PMID- 28802494
OWN - NLM
STAT- MEDLINE
DCOM- 20171201
LR  - 20181202
IS  - 1557-9832 (Electronic)
IS  - 0272-2712 (Linking)
VI  - 37
IP  - 3
DP  - 2017 Sep
TI  - Toward a Molecular-Genetic Classification of Spitzoid Neoplasms.
PG  - 431-448
LID - S0272-2712(17)30039-2 [pii]
LID - 10.1016/j.cll.2017.05.003 [doi]
AB  - The histopathologic spectrum of Spitzoid neoplasms includes Spitz nevi, atypical 
      Spitz tumors, and Spitzoid melanomas. Advances in molecular genetics have evolved 
      to the point that Spitzoid lesions can now be reasonably classified according to 
      their distinctive molecular-genetic alterations: Spitzoid lesions with (1) 11p 
      amplification and/or HRAS mutations; (2) isolated loss of 6q23 by fluorescence in 
      situ hybridization (FISH); (3) homozygous deletion of 9p21 by FISH; (4) BAP1 loss 
      and BRAFV600 E mutation; (5) translocations involving any of a number of 
      different oncogenic kinase drivers, including ROS1, ALK, NTRK1, NTRK3, MET, BRAF, 
      and RET; and (6) TERT promoter mutations.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Tetzlaff, Michael T
AU  - Tetzlaff MT
AD  - Section of Dermatopathology, Department of Pathology, The University of Texas MD 
      Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 85, Houston, TX, USA; 
      Department of Translational and Molecular Pathology, The University of Texas MD 
      Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 85, Houston, TX, USA. 
      Electronic address: mtetzlaff@mdanderson.org.
FAU - Reuben, Alexandre
AU  - Reuben A
AD  - Department of Surgical Oncology, The University of Texas MD Anderson Cancer 
      Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
FAU - Billings, Steven D
AU  - Billings SD
AD  - Department of Pathology, Cleveland Clinic, 9500 Euclid Avenue L25, Cleveland, OH, 
      USA.
FAU - Prieto, Victor G
AU  - Prieto VG
AD  - Section of Dermatopathology, Department of Pathology, The University of Texas MD 
      Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 85, Houston, TX, USA; 
      Department of Dermatology, The University of Texas MD Anderson Cancer Center, 
      1515 Holcombe Boulevard, Unit 85, Houston, TX, USA.
FAU - Curry, Jonathan L
AU  - Curry JL
AD  - Section of Dermatopathology, Department of Pathology, The University of Texas MD 
      Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 85, Houston, TX, USA; 
      Department of Dermatology, The University of Texas MD Anderson Cancer Center, 
      1515 Holcombe Boulevard, Unit 85, Houston, TX, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Clin Lab Med
JT  - Clinics in laboratory medicine
JID - 8100174
SB  - IM
MH  - Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 3
MH  - Chromosomes, Human, Pair 6
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Melanoma/classification/genetics/pathology
MH  - Mutation
MH  - Nevus, Epithelioid and Spindle Cell/classification/*genetics/*pathology
MH  - Skin Neoplasms/classification/*genetics/*pathology
OTO - NOTNLM
OT  - Atypical Spitz tumor
OT  - BAP1
OT  - Comparative genomic hybridization
OT  - Fluorescence in situ hybridization
OT  - HRAS
OT  - Spitz nevus
OT  - Spitzoid melanoma
OT  - Telomerase promoter
EDAT- 2017/08/15 06:00
MHDA- 2017/12/02 06:00
CRDT- 2017/08/14 06:00
PHST- 2017/08/14 06:00 [entrez]
PHST- 2017/08/15 06:00 [pubmed]
PHST- 2017/12/02 06:00 [medline]
AID - S0272-2712(17)30039-2 [pii]
AID - 10.1016/j.cll.2017.05.003 [doi]
PST - ppublish
SO  - Clin Lab Med. 2017 Sep;37(3):431-448. doi: 10.1016/j.cll.2017.05.003.