PMID- 28797929
OWN - NLM
STAT- MEDLINE
DCOM- 20180130
LR  - 20211204
IS  - 1873-4847 (Electronic)
IS  - 0955-2863 (Linking)
VI  - 48
DP  - 2017 Oct
TI  - Antiallergic effect of fisetin on IgE-mediated mast cell activation in vitro and 
      on passive cutaneous anaphylaxis (PCA).
PG  - 103-111
LID - S0955-2863(16)30372-2 [pii]
LID - 10.1016/j.jnutbio.2017.06.010 [doi]
AB  - Fisetin (3,7,3',4'-tetrahydroxyflavone), a naturally occurring bioactive 
      flavonoid, has been shown to inhibit inflammation. However, little is known about 
      the effect of fisetin on immunoglobulin E (IgE)-mediated allergic responses. In 
      this study, the effect of fisetin on rat basophilic leukemia (RBL-2H3) 
      cell-mediated allergic reactions was investigated. Fisetin inhibited 
      beta-hexosaminidase release and decreased the level of interleukin-4 and tumor 
      necrosis factor-alpha mRNA in IgE/antigen (IgE/Ag)-stimulated RBL-2H3 cells. To 
      elucidate the antiallergic mechanism, we examined the levels of signaling 
      molecules responsible for degranulation and release of inflammatory cytokines. 
      Fisetin decreased the levels of activated spleen tyrosine kinase, Gab2 proteins, 
      linker of activated T cells, extracellular signal-related kinase 1/2 in the 
      IgE/Ag-stimulated RBL2H3 cells, and NFkappaB and STAT3 proteins activated in the ear 
      tissue of mice with passive cutaneous anaphylaxis (PCA). In addition, fisetin 
      significantly lowered of FcvarepsilonRI alpha-subunit mRNA expression. Consistent with the 
      cellular data, fisetin markedly suppressed RBL-2H3 cell-dependent PCA in 
      IgE/Ag-sensitized mice. These results suggest that fisetin may have potential as 
      a therapeutic agent for the treatment of allergic diseases.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Jo, Woo-Ri
AU  - Jo WR
AD  - Department of Food Science and Biotechnology, College of BioNano Technology, 
      Gachon University, 1342 Seongnam-daero, Sujeong gu Seongnam-si Gyeonggi-do, 
      461-701, Republic of Korea.
FAU - Park, Hye-Jin
AU  - Park HJ
AD  - Department of Food Science and Biotechnology, College of BioNano Technology, 
      Gachon University, 1342 Seongnam-daero, Sujeong gu Seongnam-si Gyeonggi-do, 
      461-701, Republic of Korea. Electronic address: nimpi79@hanmail.net.
LA  - eng
PT  - Journal Article
DEP - 20170630
PL  - United States
TA  - J Nutr Biochem
JT  - The Journal of nutritional biochemistry
JID - 9010081
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Cytokines)
RN  - 0 (FCER1A protein, rat)
RN  - 0 (Flavonoids)
RN  - 0 (Flavonols)
RN  - 0 (NF-kappa B)
RN  - 0 (Receptors, IgE)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (Stat3 protein, rat)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - OO2ABO9578 (fisetin)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/*pharmacology
MH  - Cell Degranulation/drug effects
MH  - Cell Line, Tumor
MH  - Cytokines/genetics
MH  - Ear/pathology
MH  - Flavonoids/*pharmacology
MH  - Flavonols
MH  - Gene Expression Regulation/drug effects
MH  - Immunoglobulin E/metabolism/pharmacology
MH  - Male
MH  - Mast Cells/*drug effects/physiology
MH  - Mice, Inbred BALB C
MH  - NF-kappa B/metabolism
MH  - Passive Cutaneous Anaphylaxis/*drug effects
MH  - Rats
MH  - Receptors, IgE/genetics
MH  - STAT3 Transcription Factor/metabolism
OTO - NOTNLM
OT  - Basophil
OT  - Cytokines
OT  - Fisetin
OT  - IgE-mediated allergic diseases
OT  - Mast cell
OT  - Passive cutaneous anaphylaxis
OT  - Syk kinase
EDAT- 2017/08/12 06:00
MHDA- 2018/01/31 06:00
CRDT- 2017/08/12 06:00
PHST- 2016/08/12 00:00 [received]
PHST- 2017/06/16 00:00 [revised]
PHST- 2017/06/19 00:00 [accepted]
PHST- 2017/08/12 06:00 [pubmed]
PHST- 2018/01/31 06:00 [medline]
PHST- 2017/08/12 06:00 [entrez]
AID - S0955-2863(16)30372-2 [pii]
AID - 10.1016/j.jnutbio.2017.06.010 [doi]
PST - ppublish
SO  - J Nutr Biochem. 2017 Oct;48:103-111. doi: 10.1016/j.jnutbio.2017.06.010. Epub 
      2017 Jun 30.