PMID- 28806535
OWN - NLM
STAT- MEDLINE
DCOM- 20180705
LR  - 20221207
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 42
IP  - 12
DP  - 2017 Dec
TI  - Interactions between genetic polymorphisms of glucose metabolizing genes and 
      smoking and alcohol consumption in the risk of type 2 diabetes mellitus.
PG  - 1316-1321
LID - 10.1139/apnm-2017-0232 [doi]
AB  - The impact of gene-environment interaction on diabetes remains largely unknown. 
      We aimed to investigate if interaction between glucose metabolizing genes and 
      lifestyle factors is associated with type 2 diabetes mellitus (T2DM). 
      Interactions between genotypes of 4 glucose metabolizing genes (MTNR1B, KCNQ1, 
      KLF14, and GCKR) and lifestyle factors were estimated in 722 T2DM patients and 
      759 controls, using multiple logistic regression. No significant associations 
      with T2DM were detected for the single nucleotide polymorphisms of MTNR1B, KLF14 
      and GCKR. However, rs151290 (KCNQ1) polymorphisms were found to be associated 
      with risk of T2DM. Compared with AA, the odds ratios (ORs) of AC or CC genotypes 
      for developing T2DM were 1.545 (P = 0.0489) and 1.603 (P = 0.0383), respectively. 
      In stratified analyses, the associations were stronger in smokers with CC than 
      smokers with AA (OR = 3.668, P = 0.013); drinkers with AC (OR = 5.518, P = 
      0.036), CC (OR = 8.691, P = 0.0095), and AC+CC (OR = 6.764, P = 0.016) than 
      drinkers with AA. Compared with nondrinkers with AA, drinkers who carry AC and CC 
      had 12.072-fold (P = 0.0007) and 8.147-fold (P = 0.0052) higher risk of 
      developing T2DM. In conclusions, rs151290 (KCNQ1) polymorphisms are associated 
      with increased risk of T2DM, alone and especially in interaction with smoking and 
      alcohol.
FAU - Gao, Kaiping
AU  - Gao K
AD  - a Department of Preventive Medicine, Shenzhen University School of Medicine, 3688 
      Nanhai Road, Shenzhen, 518060, China.
FAU - Ren, Yongcheng
AU  - Ren Y
AD  - b Department of Epidemiology, College of Public Health, Zhengzhou University, 
      Zhengzhou, 450001, China.
FAU - Wang, Jinjin
AU  - Wang J
AD  - c Department of Traditional Chinese Medicine Prevention, Preventive Medicine 
      Research Evaluation Center, Henan University of Traditional Chinese Medicine, 
      Zhengzhou, 450001, China.
FAU - Liu, Zichen
AU  - Liu Z
AD  - a Department of Preventive Medicine, Shenzhen University School of Medicine, 3688 
      Nanhai Road, Shenzhen, 518060, China.
FAU - Li, Jianna
AU  - Li J
AD  - a Department of Preventive Medicine, Shenzhen University School of Medicine, 3688 
      Nanhai Road, Shenzhen, 518060, China.
FAU - Li, Linlin
AU  - Li L
AD  - b Department of Epidemiology, College of Public Health, Zhengzhou University, 
      Zhengzhou, 450001, China.
FAU - Wang, Bingyuan
AU  - Wang B
AD  - b Department of Epidemiology, College of Public Health, Zhengzhou University, 
      Zhengzhou, 450001, China.
FAU - Li, Hong
AU  - Li H
AD  - a Department of Preventive Medicine, Shenzhen University School of Medicine, 3688 
      Nanhai Road, Shenzhen, 518060, China.
FAU - Wang, Yaxi
AU  - Wang Y
AD  - a Department of Preventive Medicine, Shenzhen University School of Medicine, 3688 
      Nanhai Road, Shenzhen, 518060, China.
FAU - Cao, Yunkai
AU  - Cao Y
AD  - a Department of Preventive Medicine, Shenzhen University School of Medicine, 3688 
      Nanhai Road, Shenzhen, 518060, China.
FAU - Ohno, Kinji
AU  - Ohno K
AD  - d Division of Neurogenetics, Center for Neurological Diseases and Cancer, 
      University Graduate School of Medicine, Nagoya, 4668550, Japan.
FAU - Zhai, Rihong
AU  - Zhai R
AD  - a Department of Preventive Medicine, Shenzhen University School of Medicine, 3688 
      Nanhai Road, Shenzhen, 518060, China.
FAU - Liang, Zhen
AU  - Liang Z
AD  - e Department of Geriatric Medicine, The 1st Affiliated Hospital of Shenzhen 
      University, 3002 West Sungang Road, Shenzhen, 518035, China.
LA  - eng
PT  - Journal Article
DEP - 20170814
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - *Alcohol Drinking
MH  - Asian People
MH  - Diabetes Mellitus, Type 2/etiology/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Glucose/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - *Smoking
OTO - NOTNLM
OT  - Chinese population
OT  - KCNQ1
OT  - alcohol
OT  - alcool
OT  - diabete de type 2
OT  - gene-environment interaction
OT  - glucose metabolizing genes
OT  - genes du metabolisme du glucose
OT  - interaction gene-environnement
OT  - polymorphismes
OT  - polymorphisms
OT  - population chinoise
OT  - smoking
OT  - tabagisme
OT  - type 2 diabetes mellitus
EDAT- 2017/08/15 06:00
MHDA- 2018/07/06 06:00
CRDT- 2017/08/15 06:00
PHST- 2017/08/15 06:00 [pubmed]
PHST- 2018/07/06 06:00 [medline]
PHST- 2017/08/15 06:00 [entrez]
AID - 10.1139/apnm-2017-0232 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2017 Dec;42(12):1316-1321. doi: 10.1139/apnm-2017-0232. 
      Epub 2017 Aug 14.