PMID- 28789461
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 14
IP  - 2
DP  - 2017 Aug
TI  - Clinical significance of circulating microparticles in Ph(-) myeloproliferative 
      neoplasms.
PG  - 2531-2536
LID - 10.3892/ol.2017.6459 [doi]
AB  - Microparticles (MPs) are small membrane vesicles that are classified into 
      subcategories based on their origin, such as platelet-derived MPs (PMPs), 
      endothelial MPs (EMPs), red blood cell MPs (RMPs) and tissue factor MPs (TF + 
      MPs). Philadelphia chromosome-negative myeloproliferative neoplasms (Ph(-)MPN) 
      are disorders characterized by abnormal haematopoiesis, thrombosis and the 
      JAK2V617F mutation. MPs are biomarkers for procoagulant state in cancer patients, 
      but their relevance in patients with Ph(-)MPN was unclear. The present study 
      aimed to measure MP variation in MPN patients and evaluate association with the 
      JAK2V617F mutation and with thrombosis and splenomegaly. In total, 92 patients 
      with MPN were enrolled in the present study, including 60 with essential 
      thrombocythaemia (ET), 20 with polycythaemia vera (PV), and 12 with primary 
      myelofibrosis (PMF). RMPs, PMPs, TF + MPs and EMPs were measured by flow 
      cytometry. The levels of RMPs, PMPs, EMPs and TF + MPs in patients with Ph(-)MPN 
      were all found to be significantly increased compared with controls (P<0.05). 
      Additionally, the levels of all four types of MPs in the PMF group were 
      significantly increased compared with the PV group (P<0.05), and the level of 
      RMPs in the PMF group was significantly increased compared with the ET group 
      (P<0.05). MP levels were increased in the Ph(-)MPN patients with thrombosis 
      compared with patients without thrombosis (P<0.05). MP levels were increased in 
      Ph(-)MPN patients with splenomegaly compared with patients without splenomegaly 
      (P<0.05). The level of PMPs in patients with the JAK2V617F mutation was increased 
      compared with patients without the mutation (P<0.05). In conclusion, the present 
      study showed that MPs are associated with Ph(-)MPN pathogenesis, and may promote 
      thrombosis.
FAU - Zhang, Wenjuan
AU  - Zhang W
AD  - Department of Haematology, The First Affiliated Hospital of Soochow University, 
      Jiangsu Institute of Haematology, Suzhou, Jiangsu 215006, P.R. China.
AD  - Soochow University, Collaborative Innovation Centre of Haematology, Suzhou, 
      Jiangsu 215006, P.R. China.
AD  - Key Laboratory of Thrombosis and Haemostasis of Ministry of Health, Suzhou, 
      Jiangsu 215006, P.R. China.
FAU - Qi, Jiaqian
AU  - Qi J
AD  - Department of Haematology, The First Affiliated Hospital of Soochow University, 
      Jiangsu Institute of Haematology, Suzhou, Jiangsu 215006, P.R. China.
AD  - Soochow University, Collaborative Innovation Centre of Haematology, Suzhou, 
      Jiangsu 215006, P.R. China.
AD  - Key Laboratory of Thrombosis and Haemostasis of Ministry of Health, Suzhou, 
      Jiangsu 215006, P.R. China.
FAU - Zhao, Shixiang
AU  - Zhao S
AD  - Department of Haematology, The First Affiliated Hospital of Soochow University, 
      Jiangsu Institute of Haematology, Suzhou, Jiangsu 215006, P.R. China.
AD  - Soochow University, Collaborative Innovation Centre of Haematology, Suzhou, 
      Jiangsu 215006, P.R. China.
AD  - Key Laboratory of Thrombosis and Haemostasis of Ministry of Health, Suzhou, 
      Jiangsu 215006, P.R. China.
FAU - Shen, Wenhong
AU  - Shen W
AD  - Department of Haematology, The First Affiliated Hospital of Soochow University, 
      Jiangsu Institute of Haematology, Suzhou, Jiangsu 215006, P.R. China.
AD  - Soochow University, Collaborative Innovation Centre of Haematology, Suzhou, 
      Jiangsu 215006, P.R. China.
AD  - Key Laboratory of Thrombosis and Haemostasis of Ministry of Health, Suzhou, 
      Jiangsu 215006, P.R. China.
FAU - Dai, Lan
AU  - Dai L
AD  - Department of Haematology, The First Affiliated Hospital of Soochow University, 
      Jiangsu Institute of Haematology, Suzhou, Jiangsu 215006, P.R. China.
