PMID- 28802508
OWN - NLM
STAT- MEDLINE
DCOM- 20170914
LR  - 20201218
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 120
IP  - 7
DP  - 2017 Oct 1
TI  - Prognostic Significance of Left Ventricular Fibrosis in Patients With Congenital 
      Bicuspid Aortic Valve.
PG  - 1176-1179
LID - S0002-9149(17)31122-0 [pii]
LID - 10.1016/j.amjcard.2017.06.060 [doi]
AB  - This study sought to evaluate the prognostic value of left ventricular (LV) 
      fibrosis assessed by late gadolinium enhancement (LGE) of the myocardium during 
      cardiac magnetic resonance (CMR) imaging in patients with bicuspid aortic valve 
      (BAV), which is associated with early aortic valve fibrosis and calcification. To 
      what degree the LV myocardial wall is affected by fibrosis and its prognostic 
      value is currently unknown. This is a retrospective, single-center study 
      evaluating all adult patients with BAV who had CMR and followed from March 2002 
      to March 2016. CMR and transthoracic echocardiogram images were reviewed. 
      Clinical data were abstracted from the electronic medical record. A total of 29 
      patients were included in the study, of which 11 (38%) had CMR studies that 
      demonstrated the presence of LGE. Patients with LGE had significantly higher 
      aortic valve mean gradients by echocardiography when compared with LGE-negative 
      patients (30.3 +/- 7.2 mm Hg vs 14.7 +/- 3.6 mm Hg, p = 0.049). They were also more 
      likely to have LV hypertrophy. Patients with LGE were 10 times more likely to 
      need aortic valve replacement within 1 year of the CMR study than did patients 
      without LGE (55% vs 5.5%, p = 0.0028). In conclusion, evaluation of LGE by CMR as 
      a marker of LV myocardial fibrosis can have additional prognostic value when 
      evaluating patients with aortic stenosis secondary to BAV.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Lluri, Gentian
AU  - Lluri G
AD  - Ahmanson-UCLA Adult Congenital Heart Disease Center, Division of Cardiology, 
      Department of Medicine, David Geffen School of Medicine, University of California 
      at Los Angeles, Los Angeles, California.
FAU - Renella, Pierangelo
AU  - Renella P
AD  - Ahmanson-UCLA Adult Congenital Heart Disease Center, Division of Cardiology, 
      Department of Medicine, David Geffen School of Medicine, University of California 
      at Los Angeles, Los Angeles, California; Division of Radiological Sciences, David 
      Geffen School of Medicine at UCLA, Los Angeles, California.
FAU - Finn, J Paul
AU  - Finn JP
AD  - Ahmanson-UCLA Adult Congenital Heart Disease Center, Division of Cardiology, 
      Department of Medicine, David Geffen School of Medicine, University of California 
      at Los Angeles, Los Angeles, California; Division of Radiological Sciences, David 
      Geffen School of Medicine at UCLA, Los Angeles, California.
FAU - Vorobiof, Gabriel
AU  - Vorobiof G
AD  - Division of Cardiology, Department of Medicine, David Geffen School of Medicine, 
      University of California at Los Angeles, Los Angeles, California.
FAU - Aboulhosn, Jamil
AU  - Aboulhosn J
AD  - Ahmanson-UCLA Adult Congenital Heart Disease Center, Division of Cardiology, 
      Department of Medicine, David Geffen School of Medicine, University of California 
      at Los Angeles, Los Angeles, California.
FAU - Deb, Arjun
AU  - Deb A
AD  - Division of Cardiology, Department of Medicine, David Geffen School of Medicine, 
      University of California at Los Angeles, Los Angeles, California. Electronic 
      address: adeb@mednet.ucla.edu.
LA  - eng
GR  - R01 HL129178/HL/NHLBI NIH HHS/United States
GR  - R01 HL137241/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20170714
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Adult
MH  - Aortic Valve/*abnormalities
MH  - Bicuspid Aortic Valve Disease
MH  - Echocardiography
MH  - Female
MH  - Fibrosis
MH  - Heart Valve Diseases/complications/*congenital/diagnosis
MH  - Heart Ventricles/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Myocardium/*pathology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Severity of Illness Index
PMC - PMC5593788
MID - NIHMS892957
EDAT- 2017/08/15 06:00
MHDA- 2017/09/15 06:00
PMCR- 2018/10/01
CRDT- 2017/08/14 06:00
PHST- 2017/04/18 00:00 [received]
PHST- 2017/06/12 00:00 [revised]
PHST- 2017/06/29 00:00 [accepted]
PHST- 2017/08/15 06:00 [pubmed]
PHST- 2017/09/15 06:00 [medline]
PHST- 2017/08/14 06:00 [entrez]
PHST- 2018/10/01 00:00 [pmc-release]
AID - S0002-9149(17)31122-0 [pii]
AID - 10.1016/j.amjcard.2017.06.060 [doi]
PST - ppublish
SO  - Am J Cardiol. 2017 Oct 1;120(7):1176-1179. doi: 10.1016/j.amjcard.2017.06.060. 
      Epub 2017 Jul 14.