PMID- 28801088
OWN - NLM
STAT- MEDLINE
DCOM- 20170918
LR  - 20220408
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 119
IP  - 3
DP  - 2017 Sep
TI  - Characteristics of severe asthma with fungal sensitization.
PG  - 253-257
LID - S1081-1206(17)30548-3 [pii]
LID - 10.1016/j.anai.2017.07.008 [doi]
AB  - BACKGROUND: Some patients with severe asthma also have fungal sensitization and 
      are considered to have severe asthma with fungal sensitization. However, there is 
      limited information on the clinical features of SAFS. OBJECTIVE: To investigate 
      the clinical characteristics of severe asthma with fungal sensitization. METHODS: 
      The present study enrolled 124 patients with severe asthma. We evaluated clinical 
      aspects, such as various serum cytokines, fractional exhaled nitric oxide, 
      pulmonary function, and serum immunoglobulin E (IgE). Fungal sensitization was 
      assessed by determining serum levels of IgE specific to fungal allergens 
      (Aspergillus, Alternaria, Candida, Cladosporium, Penicillium, and Trichophyton 
      species and Schizophyllum commune). The protocol was registered at a clinical 
      trial registry (www.umin.ac.jp/ctr/index-j.htm; UMIN 000002980). RESULTS: 
      Thirty-six patients (29%) showed sensitization to at least 1 fungal allergen. The 
      most common species were Candida (16%), Aspergillus (11%), and Trichophyton 
      (11%). The rate of early-onset asthma (<16 years of age) was higher in patients 
      with fungal sensitization than in those without fungal sensitization (45% vs 25%; 
      P = .02). Interleukin-33 levels were higher in patients with fungal sensitization 
      than in those without fungal sensitization. Of patients with atopic asthma, 
      Asthma Control Test scores were worse in patients with multiple fungal 
      sensitizations than in patients with a single fungal sensitization or those 
      without fungal sensitization. CONCLUSION: Severe asthma with fungal sensitization 
      is characterized by early onset of disease and high serum levels of 
      interleukin-33. Multiple fungal sensitizations are associated with poor asthma 
      control. TRIAL REGISTRATION: UMIN Clinical Trials Registry (UMIN-CTR; 
      www.umin.ac.jp/ctr/index-j.htm): UMIN 000002980.
CI  - Copyright (c) 2017 American College of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Masaki, Katsunori
AU  - Masaki K
AD  - Division of Pulmonary Medicine, Department of Medicine, Keio University, School 
      of Medicine, Tokyo, Japan.
FAU - Fukunaga, Koichi
AU  - Fukunaga K
AD  - Division of Pulmonary Medicine, Department of Medicine, Keio University, School 
      of Medicine, Tokyo, Japan. Electronic address: km-fuku@cpnet.med.keio.ac.jp.
FAU - Matsusaka, Masako
AU  - Matsusaka M
AD  - Division of Pulmonary Medicine, Department of Medicine, Keio University, School 
      of Medicine, Tokyo, Japan.
FAU - Kabata, Hiroki
AU  - Kabata H
AD  - Division of Pulmonary Medicine, Department of Medicine, Keio University, School 
      of Medicine, Tokyo, Japan.
FAU - Tanosaki, Takae
AU  - Tanosaki T
AD  - Division of Pulmonary Medicine, Department of Medicine, Keio University, School 
      of Medicine, Tokyo, Japan.
FAU - Mochimaru, Takao
AU  - Mochimaru T
AD  - Division of Pulmonary Medicine, Department of Medicine, Keio University, School 
      of Medicine, Tokyo, Japan.
FAU - Kamatani, Takashi
AU  - Kamatani T
AD  - Division of Pulmonary Medicine, Department of Medicine, Keio University, School 
      of Medicine, Tokyo, Japan.
FAU - Ohtsuka, Kengo
AU  - Ohtsuka K
AD  - Division of Pulmonary Medicine, Department of Medicine, Keio University, School 
      of Medicine, Tokyo, Japan.
FAU - Baba, Rie
AU  - Baba R
AD  - Division of Pulmonary Medicine, Department of Medicine, Keio University, School 
      of Medicine, Tokyo, Japan.
FAU - Ueda, Soichiro
AU  - Ueda S
AD  - Division of Pulmonary Medicine, Department of Medicine, Keio University, School 
      of Medicine, Tokyo, Japan.
FAU - Suzuki, Yusuke
AU  - Suzuki Y
AD  - Department of Respiratory Medicine, Kitasato Institute Hospital, Tokyo, Japan.
FAU - Sakamaki, Fumio
AU  - Sakamaki F
AD  - Division of Pulmonary Medicine, Department of Medicine, Tokai University Hachioji 
      Hospital, Tokyo, Japan.
FAU - Oyamada, Yoshitaka
AU  - Oyamada Y
AD  - Department of Respiratory Medicine, Tokyo Medical Center, Tokyo, Japan.
FAU - Inoue, Takashi
AU  - Inoue T
AD  - Department of Medicine, Sano Kosei General Hospital, Tochigi, Japan.
FAU - Oguma, Tsuyoshi
AU  - Oguma T
AD  - Division of Pulmonary Medicine, Department of Medicine, Tokai University, School 
      of Medicine, Kanagawa, Japan.
FAU - Sayama, Koichi
AU  - Sayama K
AD  - Department of Medicine, Kawasaki Municipal Hospital, Kanagawa, Japan.
FAU - Koh, Hidefumi
AU  - Koh H
AD  - Department of Medicine, KKR-Tachikawa Hospital, Tokyo, Japan.
FAU - Nakamura, Morio
AU  - Nakamura M
AD  - Department of Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
FAU - Umeda, Akira
AU  - Umeda A
AD  - Department of Medicine, Shioya Hospital, International University of Health and 
      Welfare, Tochigi, Japan.
FAU - Kamei, Katsuhiko
AU  - Kamei K
AD  - Medical Mycology Research Center, Chiba University, Chiba, Japan.
FAU - Izuhara, Kenji
AU  - Izuhara K
AD  - Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga 
      Medical School, Saga, Japan.
FAU - Asano, Koichiro
AU  - Asano K
AD  - Division of Pulmonary Medicine, Department of Medicine, Tokai University, School 
      of Medicine, Kanagawa, Japan.
FAU - Betsuyaku, Tomoko
AU  - Betsuyaku T
AD  - Division of Pulmonary Medicine, Department of Medicine, Keio University, School 
      of Medicine, Tokyo, Japan.
LA  - eng
SI  - UMIN CTR/UMIN 000002980
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170808
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Allergens)
RN  - 0 (Antigens, Fungal)
RN  - 0 (Cytokines)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Allergens/*immunology
MH  - Antigens, Fungal/*immunology
MH  - Asthma/blood/*epidemiology/metabolism/physiopathology
MH  - Cytokines/blood
MH  - Female
MH  - Forced Expiratory Volume
MH  - Fungi/immunology
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/metabolism
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2017/08/13 06:00
MHDA- 2017/09/19 06:00
CRDT- 2017/08/13 06:00
PHST- 2017/04/25 00:00 [received]
PHST- 2017/06/11 00:00 [revised]
PHST- 2017/07/05 00:00 [accepted]
PHST- 2017/08/13 06:00 [pubmed]
PHST- 2017/09/19 06:00 [medline]
PHST- 2017/08/13 06:00 [entrez]
AID - S1081-1206(17)30548-3 [pii]
AID - 10.1016/j.anai.2017.07.008 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2017 Sep;119(3):253-257. doi: 
      10.1016/j.anai.2017.07.008. Epub 2017 Aug 8.