PMID- 28791402
OWN - NLM
STAT- MEDLINE
DCOM- 20180514
LR  - 20211204
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 16
IP  - 4
DP  - 2017 Oct
TI  - Role of the ACE2‑Ang‑(1‑7)‑Mas axis in blood pressure regulation and its 
      potential as an antihypertensive in functional foods (Review).
PG  - 4403-4412
LID - 10.3892/mmr.2017.7168 [doi]
AB  - The renin‑angiotensin system (RAS) serves a critical role in blood pressure 
      regulation and prevention of cardiovascular diseases. Efforts to develop 
      functional foods that enhance the RAS have focused on inhibition of 
      angiotensin‑converting enzyme (ACE) activity in the ACE‑angiotensin II (Ang 
      II)‑Ang II type 1 receptor axis. ACE2 and the Mas receptor are important 
      components of this axis. ACE2 catalyzes Ang II into Ang‑(1‑7), which then binds 
      to the G‑protein‑coupled receptor Mas. In addition, it induces nitric oxide 
      release from endothelial cells and exerts antiproliferative, vasodilatory and 
      antihypertensive effects. The present review examined recent findings regarding 
      the physiological and biological roles of the ACE2‑Ang‑(1‑7)‑Mas axis in the 
      cardiovascular system, discussed potential food‑derived ACE2‑activating agents, 
      and highlighted initiatives, based on this axis, that aim to develop functional 
      foods for the treatment of hypertension.
FAU - Lin, Shiqi
AU  - Lin S
AD  - Beijing Key Laboratory of Forest Food Process and Safety, Department of Food 
      Science and Engineering, College of Biological Sciences and Technology, Beijing 
      Forestry University, Beijing 100083, P.R. China.
FAU - Pan, Huanglei
AU  - Pan H
AD  - Beijing Key Laboratory of Forest Food Process and Safety, Department of Food 
      Science and Engineering, College of Biological Sciences and Technology, Beijing 
      Forestry University, Beijing 100083, P.R. China.
FAU - Wu, Hongli
AU  - Wu H
AD  - Beijing Key Laboratory of Forest Food Process and Safety, Department of Food 
      Science and Engineering, College of Biological Sciences and Technology, Beijing 
      Forestry University, Beijing 100083, P.R. China.
FAU - Ren, Difeng
AU  - Ren D
AD  - Beijing Key Laboratory of Forest Food Process and Safety, Department of Food 
      Science and Engineering, College of Biological Sciences and Technology, Beijing 
      Forestry University, Beijing 100083, P.R. China.
FAU - Lu, Jun
AU  - Lu J
AD  - Beijing Engineering Research Center of Protein and Functional Peptides, China 
      National Research Institute of Food and Fermentation Industries, Beijing 100015, 
      P.R. China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170804
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Peptide Fragments)
RN  - 0 (Proto-Oncogene Mas)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 9041-90-1 (Angiotensin I)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
RN  - IJ3FUK8MOF (angiotensin I (1-7))
SB  - IM
MH  - Angiotensin I/*metabolism
MH  - Animals
MH  - Antihypertensive Agents/pharmacology/*therapeutic use
MH  - *Blood Pressure/drug effects
MH  - *Functional Food
MH  - Humans
MH  - Peptide Fragments/*metabolism
MH  - Peptidyl-Dipeptidase A/*metabolism
MH  - Proto-Oncogene Mas
MH  - Proto-Oncogene Proteins/*metabolism
MH  - Receptors, G-Protein-Coupled/*metabolism
EDAT- 2017/08/10 06:00
MHDA- 2018/05/15 06:00
CRDT- 2017/08/10 06:00
PHST- 2016/06/28 00:00 [received]
PHST- 2017/06/08 00:00 [accepted]
PHST- 2017/08/10 06:00 [pubmed]
PHST- 2018/05/15 06:00 [medline]
PHST- 2017/08/10 06:00 [entrez]
AID - 10.3892/mmr.2017.7168 [doi]
PST - ppublish
SO  - Mol Med Rep. 2017 Oct;16(4):4403-4412. doi: 10.3892/mmr.2017.7168. Epub 2017 Aug 
      4.