AD  - Soochow University, Collaborative Innovation Centre of Haematology, Suzhou, 
      Jiangsu 215006, P.R. China.
AD  - Key Laboratory of Thrombosis and Haemostasis of Ministry of Health, Suzhou, 
      Jiangsu 215006, P.R. China.
FAU - Han, Wei
AU  - Han W
AD  - Department of Haematology, The First Affiliated Hospital of Soochow University, 
      Jiangsu Institute of Haematology, Suzhou, Jiangsu 215006, P.R. China.
AD  - Soochow University, Collaborative Innovation Centre of Haematology, Suzhou, 
      Jiangsu 215006, P.R. China.
AD  - Key Laboratory of Thrombosis and Haemostasis of Ministry of Health, Suzhou, 
      Jiangsu 215006, P.R. China.
FAU - Huang, Man
AU  - Huang M
AD  - Department of Haematology, The First Affiliated Hospital of Soochow University, 
      Jiangsu Institute of Haematology, Suzhou, Jiangsu 215006, P.R. China.
AD  - Soochow University, Collaborative Innovation Centre of Haematology, Suzhou, 
      Jiangsu 215006, P.R. China.
AD  - Key Laboratory of Thrombosis and Haemostasis of Ministry of Health, Suzhou, 
      Jiangsu 215006, P.R. China.
FAU - Wang, Zhaoyue
AU  - Wang Z
AD  - Department of Haematology, The First Affiliated Hospital of Soochow University, 
      Jiangsu Institute of Haematology, Suzhou, Jiangsu 215006, P.R. China.
AD  - Soochow University, Collaborative Innovation Centre of Haematology, Suzhou, 
      Jiangsu 215006, P.R. China.
AD  - Key Laboratory of Thrombosis and Haemostasis of Ministry of Health, Suzhou, 
      Jiangsu 215006, P.R. China.
FAU - Ruan, Changgeng
AU  - Ruan C
AD  - Department of Haematology, The First Affiliated Hospital of Soochow University, 
      Jiangsu Institute of Haematology, Suzhou, Jiangsu 215006, P.R. China.
AD  - Soochow University, Collaborative Innovation Centre of Haematology, Suzhou, 
      Jiangsu 215006, P.R. China.
AD  - Key Laboratory of Thrombosis and Haemostasis of Ministry of Health, Suzhou, 
      Jiangsu 215006, P.R. China.
FAU - Wu, Depei
AU  - Wu D
AD  - Department of Haematology, The First Affiliated Hospital of Soochow University, 
      Jiangsu Institute of Haematology, Suzhou, Jiangsu 215006, P.R. China.
AD  - Soochow University, Collaborative Innovation Centre of Haematology, Suzhou, 
      Jiangsu 215006, P.R. China.
AD  - Key Laboratory of Thrombosis and Haemostasis of Ministry of Health, Suzhou, 
      Jiangsu 215006, P.R. China.
FAU - Han, Yue
AU  - Han Y
AD  - Department of Haematology, The First Affiliated Hospital of Soochow University, 
      Jiangsu Institute of Haematology, Suzhou, Jiangsu 215006, P.R. China.
AD  - Soochow University, Collaborative Innovation Centre of Haematology, Suzhou, 
      Jiangsu 215006, P.R. China.
AD  - Key Laboratory of Thrombosis and Haemostasis of Ministry of Health, Suzhou, 
      Jiangsu 215006, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170622
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5530094
OTO - NOTNLM
OT  - JAK2V617F mutation
OT  - microparticles
OT  - myeloproliferative neoplasms
OT  - splenomegaly
OT  - thrombosis
EDAT- 2017/08/10 06:00
MHDA- 2017/08/10 06:01
PMCR- 2017/06/22
CRDT- 2017/08/10 06:00
PHST- 2015/11/07 00:00 [received]
PHST- 2017/04/21 00:00 [accepted]
PHST- 2017/08/10 06:00 [entrez]
PHST- 2017/08/10 06:00 [pubmed]
PHST- 2017/08/10 06:01 [medline]
PHST- 2017/06/22 00:00 [pmc-release]
AID - OL-0-0-6459 [pii]
AID - 10.3892/ol.2017.6459 [doi]
PST - ppublish
SO  - Oncol Lett. 2017 Aug;14(2):2531-2536. doi: 10.3892/ol.2017.6459. Epub 2017 Jun 
      22.