PMID- 28800733
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20190115
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Aug 11
TI  - Integrative and quantitive evaluation of the efficacy of his bundle related 
      pacing in comparison with conventional right ventricular pacing: a meta-analysis.
PG  - 221
LID - 10.1186/s12872-017-0649-4 [doi]
LID - 221
AB  - BACKGROUND: Long-term RVP could bring adverse problems to cardiac 
      electro-mechanics and result in inter- and intra-ventricular asynchrony, impaired 
      labor force, and aggravation of cardiac function. HBRP including direct His 
      bundle pacing and para-His bundle pacing was regarded as a novel physiological 
      pacing pattern to avoid devastating cardiac function. This synthetic study was 
      conducted to integratively and quantitatively evaluate the efficacy of His bundle 
      related pacing (HBRP) in comparison with conventional right ventricular pacing 
      (RVP). METHODS: Published studies on comparison of left ventricular ejection 
      fraction (LVEF), left ventricular end diastolic volume (LVEDV), left ventricular 
      end systolic volume (LVESV), New York Heart Association (NYHA) class, 
      inter-ventricular asynchrony, and QRS duration, etc. between HBRP and RVP were 
      collected and for meta-analysis. RESULTS: HBRP showed higher LVEF (WMD = 3.9%, 
      95% CI: 1.6% - 6.1%), lower NYHA class (WMD = -0.5, 95% CI: -0.7 - -0.3), WMD of 
      LVESV = -0.1 ml, 95% CI: -3.0 - 2.8 ml), less inter-ventricular asynchrony 
      (WMD = -13.2 ms, 95% CI: -16.4 - -10.0 ms), and shorter QRS duration for 
      long-term (WMD = -36.9 ms, 95% CI: -40.0 - -33.8 ms), however, no significant 
      difference of ventricular volume (WMDLVEDV = -2.4 ml, 95% CI: -5.0 - 0.2 ml; 
      WMDLVESV = -0.1 ml, 95% CI: -3.0 - 2.8 ml) compared to RVP. CONCLUSIONS: The 
      efficacy of HBRP was firstly verified by meta-analysis to date. Compared with 
      RVP, HBRP markedly preserve LVEF, NYHA class, and QRS duration. However, it 
      seemed to have less effect on ventricular volume.
FAU - Yu, Ziqing
AU  - Yu Z
AD  - Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, 
      Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of 
      China.
AD  - Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic 
      of China.
FAU - Chen, Ruizhen
AU  - Chen R
AD  - Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, 
      Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of 
      China.
AD  - Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai 
      Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 
      Shanghai, 200032, China.
FAU - Su, Yangang
AU  - Su Y
AD  - Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, 
      Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of 
      China. su.yangang@zs-hospital.sh.cn.
FAU - Chen, Xueying
AU  - Chen X
AD  - Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, 
      Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of 
      China.
FAU - Qin, Shengmei
AU  - Qin S
AD  - Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, 
      Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of 
      China.
FAU - Li, Minghui
AU  - Li M
AD  - Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, 
      Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of 
      China.
AD  - Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai 
      Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 
      Shanghai, 200032, China.
FAU - Han, Fei
AU  - Han F
AD  - Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, 
      Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of 
      China.
AD  - Shanghai Medical College, Fudan University, Shanghai, 200032, People's Republic 
      of China.
FAU - Ge, Junbo
AU  - Ge J
AUID- ORCID: 0000-0002-6655-1337
AD  - Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, 
      Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of 
      China. ge.junbo@zs-hospital.sh.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170811
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
SB  - IM
MH  - Action Potentials
MH  - Aged
MH  - Aged, 80 and over
MH  - Bradycardia/physiopathology/*therapy
MH  - Bundle of His/*physiopathology
MH  - Cardiac Pacing, Artificial/*methods
MH  - Female
MH  - *Heart Rate
MH  - Heart Ventricles/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Stroke Volume
MH  - Time Factors
MH  - Ventricular Function, Left
MH  - *Ventricular Function, Right
PMC - PMC5553603
OTO - NOTNLM
OT  - Cardiac function
OT  - His bundle pacing
OT  - Left ventricular ejection fraction
OT  - Meta-analysis
OT  - Right ventricular pacing
OT  - para-his bundle pacing
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Not applicable. CONSENT TO PUBLISH: 
      Not applicable. COMPETING INTERESTS: The authors declare that they have no 
      competing interest. PUBLISHER'S NOTE: Springer Nature remains neutral with regard 
      to jurisdictional claims in published maps and institutional affiliations.
EDAT- 2017/08/13 06:00
MHDA- 2018/01/09 06:00
PMCR- 2017/08/11
CRDT- 2017/08/13 06:00
PHST- 2017/03/24 00:00 [received]
PHST- 2017/07/27 00:00 [accepted]
PHST- 2017/08/13 06:00 [entrez]
PHST- 2017/08/13 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
PHST- 2017/08/11 00:00 [pmc-release]
AID - 10.1186/s12872-017-0649-4 [pii]
AID - 649 [pii]
AID - 10.1186/s12872-017-0649-4 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2017 Aug 11;17(1):221. doi: 10.1186/s12872-017-0649-4.