PMID- 28797597
OWN - NLM
STAT- MEDLINE
DCOM- 20180522
LR  - 20180522
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 335
DP  - 2017 Sep 29
TI  - Environmental enrichment protects spatial learning and hippocampal neurons from 
      the long-lasting effects of protein malnutrition early in life.
PG  - 55-62
LID - S0166-4328(17)30933-6 [pii]
LID - 10.1016/j.bbr.2017.08.012 [doi]
AB  - As early protein malnutrition has a critically long-lasting impact on the 
      hippocampal formation and its role in learning and memory, and environmental 
      enrichment has demonstrated great success in ameliorating functional deficits, 
      here we ask whether exposure to an enriched environment could be employed to 
      prevent spatial memory impairment and neuroanatomical changes in the hippocampus 
      of adult rats maintained on a protein deficient diet during brain development 
      (P0-P35). To elucidate the protective effects of environmental enrichment, we 
      used the Morris water task and neuroanatomical analysis to determine whether 
      changes in spatial memory and number and size of CA1 neurons differed 
      significantly among groups. Protein malnutrition and environmental enrichment 
      during brain development had significant effects on the spatial memory and 
      hippocampal anatomy of adult rats. Malnourished but non-enriched rats (MN) 
      required more time to find the hidden platform than well-nourished but 
      non-enriched rats (WN). Malnourished but enriched rats (ME) performed better than 
      the MN and similarly to the WN rats. There was no difference between 
      well-nourished but non-enriched and enriched rats (WE). Anatomically, fewer CA1 
      neurons were found in the hippocampus of MN rats than in those of WN rats. 
      However, it was also observed that ME and WN rats retained a similar number of 
      neurons. These results suggest that environmental enrichment during brain 
      development alters cognitive task performance and hippocampal neuroanatomy in a 
      manner that is neuroprotective against malnutrition-induced brain injury. These 
      results could have significant implications for malnourished infants expected to 
      be at risk of disturbed brain development.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Soares, Roberto O
AU  - Soares RO
AD  - Laboratory of Neuroanatomy, Department of Surgery and Anatomy, Ribeirao Preto 
      Medical School, University of Sao Paulo, Sao Paulo, Brazil.
FAU - Horiquini-Barbosa, Everton
AU  - Horiquini-Barbosa E
AD  - Laboratory of Neuroanatomy, Department of Surgery and Anatomy, Ribeirao Preto 
      Medical School, University of Sao Paulo, Sao Paulo, Brazil.
FAU - Almeida, Sebastiao S
AU  - Almeida SS
AD  - Laboratory of Nutrition & Behavior, Department of Psychology, Faculty of 
      Philosophy Sciences and Letters of Ribeirao Preto, University of Sao Paulo, Sao 
      Paulo, Brazil.
FAU - Lachat, Joao-Jose
AU  - Lachat JJ
AD  - Laboratory of Neuroanatomy, Department of Surgery and Anatomy, Ribeirao Preto 
      Medical School, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: 
      jjlachat@fmrp.usp.br.
LA  - eng
PT  - Journal Article
DEP - 20170808
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
SB  - IM
MH  - Animals
MH  - Brain/growth & development/physiopathology
MH  - Environment
MH  - Hippocampus/growth & development/metabolism
MH  - Male
MH  - Malnutrition/*metabolism
MH  - Maze Learning/drug effects
MH  - Memory Disorders/physiopathology
MH  - Neurons
MH  - Rats
MH  - Rats, Wistar
MH  - Spatial Learning/physiology
MH  - Spatial Memory/*physiology
MH  - Temporal Lobe/physiopathology
OTO - NOTNLM
OT  - Environmental enrichment
OT  - Hippocampus
OT  - Learning
OT  - Memory
OT  - Morris water maze
OT  - Protein malnutrition
EDAT- 2017/08/12 06:00
MHDA- 2018/05/23 06:00
CRDT- 2017/08/12 06:00
PHST- 2017/06/01 00:00 [received]
PHST- 2017/07/25 00:00 [revised]
PHST- 2017/08/05 00:00 [accepted]
PHST- 2017/08/12 06:00 [pubmed]
PHST- 2018/05/23 06:00 [medline]
PHST- 2017/08/12 06:00 [entrez]
AID - S0166-4328(17)30933-6 [pii]
AID - 10.1016/j.bbr.2017.08.012 [doi]
PST - ppublish
SO  - Behav Brain Res. 2017 Sep 29;335:55-62. doi: 10.1016/j.bbr.2017.08.012. Epub 2017 
      Aug 8.