PMID- 2880443
OWN - NLM
STAT- MEDLINE
DCOM- 19870306
LR  - 20190716
IS  - 0001-5598 (Print)
IS  - 0001-5598 (Linking)
VI  - 114
IP  - 1
DP  - 1987 Jan
TI  - Parathyroid hormone release in vitro in hyperparathyroidism associated with 
      multiple endocrine neoplasia type 1.
PG  - 12-7
AB  - Hyperparathyroidism (HPT) in the syndrome of multiple endocrine neoplasia type 1 
      (MEN-1) exhibits a different picture regarding its propensity for recurrence 
      compared with sporadic primary HPT. In order to shed further light on the MEN-1 
      syndrome an investigation in vitro was made of parathyroid hormone (PTH) release 
      of dispersed parathyroid cell from 11 patients with parathyroid hyperplasia 
      associated with MEN-1, 10 patients with single parathyroid adenomas, and 10 
      preparations of normal bovine parathyroid glands. The two patient groups had the 
      same average serum calcium value prior to surgery. Immunoreactive concentrations 
      of PTH were measured after 2-h incubations at extracellular calcium 
      concentrations of 0.5-3.0 mmol/l. Compared with the normal bovine parathyroid 
      cells, the cells of the MEN-1 patients had a reduced calcium sensitivity of the 
      PTH release and secreted smaller amounts of hormone at both low and high 
      extracellular calcium concentrations. A similar abnormality of the PTH release 
      was found for the cells of the hyperplastic and adenomatous parathyroid glands. 
      Although individual parathyroid glands were investigated in only three MEN-1 
      patients, the results suggested the secretory regulation to be less defective in 
      the small glands of each patient. It is concluded that in patient groups matched 
      for serum calcium, the parathyroid tissue of MEN-1 patients has an abnormality of 
      the PTH release similar to that of parathyroid adenomas.
FAU - Benson, L
AU  - Benson L
FAU - Rastad, J
AU  - Rastad J
FAU - Ljunghall, S
AU  - Ljunghall S
FAU - Rudberg, C
AU  - Rudberg C
FAU - Akerstrom, G
AU  - Akerstrom G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Acta Endocrinol (Copenh)
JT  - Acta endocrinologica
JID - 0370312
RN  - 0 (Parathyroid Hormone)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adenoma/complications/*metabolism
MH  - Calcium/blood
MH  - Humans
MH  - Hyperparathyroidism/complications/*physiopathology
MH  - Hyperplasia
MH  - Multiple Endocrine Neoplasia/complications/*metabolism
MH  - Organ Size
MH  - Parathyroid Glands/pathology
MH  - Parathyroid Hormone/*metabolism
MH  - Parathyroid Neoplasms/complications/*metabolism
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
AID - 10.1530/acta.0.1140012 [doi]
PST - ppublish
SO  - Acta Endocrinol (Copenh). 1987 Jan;114(1):12-7. doi: 10.1530/acta.0.1140012.