PMID- 28792471
OWN - NLM
STAT- MEDLINE
DCOM- 20180423
LR  - 20190115
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 18
IP  - 8
DP  - 2017 Aug 9
TI  - Comparative Studies on Behavioral, Cognitive and Biomolecular Profiling of ICR, 
      C57BL/6 and Its Sub-Strains Suitable for Scopolamine-Induced Amnesic Models.
LID - 10.3390/ijms18081735 [doi]
LID - 1735
AB  - Cognitive impairment and behavioral disparities are the distinctive baseline 
      features to investigate in most animal models of neurodegenerative disease. 
      However, neuronal complications are multifactorial and demand a suitable animal 
      model to investigate their underlying basal mechanisms. By contrast, the numerous 
      existing neurodegenerative studies have utilized various animal strains, leading 
      to factual disparity. Choosing an optimal mouse strain for preliminary assessment 
      of neuronal complications is therefore imperative. In this study, we 
      systematically compared the behavioral, cognitive, cholinergic, and inflammatory 
      impairments of outbred ICR and inbred C57BL/6 mice strains subject to 
      scopolamine-induced amnesia. We then extended this study to the sub-strains 
      C57BL/6N and C57BL/6J, where in addition to the above-mentioned parameters, their 
      endogenous antioxidant levels and cAMP response-element binding protein 
      (CREB)/brain-derived neurotrophic factor (BDNF) protein expression were also 
      evaluated. Compared with the ICR strain, the scopolamine-inflicted C57BL/6 
      strains exhibited a substantial reduction of spontaneous alternation and an 
      approximately two-fold increase in inflammatory protein expression, compared to 
      the control group. Among the sub-strains, scopolamine-treated C57BL/6N strains 
      exhibited declined step-through latency, elevated acetylcholinesterase (AChE) 
      activity and inflammatory protein expression, associated with reduced endogenous 
      antioxidant levels and p-CREB/BDNF expression, compared to the control and 
      tacrine-treated groups. This indicates that the C57BL/6N strains exhibit 
      significantly enhanced scopolamine-induced neuronal impairment compared to the 
      other evaluated strains.
FAU - Karthivashan, Govindarajan
AU  - Karthivashan G
AD  - Department of Biotechnology, College of Biomedical and Health Science, Konkuk 
      University, Chungju 27478, Korea. karthivashan@gmail.com.
FAU - Park, Shin-Young
AU  - Park SY
AD  - Department of Biotechnology, College of Biomedical and Health Science, Konkuk 
      University, Chungju 27478, Korea. ifresha@nate.com.
FAU - Kim, Joon-Soo
AU  - Kim JS
AD  - Department of Biotechnology, College of Biomedical and Health Science, Konkuk 
      University, Chungju 27478, Korea. kgfdkr@gmail.com.
FAU - Cho, Duk-Yeon
AU  - Cho DY
AD  - Department of Biotechnology, College of Biomedical and Health Science, Konkuk 
      University, Chungju 27478, Korea. ejrdus1026@naver.com.
FAU - Ganesan, Palanivel
AU  - Ganesan P
AD  - Department of Biotechnology, College of Biomedical and Health Science, Konkuk 
      University, Chungju 27478, Korea. palanivel67@gmail.com.
AD  - Nanotechnology Research Center, Department of Applied Life Science, College of 
      Biomedical and Health Science, Konkuk University, Chungju 27478, Korea. 
      palanivel67@gmail.com.
FAU - Choi, Dong-Kug
AU  - Choi DK
AD  - Department of Biotechnology, College of Biomedical and Health Science, Konkuk 
      University, Chungju 27478, Korea. choidk@kku.ac.kr.
AD  - Nanotechnology Research Center, Department of Applied Life Science, College of 
      Biomedical and Health Science, Konkuk University, Chungju 27478, Korea. 
      choidk@kku.ac.kr.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170809
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Adjuvants, Anesthesia)
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - DL48G20X8X (Scopolamine)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
SB  - IM
MH  - Acetylcholinesterase/metabolism
MH  - Adjuvants, Anesthesia/*adverse effects
MH  - Amnesia/*etiology/*metabolism/*psychology
MH  - Animals
MH  - Antioxidants/metabolism
MH  - *Behavior, Animal
MH  - *Biomarkers
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cerebral Cortex/metabolism
MH  - *Cognitive Dysfunction
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Enzyme Activation
MH  - Gene Expression
MH  - Hippocampus/metabolism
MH  - Inflammation/genetics/metabolism
MH  - Lipid Peroxidation
MH  - Male
MH  - Memory Disorders/etiology/psychology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred ICR
MH  - Scopolamine/*adverse effects
MH  - Spatial Learning
MH  - Species Specificity
PMC - PMC5578125
OTO - NOTNLM
OT  - C57BL/6J sub-strains
OT  - C57BL/6N
OT  - CREB/BDNF
OT  - amnesia
OT  - cognition
OT  - inbred C57BL/6 strains
OT  - outbred ICR strains
OT  - scopolamine
COIS- The authors declare no conflict of interest.
EDAT- 2017/08/10 06:00
MHDA- 2018/04/24 06:00
PMCR- 2017/08/01
CRDT- 2017/08/10 06:00
PHST- 2017/07/05 00:00 [received]
PHST- 2017/07/31 00:00 [revised]
PHST- 2017/08/01 00:00 [accepted]
PHST- 2017/08/10 06:00 [entrez]
PHST- 2017/08/10 06:00 [pubmed]
PHST- 2018/04/24 06:00 [medline]
PHST- 2017/08/01 00:00 [pmc-release]
AID - ijms18081735 [pii]
AID - ijms-18-01735 [pii]
AID - 10.3390/ijms18081735 [doi]
PST - epublish
SO  - Int J Mol Sci. 2017 Aug 9;18(8):1735. doi: 10.3390/ijms18081735.