PMID- 28808643
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 2277-9175 (Print)
IS  - 2277-9175 (Electronic)
IS  - 2277-9175 (Linking)
VI  - 6
DP  - 2017
TI  - Polymorphism (rs16917496) at the miR-502 Binding Site of the Lysine 
      Methyltransferase 5A (SET8) and Its Correlation with Colorectal Cancer in 
      Iranians.
PG  - 77
LID - 10.4103/2277-9175.210656 [doi]
LID - 77
AB  - BACKGROUND: One of the gene expression regulatory mechanisms is mediated by small 
      noncoding RNAs called microRNA (miRNA). They interact with a recognition sequence 
      located mostly in 3'-untranslated regions (3'-UTRs) of mRNAs. Polymorphisms in 
      miRNAs recognition sequences could affect gene expression which in turn may alter 
      disease susceptibility. SET8, a member of the SET domain-containing 
      methyltransferase, acts in a variety of biological processes such as genomic 
      stability. Here, we report correlation of rs16917496 polymorphism, located in the 
      recognition sequence of miR-502 within 3'-UTR of SET8, with colorectal cancer 
      (CRC) in Iranians. MATERIALS AND METHODS: One hundred and seventy CRC patients 
      and 170 noncancer counterparts were recruited in this case-control study. 
      Genotyping of rs16917496 was performed using polymerase chain 
      reaction-restriction fragment length polymorphism method. RESULTS: There was no 
      significant association of rs16917496 with CRC in population under study (P value 
      for genotype and allele distribution were >0.05). However, stratification 
      analysis based on smoking status revealed that TT+TC genotypes of SET8 rs16917496 
      are strongly associated with increased risk of CRC (odds ratio: 5.8, 95% 
      confidence interval: 1.37-24.34, P - 0.005) in smoker subgroup. CONCLUSION: 
      Correlation of rs16917496 T allele with CRC in smokers is emphasizing the 
      importance of individuals' genotype in the recruitment of adverse health hazards 
      of smoking more profoundly for certain people compared to others.
FAU - Mosallayi, Meysam
AU  - Mosallayi M
AD  - Department of Genetics and Molecular Biology, School of Medicine, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
FAU - Simonian, Miganoosh
AU  - Simonian M
AD  - Department of Genetics and Molecular Biology, School of Medicine, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
FAU - Khosravi, Sharifeh
AU  - Khosravi S
AD  - Department of Genetics and Molecular Biology, School of Medicine, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
FAU - Salehi, Ahmad Reza
AU  - Salehi AR
AD  - Department of Genetics and Molecular Biology, School of Medicine, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
FAU - Khodadoostan, Mahsa
AU  - Khodadoostan M
AD  - Department of Internal Medicine, School of Medicine, Isfahan University of 
      Medical Sciences, Isfahan, Iran.
FAU - Sebghatollahi, Vahid
AU  - Sebghatollahi V
AD  - Department of Internal Medicine, School of Medicine, Isfahan University of 
      Medical Sciences, Isfahan, Iran.
FAU - Baradaran, Azar
AU  - Baradaran A
AD  - Department of Pathology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Salehi, Rasoul
AU  - Salehi R
AD  - Department of Genetics and Molecular Biology, School of Medicine, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
AD  - Department of Acquired Immunodeficiency Research Center, Isfahan University of 
      Medical Sciences, Isfahan, Iran.
AD  - Department of Gerfa Namayesh Azmayesh (GENAZMA) Science and Research Institute, 
      Isfahan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170714
PL  - India
TA  - Adv Biomed Res
JT  - Advanced biomedical research
JID - 101586897
PMC - PMC5539672
OTO - NOTNLM
OT  - Colorectal cancer
OT  - SET8 gene
OT  - microRNA
OT  - single-nucleotide polymorphism
COIS- There are no conflicts of interest.
EDAT- 2017/08/16 06:00
MHDA- 2017/08/16 06:01
PMCR- 2017/07/14
CRDT- 2017/08/16 06:00
PHST- 2017/08/16 06:00 [entrez]
PHST- 2017/08/16 06:00 [pubmed]
PHST- 2017/08/16 06:01 [medline]
PHST- 2017/07/14 00:00 [pmc-release]
AID - ABR-6-77 [pii]
AID - 10.4103/2277-9175.210656 [doi]
PST - epublish
SO  - Adv Biomed Res. 2017 Jul 14;6:77. doi: 10.4103/2277-9175.210656. eCollection 
      2017.