PMID- 28802586
OWN - NLM
STAT- MEDLINE
DCOM- 20180614
LR  - 20201209
IS  - 1769-714X (Electronic)
IS  - 1286-4579 (Linking)
VI  - 19
IP  - 11
DP  - 2017 Nov
TI  - Nontypeable Haemophilus influenzae (NTHi) directly interfere with the regulation 
      of E-cadherin in lung epithelial cells.
PG  - 560-566
LID - S1286-4579(17)30116-8 [pii]
LID - 10.1016/j.micinf.2017.07.002 [doi]
AB  - Loss of epithelial barriers characterized by reduction of E-cadherin is a 
      hallmark of chronic obstructive pulmonary disease (COPD). We investigated the 
      effects of nontypeable Haemophilus influenzae (NTHi) infections, associated with 
      acute exacerbations of chronic bronchitis, on the regulation of E-cadherin in 
      host cells. NTHi infection decreased E-cadherin mRNA and protein-levels in lung 
      epithelial cells. E-cadherin reduction was mediated by activation of the 
      fibroblast growth factor 2 (FGF2), the mammalian target of rapamycin (mTOR) and 
      Slug. These data indicate that epithelial integrity and barrier function is 
      disturbed by NTHi infection. Mainly, the destruction of cell-cell contacts is a 
      prominent feature in NTHi infection.
CI  - Copyright (c) 2017 Institut Pasteur. Published by Elsevier Masson SAS. All rights 
      reserved.
FAU - Kaufhold, Inga
AU  - Kaufhold I
AD  - Department of Infectious Diseases and Microbiology, University of Lubeck, 
      Ratzeburger Allee 160, 23538 Lubeck, Germany. Electronic address: 
      inga.kaufhold@uksh.de.
FAU - Osbahr, Sunja
AU  - Osbahr S
AD  - Department of Infectious Diseases and Microbiology, University of Lubeck, 
      Ratzeburger Allee 160, 23538 Lubeck, Germany.
FAU - Shima, Kensuke
AU  - Shima K
AD  - Department of Infectious Diseases and Microbiology, University of Lubeck, 
      Ratzeburger Allee 160, 23538 Lubeck, Germany.
FAU - Marwitz, Sebastian
AU  - Marwitz S
AD  - Clinical and Experimental Pathology, Research Center Borstel, Parkallee 1-40, 
      23845 Borstel, Germany; Airway Research Center North (ARCN), German Center for 
      Lung Research, Wohrendamm 80, 22927 Grobetahansdorf, Germany.
FAU - Rohmann, Kristina
AU  - Rohmann K
AD  - Medical Clinic III, University Hospital Schleswig-Holstein, Campus Lubeck, 
      Ratzeburger Allee 160, 23538 Lubeck, Germany.
FAU - Dromann, Daniel
AU  - Dromann D
AD  - Medical Clinic III, University Hospital Schleswig-Holstein, Campus Lubeck, 
      Ratzeburger Allee 160, 23538 Lubeck, Germany; Airway Research Center North 
      (ARCN), German Center for Lung Research, Wohrendamm 80, 22927 Grobetahansdorf, 
      Germany.
FAU - Goldmann, Torsten
AU  - Goldmann T
AD  - Clinical and Experimental Pathology, Research Center Borstel, Parkallee 1-40, 
      23845 Borstel, Germany; Airway Research Center North (ARCN), German Center for 
      Lung Research, Wohrendamm 80, 22927 Grobetahansdorf, Germany.
FAU - Dalhoff, Klaus
AU  - Dalhoff K
AD  - Medical Clinic III, University Hospital Schleswig-Holstein, Campus Lubeck, 
      Ratzeburger Allee 160, 23538 Lubeck, Germany; Airway Research Center North 
      (ARCN), German Center for Lung Research, Wohrendamm 80, 22927 Grobetahansdorf, 
      Germany.
FAU - Rupp, Jan
AU  - Rupp J
AD  - Department of Infectious Diseases and Microbiology, University of Lubeck, 
      Ratzeburger Allee 160, 23538 Lubeck, Germany.
LA  - eng
PT  - Journal Article
DEP - 20170810
PL  - France
TA  - Microbes Infect
JT  - Microbes and infection
JID - 100883508
RN  - 0 (Cadherins)
RN  - 0 (Zonula Occludens-1 Protein)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
SB  - IM
MH  - A549 Cells/microbiology
MH  - Blotting, Western
MH  - Cadherins/*metabolism
MH  - Fibroblast Growth Factor 2/metabolism
MH  - Haemophilus Infections/*metabolism/microbiology
MH  - *Haemophilus influenzae
MH  - Humans
MH  - Lung/*microbiology
MH  - Microscopy, Fluorescence
MH  - Real-Time Polymerase Chain Reaction
MH  - Respiratory Mucosa/*microbiology
MH  - Zonula Occludens-1 Protein/metabolism
OTO - NOTNLM
OT  - COPD
OT  - E-cadherin
OT  - Nontypeable Haemophilus influenzae
EDAT- 2017/08/15 06:00
MHDA- 2018/06/15 06:00
CRDT- 2017/08/14 06:00
PHST- 2017/05/08 00:00 [received]
PHST- 2017/07/28 00:00 [revised]
PHST- 2017/07/31 00:00 [accepted]
PHST- 2017/08/15 06:00 [pubmed]
PHST- 2018/06/15 06:00 [medline]
PHST- 2017/08/14 06:00 [entrez]
AID - S1286-4579(17)30116-8 [pii]
AID - 10.1016/j.micinf.2017.07.002 [doi]
PST - ppublish
SO  - Microbes Infect. 2017 Nov;19(11):560-566. doi: 10.1016/j.micinf.2017.07.002. Epub 
      2017 Aug 10.