PMID- 28792113
OWN - NLM
STAT- MEDLINE
DCOM- 20190724
LR  - 20210517
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Linking)
VI  - 13
IP  - 2
DP  - 2019 Apr
TI  - The role of a family history of psychosis for youth at clinical high risk of 
      psychosis.
PG  - 251-256
LID - 10.1111/eip.12471 [doi]
AB  - AIM: On average, there is a 10% to 12% likelihood of developing a psychotic 
      disorder solely based on being at familial high risk. However, the introduction 
      of the criteria for clinical high risk (CHR) of psychosis suggested for CHR 
      individuals, 20% to 30% will go on to develop a full-blown psychotic illness 
      within 3 years. Several studies suggest a role for family history in conversion 
      to psychosis among those at CHR. However, we know very little about those who 
      meet the CHR criteria and have a positive family history for psychosis compared 
      to those at CHR with no known family history. The aim of this study was to 
      compare these 2 groups on demographics, clinical symptoms, social and role 
      functioning, IQ, environmental factors and conversion to psychosis. METHOD: A 
      total of 762 participants met criteria for being at CHR, 119 of whom had a family 
      history (CHR + FH) and 643 without (CHR-FH). Groups were compared on attenuated 
      symptoms, role and social functioning, IQ, past trauma, perceived discrimination 
      and cannabis use. Survival analysis was used to compare groups on conversion 
      rates. RESULTS: There were no major differences between the groups in symptoms, 
      functioning, IQ, cannabis use or in the rate of conversion between the groups. 
      The CHR + FH group reported increased amounts of early trauma. CONCLUSION: There 
      is a possibility that CHR + FH individuals believe that it is more difficult for 
      them to cope with circumstances such as abuse or potential abuse. Future research 
      on this subject should investigate family environment and its role in conversion 
      to psychosis among CHR + FH individuals.
CI  - (c) 2017 John Wiley & Sons Australia, Ltd.
FAU - Georgopoulos, Grace
AU  - Georgopoulos G
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Calgary, Alberta, Canada.
FAU - Stowkowy, Jacqueline
AU  - Stowkowy J
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Calgary, Alberta, Canada.
FAU - Liu, Lu
AU  - Liu L
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Calgary, Alberta, Canada.
FAU - Cadenhead, Kristin S
AU  - Cadenhead KS
AD  - Department of Psychiatry, University of California San Diego, La Jolla, 
      California.
FAU - Cannon, Tyrone D
AU  - Cannon TD
AD  - Department of Psychology, Yale University, New Haven, Connecticut.
FAU - Cornblatt, Barbara A
AU  - Cornblatt BA
AD  - Department of Psychiatry, Zucker Hillside Hospital, Queens, New York.
FAU - McGlashan, Thomas H
AU  - McGlashan TH
AD  - Department of Psychiatry, Yale University, New Haven, Connecticut.
FAU - Perkins, Diana O
AU  - Perkins DO
AD  - Department of Psychiatry, University of North Carolina, Chapel Hill, North 
      Carolina.
FAU - Seidman, Larry J
AU  - Seidman LJ
AD  - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical 
      Center and Massachusetts General Hospital, Boston, Massachusetts.
FAU - Tsuang, Ming T
AU  - Tsuang MT
AD  - Department of Psychiatry, University of California San Diego, La Jolla, 
      California.
AD  - Institute of Genomic Medicine, University of California, La Jolla, California.
FAU - Walker, Elaine F
AU  - Walker EF
AD  - Department of Psychology, Emory University, Atlanta, Georgia.
FAU - Woods, Scott W
AU  - Woods SW
AD  - Department of Psychiatry, Yale University, New Haven, Connecticut.
FAU - Bearden, Carrie E
AU  - Bearden CE
AD  - Department of Psychiatry and Biobehavioral Sciences and Psychology, University of 
      California, Los Angeles, Los Angeles, California.
FAU - Mathalon, Daniel H
AU  - Mathalon DH
AD  - Department of Psychiatry, University of California, San Francisco, San Francisco, 
      California.
AD  - Psychiatry Service, San Francisco, California.
FAU - Addington, Jean
AU  - Addington J
AD  - Hotchkiss Brain Institute, Department of Psychiatry, University of Calgary, 
      Calgary, Alberta, Canada.
LA  - eng
GR  - U01MH08185705/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20170809
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
MH  - Adolescent
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Humans
MH  - Likelihood Functions
MH  - Longitudinal Studies
MH  - Male
MH  - North America
MH  - Prodromal Symptoms
MH  - Psychotic Disorders/diagnosis/*genetics/psychology
MH  - Risk Assessment
MH  - Social Adjustment
MH  - Substance-Related Disorders
MH  - Surveys and Questionnaires
MH  - Survival Analysis
MH  - Young Adult
OTO - NOTNLM
OT  - *family risk
OT  - *prodromal
OT  - *psychosis
EDAT- 2017/08/10 06:00
MHDA- 2019/07/25 06:00
CRDT- 2017/08/10 06:00
PHST- 2016/08/08 00:00 [received]
PHST- 2017/05/01 00:00 [revised]
PHST- 2017/06/17 00:00 [accepted]
PHST- 2017/08/10 06:00 [pubmed]
PHST- 2019/07/25 06:00 [medline]
PHST- 2017/08/10 06:00 [entrez]
AID - 10.1111/eip.12471 [doi]
PST - ppublish
SO  - Early Interv Psychiatry. 2019 Apr;13(2):251-256. doi: 10.1111/eip.12471. Epub 
      2017 Aug 9.