PMID- 28809430
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180719
LR  - 20180719
IS  - 2040-3372 (Electronic)
IS  - 2040-3364 (Linking)
VI  - 9
IP  - 34
DP  - 2017 Aug 31
TI  - A one step method for the functional and property modification of DOPA based 
      nanocoatings.
PG  - 12409-12415
LID - 10.1039/c7nr05293f [doi]
AB  - Biomimetic poly(catecholamine) coatings have gained much attention in recent 
      years due to their versatility as functional materials. Despite this, only 
      limited methods are available to modify the function and property of 
      poly(catecholamine) coatings, primarily through post-modification methods. Our 
      approach reported herein provides a simple approach to the fabrication of novel 
      functionalized poly(catecholamine) coatings. The strategy employs the 
      copolymerization of N-Ac-3,4-dihydroxyphenylalanine methyl ester (NADOPAMe) with 
      nucleophilic additives, giving rise to nano-coatings on various surfaces 
      including plastic, metal, glass and polymers. With the appropriate choice of 
      nucleophilic additives, coatings with desired properties can be achieved. This is 
      demonstrated through the fabrication of a redox responsive coating based on 
      NADOPAMe with cysteamine as additive, which shows a concentration-dependent 
      glutathione (GSH) responsive behavior. The ability to utilize this as a 
      controlled release system is also demonstrated.
FAU - Lyu, Qinghua
AU  - Lyu Q
AD  - Department of Pharmacy, National University of Singapore, 18 Science Drive 4, 
      Singapore 117543. phacllc@nus.edu.sg.
FAU - Zhang, Jieyu
AU  - Zhang J
AD  - Department of Chemical and Biomolecular Engineering, National University of 
      Singapore, 4 Engineering Drive 4, Singapore 117585.
FAU - Neoh, Koon Gee
AU  - Neoh KG
AUID- ORCID: 0000-0002-2700-1914
AD  - Department of Chemical and Biomolecular Engineering, National University of 
      Singapore, 4 Engineering Drive 4, Singapore 117585.
FAU - Li Lin Chai, Christina
AU  - Li Lin Chai C
AUID- ORCID: 0000-0002-9199-851X
AD  - Department of Pharmacy, National University of Singapore, 18 Science Drive 4, 
      Singapore 117543. phacllc@nus.edu.sg.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nanoscale
JT  - Nanoscale
JID - 101525249
EDAT- 2017/08/16 06:00
MHDA- 2017/08/16 06:01
CRDT- 2017/08/16 06:00
PHST- 2017/08/16 06:00 [pubmed]
PHST- 2017/08/16 06:01 [medline]
PHST- 2017/08/16 06:00 [entrez]
AID - 10.1039/c7nr05293f [doi]
PST - ppublish
SO  - Nanoscale. 2017 Aug 31;9(34):12409-12415. doi: 10.1039/c7nr05293f.