PMID- 28807548
OWN - NLM
STAT- MEDLINE
DCOM- 20171012
LR  - 20181202
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1515
DP  - 2017 Sep 15
TI  - Application of a simple column-switching ion chromatography technique for removal 
      of matrix interferences and sensitive fluorescence determination of acidic 
      compounds (pharmaceutical drugs) in complex samples.
PG  - 69-80
LID - S0021-9673(17)30974-3 [pii]
LID - 10.1016/j.chroma.2017.07.007 [doi]
AB  - This work illustrates the introduction of a simple, rugged and flexible 
      column-switching ion chromatography (IC) technique for an automated on-line 
      QuEChERS extracted samples extracts washing followed by sensitive fluorescence 
      (FLD) determination of five acidic pharmaceutical drugs namely; clofibric acid 
      (CLO), ibuprofen (IBU), aspirin (ASP), naproxen (NAP) and flurobrofen (FLU) in 
      three complex samples (spinach, apple and hospital sewage sludge). An old anion 
      exchange column IonPac((R)) AS11-HC was utilized as a pre-treatment column for 
      on-line washing of inorganic and organic interferences followed by isocratic 
      separation of five acidic drugs with another anion exchange IonPac((R)) AS12A 
      analytical column by exploiting the column-switching technique. This novel method 
      exhibited good linearity with correlation coefficients (r(2)) for all drugs were 
      in the range 0.976-0.996. The limit of detection and quantification of all five 
      acidic drugs were in the range 0.024mug/kg to 8.70mug/kg and 0.082mug/kg to 
      0.029mg/kg, respectively, and better recoveries in the range 81.17-112.5% with 
      percentage relative standard deviations (RSDs) less than 17.8% were obtained. 
      This on-line sample pre-treatment method showed minimum matrix effect in the 
      range of 0.87-1.25 except for aspirin. This simple rugged and flexible 
      column-switching system required only 28min for maximum elimination of matrices 
      and interferences in three complex samples extracts, isocratic separation of five 
      acidic drugs and for the continuous regeneration of pre-treatment column prior to 
      every subsequent analysis. Finally, this simple automated IC system was appeared 
      so rugged and flexible, which can eliminate and wash out most of interference, 
      impurities and matrices in complex samples, simply by adjusting the NaOH and 
      acetonitrile concentration in washing mobile phase with maximum recoveries of 
      acidic analytes of interest.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Muhammad, Nadeem
AU  - Muhammad N
AD  - Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou 310028, 
      China.
FAU - Subhani, Qamar
AU  - Subhani Q
AD  - Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou 310028, 
      China; Higher Education Department, Punjab, Lahore, Pakistan.
FAU - Wang, Fenglian
AU  - Wang F
AD  - Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou 310028, 
      China.
FAU - Guo, Dandan
AU  - Guo D
AD  - Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou 310028, 
      China.
FAU - Zhao, Qiming
AU  - Zhao Q
AD  - Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou 310028, 
      China.
FAU - Wu, Shuchao
AU  - Wu S
AD  - Zhejiang Institute of Geology and Mineral Resources, Hangzhou 310007, Zhejiang, 
      China. Electronic address: wushch2002@163.com.
FAU - Zhu, Yan
AU  - Zhu Y
AD  - Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou 310028, 
      China. Electronic address: zhuyan@zju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170705
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Acids)
RN  - 0 (Complex Mixtures)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Acids/*analysis
MH  - Chemistry Techniques, Analytical/*methods
MH  - *Chromatography, Ion Exchange
MH  - Complex Mixtures/chemistry
MH  - Fluorescence
MH  - Limit of Detection
MH  - Pharmaceutical Preparations/*analysis
OTO - NOTNLM
OT  - Acidic pharmaceutical drugs
OT  - Column switching
OT  - Fluorescence detection
OT  - Ion chromatography
OT  - On-line
OT  - QuEChERS
EDAT- 2017/08/16 06:00
MHDA- 2017/10/13 06:00
CRDT- 2017/08/16 06:00
PHST- 2017/04/24 00:00 [received]
PHST- 2017/06/27 00:00 [revised]
PHST- 2017/07/03 00:00 [accepted]
PHST- 2017/08/16 06:00 [pubmed]
PHST- 2017/10/13 06:00 [medline]
PHST- 2017/08/16 06:00 [entrez]
AID - S0021-9673(17)30974-3 [pii]
AID - 10.1016/j.chroma.2017.07.007 [doi]
PST - ppublish
SO  - J Chromatogr A. 2017 Sep 15;1515:69-80. doi: 10.1016/j.chroma.2017.07.007. Epub 
      2017 Jul 5.