PMID- 28798751
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 8
DP  - 2017
TI  - Role of Dendritic Cells in Inflammation and Loss of Tolerance in the Elderly.
PG  - 896
LID - 10.3389/fimmu.2017.00896 [doi]
LID - 896
AB  - Dendritic cells (DCs) play an important role in advancing age-associated 
      progressive decline in adaptive immune responses, loss of tolerance, and 
      development of chronic inflammation. In aged humans, DCs secrete increased levels 
      of pro-inflammatory cytokines and decreased levels of anti-inflammatory and 
      immune-regulatory cytokines. This may contribute to both chronic inflammation and 
      loss of tolerance in aging. Aged DCs also display increased immune response 
      against self-antigens contributing further to both inflammation and loss of 
      tolerance. The secretion of innate protective cytokines such as type I and III 
      interferons is decreased, and the function of DCs in airway remodeling and 
      inflammation in aged is also compromised. Furthermore, the capacity of DCs to 
      prime T cell responses also seems to be affected. Collectively, these changes in 
      DC functions contribute to the immune dysfunction and inflammation in the 
      elderly. This review only focuses on age-associated changes in DC function in 
      humans.
FAU - Agrawal, Anshu
AU  - Agrawal A
AD  - Division of Basic and Clinical Immunology, Department of Medicine, University of 
      California, Irvine, Irvine, CA, United States.
FAU - Agrawal, Sudhanshu
AU  - Agrawal S
AD  - Division of Basic and Clinical Immunology, Department of Medicine, University of 
      California, Irvine, Irvine, CA, United States.
FAU - Gupta, Sudhir
AU  - Gupta S
AD  - Division of Basic and Clinical Immunology, Department of Medicine, University of 
      California, Irvine, Irvine, CA, United States.
LA  - eng
GR  - R01 AG045216/AG/NIA NIH HHS/United States
GR  - UL1 TR000153/TR/NCATS NIH HHS/United States
GR  - UL1 TR001414/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20170726
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC5526855
OTO - NOTNLM
OT  - aging
OT  - dendritic cells
OT  - inflammation
OT  - mucosa
OT  - tolerance
EDAT- 2017/08/12 06:00
MHDA- 2017/08/12 06:01
PMCR- 2017/01/01
CRDT- 2017/08/12 06:00
PHST- 2017/04/11 00:00 [received]
PHST- 2017/07/13 00:00 [accepted]
PHST- 2017/08/12 06:00 [entrez]
PHST- 2017/08/12 06:00 [pubmed]
PHST- 2017/08/12 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2017.00896 [doi]
PST - epublish
SO  - Front Immunol. 2017 Jul 26;8:896. doi: 10.3389/fimmu.2017.00896. eCollection 
      2017.