PMID- 28797847
OWN - NLM
STAT- MEDLINE
DCOM- 20180524
LR  - 20181113
IS  - 1873-6513 (Electronic)
IS  - 0885-3924 (Print)
IS  - 0885-3924 (Linking)
VI  - 54
IP  - 3
DP  - 2017 Sep
TI  - Cytokine Gene Polymorphisms Associated With Symptom Clusters in Oncology Patients 
      Undergoing Radiation Therapy.
PG  - 305-316.e3
LID - S0885-3924(17)30355-X [pii]
LID - 10.1016/j.jpainsymman.2017.05.007 [doi]
AB  - CONTEXT: Most of the reviews on the biological basis for symptom clusters suggest 
      that inflammatory processes are involved in the development and maintenance of 
      the symptom clusters. However, no studies have evaluated for associations between 
      genetic polymorphisms and common symptom clusters (e.g., mood disturbance, 
      sickness behavior). OBJECTIVES: Examine the associations between cytokine gene 
      polymorphisms and the severity of three distinct symptom clusters (i.e., 
      mood-cognitive, sickness-behavior, treatment-related) in a sample of patients 
      with breast and prostate cancer (n = 157) at the completion of radiation therapy. 
      METHODS: Symptom severity was assessed using the Memorial Symptom Assessment 
      Scale. Symptom clusters were created using exploratory factor analysis. The 
      associations between cytokine gene polymorphisms and the symptom cluster severity 
      scores were evaluated using regression analyses. RESULTS: Polymorphisms in C-X-C 
      motif chemokine ligand 8 (CXCL8), interleukin (IL13), and nuclear factor kappa 
      beta 2 (NFKB2) were associated with severity scores for the mood-cognitive 
      symptom cluster. In addition to interferon gamma (IFNG1), the same polymorphism 
      in NFKB2 (i.e., rs1056890) that was associated with the mood-cognitive symptom 
      cluster score was associated with the sickness-behavior symptom cluster. 
      Polymorphisms in interleukin 1 receptor 1 (IL1R1), IL6, and NFKB1 were associated 
      with severity factor scores for the treatment-related symptom cluster. 
      CONCLUSION: Our findings support the hypotheses that symptoms that cluster 
      together have a common underlying mechanism and the most common symptom clusters 
      in oncology patients are associated polymorphisms in genes involved in a variety 
      of inflammatory processes.
CI  - Copyright (c) 2017 American Academy of Hospice and Palliative Medicine. Published 
      by Elsevier Inc. All rights reserved.
FAU - Miaskowski, Christine
AU  - Miaskowski C
AD  - School of Nursing, University of California, San Francisco, California, USA. 
      Electronic address: chris.miaskowski@ucsf.edu.
FAU - Conley, Yvette P
AU  - Conley YP
AD  - School of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
FAU - Mastick, Judy
AU  - Mastick J
AD  - School of Nursing, University of California, San Francisco, California, USA.
FAU - Paul, Steven M
AU  - Paul SM
AD  - School of Nursing, University of California, San Francisco, California, USA.
FAU - Cooper, Bruce A
AU  - Cooper BA
AD  - School of Nursing, University of California, San Francisco, California, USA.
FAU - Levine, Jon D
AU  - Levine JD
AD  - School of Medicine, University of California, San Francisco, California, USA.
FAU - Knisely, Mitchell
AU  - Knisely M
AD  - School of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
FAU - Kober, Kord M
AU  - Kober KM
AD  - School of Nursing, University of California, San Francisco, California, USA.
LA  - eng
GR  - K05 CA168960/CA/NCI NIH HHS/United States
GR  - R01 NR004835/NR/NINR NIH HHS/United States
GR  - T32 NR009759/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20170808
PL  - United States
TA  - J Pain Symptom Manage
JT  - Journal of pain and symptom management
JID - 8605836
RN  - 0 (Cytokines)
SB  - IM
MH  - Breast Neoplasms/*genetics/physiopathology/psychology/*radiotherapy
MH  - Comorbidity
MH  - Cytokines/*genetics
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Genetic Association Studies
MH  - Humans
MH  - Linear Models
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - *Polymorphism, Genetic
MH  - Principal Component Analysis
MH  - Prostatic Neoplasms/*genetics/physiopathology/psychology/*radiotherapy
MH  - Regression Analysis
MH  - Self Report
MH  - Severity of Illness Index
PMC - PMC5610097
MID - NIHMS898254
OTO - NOTNLM
OT  - Symptom clusters
OT  - cytokine genes
OT  - exploratory factor analysis
OT  - radiation therapy
COIS- Conflicts of interest: The authors have no conflicts of interest to declare.
EDAT- 2017/08/12 06:00
MHDA- 2018/05/25 06:00
PMCR- 2018/09/01
CRDT- 2017/08/12 06:00
PHST- 2017/01/31 00:00 [received]
PHST- 2017/04/07 00:00 [revised]
PHST- 2017/05/09 00:00 [accepted]
PHST- 2017/08/12 06:00 [pubmed]
PHST- 2018/05/25 06:00 [medline]
PHST- 2017/08/12 06:00 [entrez]
PHST- 2018/09/01 00:00 [pmc-release]
AID - S0885-3924(17)30355-X [pii]
AID - 10.1016/j.jpainsymman.2017.05.007 [doi]
PST - ppublish
SO  - J Pain Symptom Manage. 2017 Sep;54(3):305-316.e3. doi: 
      10.1016/j.jpainsymman.2017.05.007. Epub 2017 Aug 8.