PMID- 2880645
OWN - NLM
STAT- MEDLINE
DCOM- 19870330
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 401
IP  - 2
DP  - 1987 Jan 20
TI  - Inhibition of gastric acid secretion by immunoneutralization of endogenous brain 
      thyrotropin-releasing hormone.
PG  - 381-4
AB  - Previous studies have shown that intracisternal (i.c.), but not intravenous 
      administration of thyrotropin-releasing hormone (TRH), an endogenous tripeptide 
      (pGlu-His-Pro-NH2), produces a time-, dose-dependent and vagus-mediated 
      stimulation of acid secretion in rats. This study was designed to test the 
      hypothesis that endogenous brain TRH plays a role in regulation of acid secretion 
      in the pylorus-ligation model. In confirmation of previous reports, i.c. TRH (1 
      microgram) significantly (P less than 0.01) stimulated gastric acid output, 
      gastric secretory volume and decreased gastric intraluminal pH. 
      Intracerebroventricular (i.c.v.) infusion of TRH antiserum (anti-TRH) 30 min 
      prior to pyloric occlusion significantly reduced acid output, secretory volume 
      and raised gastric pH. This inhibitory gastric acid secretory response to i.c.v. 
      anti-TRH appears to be specific since i.c.v. infusion of normal rabbit serum or 
      antisera raised against neurotensin (NT), Leu-enkephalin (L-enk), 
      gonadotropin-releasing hormone (GnRH), somatostatin (SRIF) and alpha-melanocyte 
      stimulating hormone (alpha-MSH) were without measurable effect. The findings of 
      this study indicate that endogenous brain TRH, but not NT, L-enk, GnRH, SRIF or 
      alpha-MSH plays a physiological role in regulation of acid secretion.
FAU - Hernandez, D E
AU  - Hernandez DE
FAU - Jennes, L
AU  - Jennes L
FAU - Emerick, S G
AU  - Emerick SG
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Pituitary Hormone-Releasing Hormones)
RN  - 39379-15-2 (Neurotensin)
RN  - 51110-01-1 (Somatostatin)
RN  - 58822-25-6 (Enkephalin, Leucine)
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
RN  - 9002-79-3 (Melanocyte-Stimulating Hormones)
SB  - IM
MH  - Animals
MH  - Brain/*physiology
MH  - Enkephalin, Leucine/physiology
MH  - Gastric Acid/*metabolism
MH  - Gastric Mucosa/*metabolism
MH  - Male
MH  - Melanocyte-Stimulating Hormones/physiology
MH  - Neurotensin/physiology
MH  - Pituitary Hormone-Releasing Hormones/physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Somatostatin/metabolism
MH  - Thyrotropin-Releasing Hormone/*physiology
EDAT- 1987/01/20 00:00
MHDA- 1987/01/20 00:01
CRDT- 1987/01/20 00:00
PHST- 1987/01/20 00:00 [pubmed]
PHST- 1987/01/20 00:01 [medline]
PHST- 1987/01/20 00:00 [entrez]
AID - 0006-8993(87)91425-9 [pii]
AID - 10.1016/0006-8993(87)91425-9 [doi]
PST - ppublish
SO  - Brain Res. 1987 Jan 20;401(2):381-4. doi: 10.1016/0006-8993(87)91425-9.