PMID- 28801374
OWN - NLM
STAT- MEDLINE
DCOM- 20180223
LR  - 20180223
IS  - 1550-8080 (Electronic)
IS  - 0091-7370 (Linking)
VI  - 47
IP  - 4
DP  - 2017 Aug
TI  - Myeloid Sarcoma in a Patient with Myelodysplastic Syndrome Associated with 
      del(5q-): Case Report and Literature Review.
PG  - 466-473
AB  - OBJECTIVE: Myeloid sarcoma (MS) is defined in the World Health Organization 
      classification as a tumor mass consisting of myeloblasts with or without 
      maturation and involving any anatomic site other than the bone marrow. We present 
      a case of MS developing in a patient with 5q- myelodysplastic syndrome (MDS) and 
      review the relevant literature. METHODS: A 77-year-old woman with recent 
      diagnosis of MDS associated with del(5q) presented with symptoms and signs 
      attributable to a mass involving the T8 vertebra. Biopsy of the spinal mass was 
      performed and the specimen was analyzed using routine hematoxylin-eosin stain, 
      immunohistochemical methods, and fluorescence in situ hybridization (FISH). 
      RESULTS: Microscopic examination revealed an infiltrate of intermediate-large 
      cells with basophilic cytoplasm and nuclei containing occasional prominent 
      nucleoli. Immunohistochemical analysis showed that the neoplastic cells were 
      positive for CD4, CD43, CD45, CD68, and CD117, and negative for B- and T-cell 
      antigens supporting the diagnosis of MS. Fluorescence in situ hybridization of 
      the spinal mass showed del(5q) in the neoplastic cells. CONCLUSION: Although the 
      5q- syndrome is a clinically indolent form of MDS, a small subset of patients may 
      develop MS as illustrated in this patient. The relevant literature is also 
      reviewed.
CI  - (c) 2017 by the Association of Clinical Scientists, Inc.
FAU - Showalter, Josh A
AU  - Showalter JA
AD  - Department of Pathology and Laboratory Medicine, UTHealth McGovern Medical 
      School, Houston, Texas, USA Josh.A.Showalter@uth.tmc.edu.
FAU - Tandon, Nidhi
AU  - Tandon N
AD  - Department of Pathology and Laboratory Medicine, UTHealth McGovern Medical 
      School, Houston, Texas, USA.
FAU - Zhao, Bihong
AU  - Zhao B
AD  - Department of Pathology and Laboratory Medicine, UTHealth McGovern Medical 
      School, Houston, Texas, USA.
FAU - Tang, Guilin
AU  - Tang G
AD  - Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 
      Houston, Texas, USA.
FAU - Nguyen, Nghia D
AU  - Nguyen ND
AD  - Department of Pathology and Laboratory Medicine, UTHealth McGovern Medical 
      School, Houston, Texas, USA.
FAU - Medeiros, L Jeffrey
AU  - Medeiros LJ
AD  - Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 
      Houston, Texas, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
RN  - Chromosome 5q Deletion Syndrome
SB  - IM
MH  - Aged
MH  - Anemia, Macrocytic/*genetics
MH  - Chromosome Deletion
MH  - *Chromosomes, Human, Pair 5/genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Prognosis
MH  - Sarcoma, Myeloid/*genetics
EDAT- 2017/08/13 06:00
MHDA- 2018/02/24 06:00
CRDT- 2017/08/13 06:00
PHST- 2017/08/13 06:00 [entrez]
PHST- 2017/08/13 06:00 [pubmed]
PHST- 2018/02/24 06:00 [medline]
AID - 47/4/466 [pii]
PST - ppublish
SO  - Ann Clin Lab Sci. 2017 Aug;47(4):466-473.