PMID- 28798343
OWN - NLM
STAT- MEDLINE
DCOM- 20190304
LR  - 20211204
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Aug 10
TI  - Isoflurane produces antidepressant effects and induces TrkB signaling in rodents.
PG  - 7811
LID - 10.1038/s41598-017-08166-9 [doi]
LID - 7811
AB  - A brief burst-suppressing isoflurane anesthesia has been shown to rapidly 
      alleviate symptoms of depression in a subset of patients, but the neurobiological 
      basis of these observations remains obscure. We show that a single isoflurane 
      anesthesia produces antidepressant-like behavioural effects in the learned 
      helplessness paradigm and regulates molecular events implicated in the mechanism 
      of action of rapid-acting antidepressant ketamine: activation of brain-derived 
      neurotrophic factor (BDNF) receptor TrkB, facilitation of mammalian target of 
      rapamycin (mTOR) signaling pathway and inhibition of glycogen synthase kinase 3beta 
      (GSK3beta). Moreover, isoflurane affected neuronal plasticity by facilitating 
      long-term potentiation in the hippocampus. We also found that isoflurane 
      increased activity of the parvalbumin interneurons, and facilitated GABAergic 
      transmission in wild type mice but not in transgenic mice with reduced TrkB 
      expression in parvalbumin interneurons. Our findings strengthen the role of TrkB 
      signaling in the antidepressant responses and encourage further evaluation of 
      isoflurane as a rapid-acting antidepressant devoid of the psychotomimetic effects 
      and abuse potential of ketamine.
FAU - Antila, Hanna
AU  - Antila H
AD  - Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FI-00014, 
      Finland.
FAU - Ryazantseva, Maria
AU  - Ryazantseva M
AD  - Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FI-00014, 
      Finland.
AD  - Division of Physiology and Neuroscience, Department of Biosciences, Faculty of 
      Biological and Environmental Sciences, University of Helsinki, P.O. Box 66, 
      Helsinki, FI-00014, Finland.
FAU - Popova, Dina
AU  - Popova D
AD  - Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FI-00014, 
      Finland.
FAU - Sipila, Pia
AU  - Sipila P
AD  - Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FI-00014, 
      Finland.
FAU - Guirado, Ramon
AU  - Guirado R
AUID- ORCID: 0000-0003-0259-5709
AD  - Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FI-00014, 
      Finland.
FAU - Kohtala, Samuel
AU  - Kohtala S
AUID- ORCID: 0000-0001-9249-085X
AD  - Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FI-00014, 
      Finland.
AD  - Division of Physiology and Neuroscience, Department of Biosciences, Faculty of 
      Biological and Environmental Sciences, University of Helsinki, P.O. Box 66, 
      Helsinki, FI-00014, Finland.
FAU - Yalcin, Ipek
AU  - Yalcin I
AD  - Institut des Neurosciences Cellulaires et Integratives, Centre National de la 
      Recherche Scientifique, FR-67084, Strasbourg Cedex, France.
FAU - Lindholm, Jesse
AU  - Lindholm J
AD  - Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FI-00014, 
      Finland.
FAU - Vesa, Liisa
AU  - Vesa L
AD  - Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FI-00014, 
      Finland.
FAU - Sato, Vinicius
AU  - Sato V
AD  - School of Pharmaceutical Sciences of Ribeirao Preto, 14040-903, Ribeirao Preto, 
      Sao Paulo, Brazil.
FAU - Cordeira, Joshua
AU  - Cordeira J
AD  - Tufts University, Boston, MA, USA.
FAU - Autio, Henri
AU  - Autio H
AD  - Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FI-00014, 
      Finland.
FAU - Kislin, Mikhail
AU  - Kislin M
AD  - Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FI-00014, 
      Finland.
FAU - Rios, Maribel
AU  - Rios M
AD  - Tufts University, Boston, MA, USA.
FAU - Joca, Samia
AU  - Joca S
AD  - School of Pharmaceutical Sciences of Ribeirao Preto, 14040-903, Ribeirao Preto, 
      Sao Paulo, Brazil.
FAU - Casarotto, Plinio
AU  - Casarotto P
AD  - Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FI-00014, 
      Finland.
FAU - Khiroug, Leonard
AU  - Khiroug L
AD  - Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FI-00014, 
      Finland.
FAU - Lauri, Sari
AU  - Lauri S
AD  - Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FI-00014, 
      Finland.
AD  - Division of Physiology and Neuroscience, Department of Biosciences, Faculty of 
      Biological and Environmental Sciences, University of Helsinki, P.O. Box 66, 
      Helsinki, FI-00014, Finland.
FAU - Taira, Tomi
AU  - Taira T
AD  - Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FI-00014, 
      Finland.
AD  - Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University 
      of Helsinki, P.O. Box 66, FI-00014, Helsinki, Finland.
FAU - Castren, Eero
AU  - Castren E
AUID- ORCID: 0000-0002-1402-2791
AD  - Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FI-00014, 
      Finland. eero.castren@helsinki.fi.
FAU - Rantamaki, Tomi
AU  - Rantamaki T
AUID- ORCID: 0000-0002-0052-1434
AD  - Neuroscience Center, University of Helsinki, P.O. Box 56, Helsinki, FI-00014, 
      Finland. tomi.rantamaki@helsinki.fi.
AD  - Division of Physiology and Neuroscience, Department of Biosciences, Faculty of 
      Biological and Environmental Sciences, University of Helsinki, P.O. Box 66, 
      Helsinki, FI-00014, Finland. tomi.rantamaki@helsinki.fi.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170810
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Antidepressive Agents)
RN  - 0 (Parvalbumins)
RN  - 690G0D6V8H (Ketamine)
RN  - CYS9AKD70P (Isoflurane)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*administration & dosage/pharmacology
MH  - GABAergic Neurons/drug effects/metabolism
MH  - Glycogen Synthase Kinase 3 beta/metabolism
MH  - Helplessness, Learned
MH  - Hippocampus/drug effects/metabolism/*physiology
MH  - Isoflurane/*administration & dosage/pharmacology
MH  - Ketamine/pharmacology
MH  - Long-Term Potentiation
MH  - Male
MH  - Mice
MH  - Parvalbumins/metabolism
MH  - Rats
MH  - Receptor, trkB/*metabolism
MH  - Signal Transduction/drug effects
MH  - TOR Serine-Threonine Kinases/metabolism
PMC - PMC5552878
COIS- L.K. is a paid employee in Neurotar Ltd.
EDAT- 2017/08/12 06:00
MHDA- 2019/03/05 06:00
PMCR- 2017/08/10
CRDT- 2017/08/12 06:00
PHST- 2017/05/15 00:00 [received]
PHST- 2017/07/06 00:00 [accepted]
PHST- 2017/08/12 06:00 [entrez]
PHST- 2017/08/12 06:00 [pubmed]
PHST- 2019/03/05 06:00 [medline]
PHST- 2017/08/10 00:00 [pmc-release]
AID - 10.1038/s41598-017-08166-9 [pii]
AID - 8166 [pii]
AID - 10.1038/s41598-017-08166-9 [doi]
PST - epublish
SO  - Sci Rep. 2017 Aug 10;7(1):7811. doi: 10.1038/s41598-017-08166-9.