PMID- 28808352
OWN - NLM
STAT- MEDLINE
DCOM- 20190305
LR  - 20190305
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Aug 14
TI  - The effect of androgen excess on maternal metabolism, placental function and 
      fetal growth in obese dams.
PG  - 8066
LID - 10.1038/s41598-017-08559-w [doi]
LID - 8066
AB  - Pregnant women with polycystic ovary syndrome (PCOS) are often overweight or 
      obese. To study the effects of maternal androgen excess in obese dams on 
      metabolism, placental function and fetal growth, female C57Bl6J mice were fed a 
      control (CD) or a high fat/high sucrose (HF/HS) diet for 4-10 weeks, and then 
      mated. On gestational day (GD) 15.5-17.5, dams were injected with 
      dihydrotestosterone (CD-DHT, HF/HS-DHT) or a vehicle (CD-Veh, HF/HS-Veh). HF/HS 
      dams had higher fat content, both before mating and on GD18.5, with no difference 
      in glucose homeostasis, whereas the insulin sensitivity was higher in DHT-exposed 
      dams. Compared to the CD groups, the livers from HF/HS dams weighed more on 
      GD18.5, the triglyceride content was higher, and there was a dysregulation of 
      liver enzymes related to lipogenesis and higher mRNA expression of Fitm1. Fetuses 
      from HF/HS-Veh dams had lower liver triglyceride content and mRNA expression of 
      Srebf1c. Maternal DHT exposure, regardless of diet, decreased fetal liver Pparg 
      mRNA expression and increased placental androgen receptor protein expression. 
      Maternal diet-induced obesity, together with androgen excess, affects maternal 
      and fetal liver function as demonstrated by increased triglyceride content and 
      dysfunctional expression of enzymes and transcription factors involved in de novo 
      lipogenesis and fat storage.
FAU - Fornes, Romina
AU  - Fornes R
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, 171 77, 
      Stockholm, Sweden.
FAU - Maliqueo, Manuel
AU  - Maliqueo M
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, 171 77, 
      Stockholm, Sweden.
AD  - Endocrinology and Metabolism Laboratory, Department of Medicine, West Division, 
      University of Chile, Santiago, Chile.
FAU - Hu, Min
AU  - Hu M
AD  - Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska 
      Academy, University of Gothenburg, Gothenburg, Sweden.
FAU - Hadi, Laila
AU  - Hadi L
AD  - Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska 
      Academy, University of Gothenburg, Gothenburg, Sweden.
FAU - Jimenez-Andrade, Juan M
AU  - Jimenez-Andrade JM
AD  - Unidad Academica Multidisciplinaria Reynosa Aztlan, Universidad Autonoma de 
      Tamaulipas, Reynosa, Tamaulipas, Mexico.
FAU - Ebefors, Kerstin
AU  - Ebefors K
AD  - Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska 
      Academy, University of Gothenburg, Gothenburg, Sweden.
FAU - Nystrom, Jenny
AU  - Nystrom J
AD  - Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska 
      Academy, University of Gothenburg, Gothenburg, Sweden.
FAU - Labrie, Fernand
AU  - Labrie F
AD  - Laval University Research Center in Molecular Endocrinology, Oncology and Human 
      Genomics, CHUL Research Center, Quebec, G1V 4G2, Canada.
FAU - Jansson, Thomas
AU  - Jansson T
AD  - Department of Obstetrics & Gynecology, Division of Reproductive Sciences, 
      University Colorado Anschutz Medical Campus, Aurora, Colorado, 80045, USA.
FAU - Benrick, Anna
AU  - Benrick A
AD  - Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska 
      Academy, University of Gothenburg, Gothenburg, Sweden.
AD  - School of Health and Education, University of Skovde, 54128, Skovde, Sweden.
FAU - Stener-Victorin, Elisabet
AU  - Stener-Victorin E
AUID- ORCID: 0000-0002-3424-1502
AD  - Department of Physiology and Pharmacology, Karolinska Institutet, 171 77, 
      Stockholm, Sweden. elisabet.stener-victorin@ki.se.
LA  - eng
GR  - P30 DK048520/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170814
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Androgens)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Androgens/*metabolism
MH  - Animals
MH  - Diet, High-Fat/adverse effects
MH  - Female
MH  - Fetal Development/*physiology
MH  - Fetus/metabolism
MH  - Insulin Resistance/physiology
MH  - Lipogenesis/physiology
MH  - Male
MH  - Maternal Nutritional Physiological Phenomena/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Obesity/*metabolism/*physiopathology
MH  - Overweight/metabolism/physiopathology
MH  - Placenta/*metabolism/*physiopathology
MH  - Polycystic Ovary Syndrome/metabolism/physiopathology
MH  - Pregnancy
MH  - Pregnancy Complications/metabolism/physiopathology
MH  - Triglycerides/metabolism
PMC - PMC5556034
COIS- The authors declare that they have no competing interests.
EDAT- 2017/08/16 06:00
MHDA- 2019/03/06 06:00
PMCR- 2017/08/14
CRDT- 2017/08/16 06:00
PHST- 2017/03/31 00:00 [received]
PHST- 2017/07/11 00:00 [accepted]
PHST- 2017/08/16 06:00 [entrez]
PHST- 2017/08/16 06:00 [pubmed]
PHST- 2019/03/06 06:00 [medline]
PHST- 2017/08/14 00:00 [pmc-release]
AID - 10.1038/s41598-017-08559-w [pii]
AID - 8559 [pii]
AID - 10.1038/s41598-017-08559-w [doi]
PST - epublish
SO  - Sci Rep. 2017 Aug 14;7(1):8066. doi: 10.1038/s41598-017-08559-w.