PMID- 28797603
OWN - NLM
STAT- MEDLINE
DCOM- 20180522
LR  - 20180522
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 335
DP  - 2017 Sep 29
TI  - Chronic traumatic stress impairs memory in mice: Potential roles of 
      acetylcholine, neuroinflammation and corticotropin releasing factor expression in 
      the hippocampus.
PG  - 32-40
LID - S0166-4328(17)30969-5 [pii]
LID - 10.1016/j.bbr.2017.08.013 [doi]
AB  - Chronic stress in humans can result in multiple adverse psychiatric and 
      neurobiological outcomes, including memory deficits. These adverse outcomes can 
      be more severe if each episode of stress is very traumatic. When compared to 
      acute or short term stress relatively little is known about the effects of 
      chronic traumatic stress on memory and molecular changes in hippocampus, a brain 
      area involved in memory processing. Here we studied the effects of chronic 
      traumatic stress in mice by exposing them to adult Long Evan rats for 28 
      consecutive days and subsequently analyzing behavioral outcomes and the changes 
      in the hippocampus. Results show that stressed mice developed memory deficits 
      when assayed with radial arm maze tasks. However, chronic traumatic stress did 
      not induce anxiety, locomotor hyperactivity or anhedonia. In the hippocampus of 
      stressed mice interleukin-1beta protein expression was increased along with 
      decreased corticotropin releasing hormone (CRH) gene expression. Furthermore, 
      there was a reduction in acetylcholine levels in the hippocampus of stressed 
      mice. There were no changes in brain derived neurotrophic factor (BDNF) or nerve 
      growth factor (NGF) levels in the hippocampus of stressed mice. Gene expression 
      of immediate early genes (Zif268, Arc, C-Fos) as well as glucocorticoid and 
      mineralocorticoid receptors were also not affected by chronic stress. These data 
      demonstrate that chronic traumatic stress followed by a recovery period might 
      lead to development of resilience resulting in the development of selected, most 
      vulnerable behavioral alterations and molecular changes in the hippocampus.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Bhakta, Ami
AU  - Bhakta A
AD  - Department of Biological and Environmental Science, Texas A&M 
      University-Commerce, Commerce, TX 75428, United States.
FAU - Gavini, Kartheek
AU  - Gavini K
AD  - Department of Biological and Environmental Science, Texas A&M 
      University-Commerce, Commerce, TX 75428, United States.
FAU - Yang, Euitaek
AU  - Yang E
AD  - Department of Biological and Environmental Science, Texas A&M 
      University-Commerce, Commerce, TX 75428, United States.
FAU - Lyman-Henley, Lani
AU  - Lyman-Henley L
AD  - Department of Biological and Environmental Science, Texas A&M 
      University-Commerce, Commerce, TX 75428, United States.
FAU - Parameshwaran, Kodeeswaran
AU  - Parameshwaran K
AD  - Department of Biological and Environmental Science, Texas A&M 
      University-Commerce, Commerce, TX 75428, United States. Electronic address: 
      kparameshwaran@tamuc.edu.
LA  - eng
PT  - Journal Article
DEP - 20170808
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Receptors, Corticotropin-Releasing Hormone)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/metabolism
MH  - Animals
MH  - Anxiety
MH  - Corticotropin-Releasing Hormone/*metabolism
MH  - Gene Expression Regulation
MH  - Hippocampus/metabolism
MH  - Learning/physiology
MH  - Male
MH  - Memory/*physiology
MH  - Memory Disorders/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neurogenic Inflammation/metabolism
MH  - Rats
MH  - Rats, Long-Evans
MH  - Receptors, Corticotropin-Releasing Hormone/metabolism
MH  - Stress, Psychological/*metabolism
OTO - NOTNLM
OT  - CRH
OT  - Chronic
OT  - Hippocampus
OT  - Inflammation
OT  - Memory
OT  - Stress
EDAT- 2017/08/12 06:00
MHDA- 2018/05/23 06:00
CRDT- 2017/08/12 06:00
PHST- 2017/06/08 00:00 [received]
PHST- 2017/07/24 00:00 [revised]
PHST- 2017/08/05 00:00 [accepted]
PHST- 2017/08/12 06:00 [pubmed]
PHST- 2018/05/23 06:00 [medline]
PHST- 2017/08/12 06:00 [entrez]
AID - S0166-4328(17)30969-5 [pii]
AID - 10.1016/j.bbr.2017.08.013 [doi]
PST - ppublish
SO  - Behav Brain Res. 2017 Sep 29;335:32-40. doi: 10.1016/j.bbr.2017.08.013. Epub 2017 
      Aug 8.