PMID- 28799728
OWN - NLM
STAT- MEDLINE
DCOM- 20180503
LR  - 20210208
IS  - 1097-0339 (Electronic)
IS  - 1097-0339 (Linking)
VI  - 45
IP  - 10
DP  - 2017 Oct
TI  - The combined application of urinary liquid-based cytology with fluorescence in 
      situ hybridization and p16/Ki-67 dual immunostaining is valuable for improving 
      the early diagnosis of upper tract urothelial carcinomas.
PG  - 895-902
LID - 10.1002/dc.23796 [doi]
AB  - OBJECTIVES: To evaluate the diagnostic values of urine liquid-based cytology 
      (LBC), fluorescence in situ hybridization (FISH), and p16/Ki-67 dual 
      immunostaining in the detection of upper tract urothelial carcinomas (UTUCs). 
      METHODS: Sixty-one patients with UTUCs were retrospectively analyzed. All 
      patients were diagnosed both by urine cytology and by FISH, and histologically 
      confirmed as UTUCs. Thirty-two patients had been stained with p16/Ki-67 dual 
      labeling. RESULTS: The sensitivities for low-grade UTUCs (LGUTUCs) and high-grade 
      UTUCs (HGUTUCs) were 33.3% and 67.4% by LBC, 60% and 69.6% by FISH, and 12.5% and 
      66.7% by p16/Ki-67 dual labeling, respectively. CONCLUSIONS: Our results 
      indicated that LBC was more suitable to identify HGUTUCs, FISH was highly 
      valuable for predicting LGUTUCs, and p16/Ki-67 dual labeling was useful for 
      distinguishing HGUTUCs from LGUTUCs. The combined application of these methods 
      may improve the sensitivity or accuracy in the detection or diagnosis of UTUCs.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Sun, Xueqi
AU  - Sun X
AD  - Department of Pathology, the First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou 510080, People's Republic of China.
FAU - Liu, Xubin
AU  - Liu X
AD  - Department of Pathology, the First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou 510080, People's Republic of China.
FAU - Xia, Meng
AU  - Xia M
AD  - Department of Gynecology and Obstetrics, The First Affiliated Hospital, Sun 
      Yat-sen University, Guangzhou, People's Republic of China.
FAU - Yang, Shicong
AU  - Yang S
AD  - Department of Pathology, the First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou 510080, People's Republic of China.
FAU - Fei, Lingyan
AU  - Fei L
AD  - Department of Pathology, the First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou 510080, People's Republic of China.
FAU - Zhang, Mengqi
AU  - Zhang M
AD  - Department of Pathology, the First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou 510080, People's Republic of China.
FAU - Ma, Hanyu
AU  - Ma H
AD  - Department of Pathology, the First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou 510080, People's Republic of China.
FAU - Wang, Liantang
AU  - Wang L
AD  - Department of Pathology, the First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou 510080, People's Republic of China.
FAU - Chen, Shangwu
AU  - Chen S
AD  - State Key Laboratory for Biocontrol, Guangdong Key Laboratory of Pharmaceutical 
      Functional Genes, Key Laboratory of Gene Engineering of the Ministry of 
      Education, Department of Biochemistry, School of Life Sciences, Sun Yat-sen 
      University, Guangzhou, People's Republic of China.
FAU - Yu, Li
AU  - Yu L
AUID- ORCID: 0000-0001-8513-1883
AD  - Department of Pathology, the First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou 510080, People's Republic of China.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20170811
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
RN  - 0 (CDKN2A protein, human)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - 0 (Ki-67 Antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma/*pathology
MH  - Case-Control Studies
MH  - Cyclin-Dependent Kinase Inhibitor p16/*metabolism
MH  - Early Detection of Cancer/*methods/standards
MH  - Female
MH  - Humans
MH  - Immunoassay/methods/standards
MH  - In Situ Hybridization, Fluorescence/methods/standards
MH  - Ki-67 Antigen/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Molecular Diagnostic Techniques/*methods/standards
MH  - Urinary Bladder Neoplasms/*pathology
MH  - Urothelium/*pathology
OTO - NOTNLM
OT  - diagnosis
OT  - fluorescence in situ hybridization (FISH)
OT  - liquid-based cytology (LBC)
OT  - p16/Ki-67 dual labeling
OT  - upper tract urothelial carcinomas (UTUCs)
EDAT- 2017/08/12 06:00
MHDA- 2018/05/04 06:00
CRDT- 2017/08/12 06:00
PHST- 2017/06/14 00:00 [received]
PHST- 2017/07/10 00:00 [revised]
PHST- 2017/08/03 00:00 [accepted]
PHST- 2017/08/12 06:00 [pubmed]
PHST- 2018/05/04 06:00 [medline]
PHST- 2017/08/12 06:00 [entrez]
AID - 10.1002/dc.23796 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 2017 Oct;45(10):895-902. doi: 10.1002/dc.23796. Epub 2017 Aug 
      11.