PMID- 28810562
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 14
IP  - 2
DP  - 2017 Aug
TI  - Anti-depressant-like effects of Jieyu chufan capsules in a mouse model of 
      unpredictable chronic mild stress.
PG  - 1086-1094
LID - 10.3892/etm.2017.4601 [doi]
AB  - Jieyu chufan (JYCF) is a well-known Chinese traditional medicine used for 
      depression; however, the molecular mechanism underlying its anti-depressant 
      action has remained elusive. In the present study, the anti-depressant effects of 
      JYCF and the potential mechanisms were investigated in a mouse model. Five groups 
      of 12 C57BL/6 mice each were used in the study, including a normal control group 
      (NC group), a model control group (MC group) and three groups, which received 
      different doses of JYCF (1.25, 2.5 and 5 g/kg) orally for 21 days (JYCF groups). 
      The MC group and the three JYCF groups were subjected to 3 weeks of unpredictable 
      chronic mild stress (UCMS) to induce depression-like behavior. All groups were 
      subjected to a sucrose consumption test along with a forced swimming test to 
      confirm depression-like behavior, an open-field test and an elevated plus maze 
      test to confirm anxiety-like behavior, and a Morris water maze test to evaluate 
      spatial learning and memory. In addition, synaptic density in the hippocampus was 
      evaluated and western blot and immunostaining were used to analyze hippocampal 
      expression of postsynaptic density protein-95 (PSD95), synaptophysin (Syn), 
      cyclic adenosine monophosphate response element binding protein (CREB), 
      brain-derived neurotrophic factor (BDNF), Akt and glycogen synthase kinase 
      (GSK)-3beta as well as their phosphorylated (p) versions. The results showed that 
      JYCF (2.5 and 5 g/kg) alleviated depressive-like behaviors and increased synaptic 
      density in UCMS mice. Moreover, JYCF upregulated the expression of PSD95, Syn and 
      BDNF and increased phosphorylated Akt, CREB and GSK-3beta in the hippocampus. These 
      results suggested that JYCF exerts an anti-depressant-like activity in 
      UCMS-induced mice, which is likely to be mediated by reversing the stress-induced 
      disruption of BDNF and GSK-3beta activity.
FAU - Zhao, Hui
AU  - Zhao H
AD  - Department of Neurology, Affiliated Drum Tower Hospital, Nanjing University 
      Medical School, Nanjing, Jiangsu 210008, P.R. China.
AD  - State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 
      Nanjing, Jiangsu 210008, P.R. China.
AD  - Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, 
      Nanjing, Jiangsu 210008, P.R. China.
AD  - Department of Neurology, Nanjing Clinic Medicine Center for Neurological and 
      Psychiatric Diseases, Nanjing, Jiangsu 210008, P.R. China.
FAU - Liang, Bingyu
AU  - Liang B
AD  - State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 
      Nanjing, Jiangsu 210008, P.R. China.
AD  - Department of Neurology, Affiliated Drum Tower Hospital, Nanjing University of 
      Chinese Medicine, Nanjing, Jiangsu 210008, P.R. China.
FAU - Yu, Linjie
AU  - Yu L
AD  - Department of Neurology, Affiliated Drum Tower Hospital, Nanjing University 
      Medical School, Nanjing, Jiangsu 210008, P.R. China.
AD  - State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 
      Nanjing, Jiangsu 210008, P.R. China.
AD  - Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, 
      Nanjing, Jiangsu 210008, P.R. China.
AD  - Department of Neurology, Nanjing Clinic Medicine Center for Neurological and 
      Psychiatric Diseases, Nanjing, Jiangsu 210008, P.R. China.
FAU - Xu, Yun
AU  - Xu Y
AD  - Department of Neurology, Affiliated Drum Tower Hospital, Nanjing University 
      Medical School, Nanjing, Jiangsu 210008, P.R. China.
AD  - State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 
      Nanjing, Jiangsu 210008, P.R. China.
AD  - Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, 
      Nanjing, Jiangsu 210008, P.R. China.
AD  - Department of Neurology, Nanjing Clinic Medicine Center for Neurological and 
      Psychiatric Diseases, Nanjing, Jiangsu 210008, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170614
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5525591
OTO - NOTNLM
OT  - Chinese traditional medicine
OT  - Jieyu chufan capsules
OT  - depression
OT  - unpredictable chronic mild stress
EDAT- 2017/08/16 06:00
MHDA- 2017/08/16 06:01
PMCR- 2017/06/14
CRDT- 2017/08/17 06:00
PHST- 2016/04/25 00:00 [received]
PHST- 2017/03/24 00:00 [accepted]
PHST- 2017/08/17 06:00 [entrez]
PHST- 2017/08/16 06:00 [pubmed]
PHST- 2017/08/16 06:01 [medline]
PHST- 2017/06/14 00:00 [pmc-release]
AID - ETM-0-0-4601 [pii]
AID - 10.3892/etm.2017.4601 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 Aug;14(2):1086-1094. doi: 10.3892/etm.2017.4601. Epub 2017 Jun 
      14.