Tecnologico, 64849 Monterrey, NL, Mexico. 
      rodrigo.cue.sampedro@itesm.mx.
FAU - Mendoza-Martinez, Ana
AU  - Mendoza-Martinez A
AD  - Departamento de Ingenieria, Universidad de Monterrey, Ave. Morones Prieto 4500 
      Pte., Col. Jesus M. Garza, 66238 San Pedro Garza Garcia, NL, Mexico. 
      ana.mendoza@udem.edu.
FAU - Zomosa-Signoret, Viviana C
AU  - Zomosa-Signoret VC
AD  - Departamento de Bioquimica y Medicina Molecular, Facultad de Medicina, 
      Universidad Autonoma de Nuevo Leon, Jesus Aguirre Pequeno esq. Av. Madero, 64460 
      Monterrey, NL, Mexico. vivizomo@gmail.com.
FAU - Rivas-Estilla, Ana M
AU  - Rivas-Estilla AM
AD  - Departamento de Bioquimica y Medicina Molecular, Facultad de Medicina, 
      Universidad Autonoma de Nuevo Leon, Jesus Aguirre Pequeno esq. Av. Madero, 64460 
      Monterrey, NL, Mexico. amrivas1@yahoo.ca.
FAU - Riojas, Paulina
AU  - Riojas P
AD  - Departamento de Ingenieria, Universidad de Monterrey, Ave. Morones Prieto 4500 
      Pte., Col. Jesus M. Garza, 66238 San Pedro Garza Garcia, NL, Mexico. 
      paulina.riojas@udem.edu.
LA  - eng
PT  - Journal Article
DEP - 20141204
PL  - Switzerland
TA  - Materials (Basel)
JT  - Materials (Basel, Switzerland)
JID - 101555929
PMC - PMC5456434
OTO - NOTNLM
OT  - HNTs
OT  - characterization
OT  - cytotoxicity
OT  - functionalization
OT  - organosilanes
COIS- The authors declare no conflict of interest.
EDAT- 2014/12/04 00:00
MHDA- 2014/12/04 00:01
PMCR- 2014/12/04
CRDT- 2017/08/10 06:00
PHST- 2014/08/25 00:00 [received]
PHST- 2014/10/16 00:00 [revised]
PHST- 2014/11/07 00:00 [accepted]
PHST- 2017/08/10 06:00 [entrez]
PHST- 2014/12/04 00:00 [pubmed]
PHST- 2014/12/04 00:01 [medline]
PHST- 2014/12/04 00:00 [pmc-release]
AID - ma7127770 [pii]
AID - materials-07-07770 [pii]
AID - 10.3390/ma7127770 [doi]
PST - epublish
SO  - Materials (Basel). 2014 Dec 4;7(12):7770-7780. doi: 10.3390/ma7127770.