PMID- 28797764
OWN - NLM
STAT- MEDLINE
DCOM- 20180524
LR  - 20180524
IS  - 1873-488X (Electronic)
IS  - 1056-8719 (Linking)
VI  - 88
IP  - Pt 1
DP  - 2017 Nov
TI  - Inflammatory pain assessment in the arthritis of the temporomandibular joint in 
      rats: A comparison between two phlogistic agents.
PG  - 100-108
LID - S1056-8719(17)30039-4 [pii]
LID - 10.1016/j.vascn.2017.08.001 [doi]
AB  - Temporomandibular joint (TMJ) disorders are a group of conditions that result in 
      TMJ pain, which frequently limits basic daily activities. Experimental models 
      that allow the study of the mechanisms underlying these inflammatory and pain 
      conditions are of great clinical relevance. The aim of this study was to evaluate 
      nociception, inflammation and participation of the macrophage/microglia cells in 
      the arthritis of the TMJ induced by two phlogistic agents. 84 rats were divided 
      into 2 groups: Zy, which received zymosan intra-articularly, or Cg, which 
      received carrageenan intra-articularly. Mechanical nociception, total leukocyte 
      influx to the synovial fluid and histopathological analyses were evaluated in the 
      TMJ. The participation of macrophage/microglia located in trigeminal ganglia (TG) 
      and in the subnucleus caudalis (V-SnC) was assessed immunohistochemically. Both 
      agents induced mechanical hyperalgesia 6h after the induction, but a more 
      persistent algesic state was perceived in the Cg group, which lasted for 120h. 
      Even though both groups presented increased leukocyte influx, the Zy-group 
      presented a more intense influx. Zymosan recruited resident macrophage in the 
      trigeminal ganglia 24h after the injection. In the V-SnC, the group Cg presented 
      a more prolonged immunolabeling pattern in comparison with the group Zy. It can 
      be concluded that zymosan induced a more intense infiltrate and peripheral 
      nervous changes, while Cg lead to a moderate TMJ inflammation with prominent 
      changes in the V-SnC.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - de Araujo, Joana Claudia Bezerra
AU  - de Araujo JCB
AD  - Pharmacology Post Graduation Program, Department of Physiology and Pharmacology, 
      Federal University of Ceara, Brazil.
FAU - Gondim, Delane Viana
AU  - Gondim DV
AD  - Morphofunctional Sciences Post Graduation Program, Department of Morphology, 
      Federal University of Ceara, Brazil.
FAU - Cavalcante, Andre Luiz Cunha
AU  - Cavalcante ALC
AD  - Medical Sciences Post Graduation Program, Department of Clinical Medicine, 
      Federal University of Ceara, Brazil.
FAU - Lisboa, Mario Roberto Pontes
AU  - Lisboa MRP
AD  - Morphofunctional Sciences Post Graduation Program, Department of Morphology, 
      Federal University of Ceara, Brazil.
FAU - de Castro Brito, Gerly Anne
AU  - de Castro Brito GA
AD  - Morphofunctional Sciences Post Graduation Program, Department of Morphology, 
      Federal University of Ceara, Brazil.
FAU - Vale, Mariana Lima
AU  - Vale ML
AD  - Pharmacology Post Graduation Program, Department of Physiology and Pharmacology, 
      Federal University of Ceara, Brazil; Morphofunctional Sciences Post Graduation 
      Program, Department of Morphology, Federal University of Ceara, Brazil. 
      Electronic address: mariana.vale@pq.cnpq.br.
LA  - eng
PT  - Journal Article
DEP - 20170808
PL  - United States
TA  - J Pharmacol Toxicol Methods
JT  - Journal of pharmacological and toxicological methods
JID - 9206091
RN  - 9000-07-1 (Carrageenan)
RN  - 9010-72-4 (Zymosan)
SB  - IM
MH  - Animals
MH  - Arthritis/chemically induced/diagnosis/pathology/*physiopathology
MH  - Carrageenan/pharmacology
MH  - Disease Models, Animal
MH  - Hyperalgesia/chemically induced/pathology/*physiopathology
MH  - Injections, Intra-Articular
MH  - Macrophages/drug effects/pathology
MH  - Male
MH  - Microglia/drug effects/pathology
MH  - Nociception/drug effects/physiology
MH  - Pain/chemically induced/pathology/*physiopathology
MH  - Pain Measurement/*methods
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Rats, Wistar
MH  - Temporomandibular Joint Disorders/chemically induced/pathology/*physiopathology
MH  - Trigeminal Ganglion/cytology/drug effects
MH  - Zymosan/pharmacology
EDAT- 2017/08/12 06:00
MHDA- 2018/05/25 06:00
CRDT- 2017/08/12 06:00
PHST- 2017/02/25 00:00 [received]
PHST- 2017/07/21 00:00 [revised]
PHST- 2017/08/05 00:00 [accepted]
PHST- 2017/08/12 06:00 [pubmed]
PHST- 2018/05/25 06:00 [medline]
PHST- 2017/08/12 06:00 [entrez]
AID - S1056-8719(17)30039-4 [pii]
AID - 10.1016/j.vascn.2017.08.001 [doi]
PST - ppublish
SO  - J Pharmacol Toxicol Methods. 2017 Nov;88(Pt 1):100-108. doi: 
      10.1016/j.vascn.2017.08.001. Epub 2017 Aug 8.