PMID- 28800278
OWN - NLM
STAT- MEDLINE
DCOM- 20180508
LR  - 20220408
IS  - 1473-7760 (Electronic)
IS  - 1052-0295 (Linking)
VI  - 92
IP  - 6
DP  - 2017
TI  - The antidepressant-like effect of Ocimum basilicum in an animal model of 
      depression.
PG  - 390-401
LID - 10.1080/10520295.2017.1323276 [doi]
AB  - We investigated the efficacy of Ocimum basilicum (OB) essential oils for treating 
      depression related behavioral, biochemical and histopathological changes caused 
      by exposure to chronic unpredictable mild stress (CUMS) in mice and to explore 
      the mechanism underlying the pathology. Male albino mice were divided into four 
      groups: controls; CUMS; CUMS plus fluoxetine, the antidepressant administered for 
      pharmacological validation of OB; and CUMS plus OB. Behavioral tests included the 
      forced swim test (FST), elevated plus-maze (EPM) and the open  fi eld test (OFT); 
      these tests were performed at the end of the experiment. We assessed serum 
      corticosterone level, protein, gene and immunoexpression of brain-derived 
      neurotropic factor (BDNF) and glucocorticoid receptors (GRs) as well as 
      immunoexpression of glial fibrillary acidic protein (GFAP), Ki67, caspase-3 in 
      the hippocampus. CUMS caused depression in the mice as evidenced by prolonged 
      immobility in the FST, prolonged time spent in the open arms during the EPM test 
      and reduction of open field activity in the OFT. OB ameliorated the CUMS induced 
      depressive status. OB significantly reduced the corticosterone level and 
      up-regulated protein and gene expressions of BDNF and GR. OB reduced CUMS induced 
      hippocampal neuron atrophy and apoptosis, and increased the number of the 
      astrocytes and new nerve cells. OB significantly increased GFAP-positive cells as 
      well as BDNF and GR immunoexpression in the hippocampus.
FAU - Ali, S S
AU  - Ali SS
AD  - a Anatomy Department, Faculty of Medicine , King Abdulaziz University.
FAU - Abd El Wahab, M G
AU  - Abd El Wahab MG
AD  - b Anatomy Department, Faculty of Medicine for Girls , Al Azhar University.
AD  - c Faculty of Nurses , National Gard, King Saud University, Yousef Abdullatif 
      Jameel Chair of Prophetic Medical Applications (YAJCPMA), Faculty of Medicine, 
      King Abdulaziz University , Jeddah , Saudi Arabia.
FAU - Ayuob, N N
AU  - Ayuob NN
AD  - a Anatomy Department, Faculty of Medicine , King Abdulaziz University.
AD  - d Histology Department, Faculty of Medicine , Mansoura University , Mansoura , 
      Egypt.
FAU - Suliaman, M
AU  - Suliaman M
AD  - e Pharmacology Department, Faculty of Medicine , King Abdulaziz University , 
      Jeddah , Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20170811
PL  - England
TA  - Biotech Histochem
JT  - Biotechnic & histochemistry : official publication of the Biological Stain 
      Commission
JID - 9107378
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Oils, Volatile)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/chemistry/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Depression/*drug therapy
MH  - Disease Models, Animal
MH  - Hippocampus/*drug effects/pathology
MH  - Mice
MH  - Ocimum basilicum/*chemistry
MH  - Oils, Volatile/chemistry/*therapeutic use
MH  - Protein Binding/drug effects
MH  - Receptors, Glucocorticoid/genetics/metabolism
OTO - NOTNLM
OT  - Ocimum basilicum
OT  - apoptosis
OT  - brain-derived neurotropic factor (BDNF)
OT  - depression
OT  - glial fibrillary acidic protein (GFAP)
OT  - glucocorticoid receptors (GRs)
OT  - hippocampus
OT  - mice
OT  - neurogenesis
EDAT- 2017/08/12 06:00
MHDA- 2018/05/09 06:00
CRDT- 2017/08/12 06:00
PHST- 2017/08/12 06:00 [pubmed]
PHST- 2018/05/09 06:00 [medline]
PHST- 2017/08/12 06:00 [entrez]
AID - 10.1080/10520295.2017.1323276 [doi]
PST - ppublish
SO  - Biotech Histochem. 2017;92(6):390-401. doi: 10.1080/10520295.2017.1323276. Epub 
      2017 Aug 11.