PMID- 2879607
OWN - NLM
STAT- MEDLINE
DCOM- 19870310
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 398
IP  - 1
DP  - 1986 Nov 19
TI  - Release of met-enkephalin from rat striatal slices: effect of amphetamine and 
      fipexide.
PG  - 212-4
AB  - The release of Met-enkephalin immunoreactive material (ME-IR) from rat striatal 
      slices is affected by exposure to amphetamine and fipexide 
      (chloro-4-phenoxy)-2-acetyl-1-(methylene-dioxy 3, 4-benzyl-4-piperazine) a 
      psychostimulant drug with mild dopaminomimetic activity. Both amphetamine and 
      fipexide inhibited in vitro the release of ME-IR. The same effect was observed 
      after in vivo acute administration and is also maintained after chronic 
      treatment. The action of fipexide and amphetamine is still present after 
      reserpine pretreatment. The results indicate that fipexide may facilitate 
      dopamine neurotransmission by inhibition of an enkephalinergic inhibitory 
      feed-back circuit.
FAU - Lucchi, L
AU  - Lucchi L
FAU - Govoni, S
AU  - Govoni S
FAU - Spano, P F
AU  - Spano PF
FAU - Trabucchi, M
AU  - Trabucchi M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Amphetamines)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Piperazines)
RN  - 58569-55-4 (Enkephalin, Methionine)
RN  - RWP5GA015D (Potassium)
RN  - TG44VME01D (fipexide)
SB  - IM
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Caudate Nucleus/drug effects/*metabolism
MH  - Central Nervous System Stimulants/pharmacology
MH  - Enkephalin, Methionine/*metabolism
MH  - Male
MH  - Piperazines/*pharmacology
MH  - Potassium/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1986/11/19 00:00
MHDA- 1986/11/19 00:01
CRDT- 1986/11/19 00:00
PHST- 1986/11/19 00:00 [pubmed]
PHST- 1986/11/19 00:01 [medline]
PHST- 1986/11/19 00:00 [entrez]
AID - 0006-8993(86)91273-4 [pii]
AID - 10.1016/0006-8993(86)91273-4 [doi]
PST - ppublish
SO  - Brain Res. 1986 Nov 19;398(1):212-4. doi: 10.1016/0006-8993(86)91273-4.