PMID- 28810595
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 14
IP  - 2
DP  - 2017 Aug
TI  - SUDOSCAN, an effective tool for screening chronic kidney disease in patients with 
      type 2 diabetes.
PG  - 1343-1350
LID - 10.3892/etm.2017.4689 [doi]
AB  - SUDOSCAN is a non-invasive method of measuring peripheral small fiber and 
      autonomic nerve activity by detection of abnormal sweat gland function through 
      electrochemical skin conductance. It has been reported to be an effective 
      screening tool in early detection of microvascular type 2 diabetes mellitus 
      (T2DM) complications including diabetic neuropathy and nephropathy in recent 
      studies. However, previous studies used estimated glomerular filtration rate 
      (eGFR) as the golden standard, which has a 90% chance of being within 30% of the 
      measured GFR at best. No relevant study has been performed in the Chinese 
      population concerning SUDOSCAN in the screening of diabetic nephropathy (DN) in 
      comparison with GFR. In this cross-sectional study, SUDOSCAN was performed in 176 
      Chinese patients with T2DM between September 2014 and September 2015. It was 
      found that the SUDOSCAN test had a sensitivity of 57.8% and a specificity of 100% 
      to detect chronic kidney disease at a cut-off SUDOSCAN-DN score of 59.5. The area 
      under receiver operating characteristic curve for DN was 0.85 [95% confidence 
      interval (CI), 0.76-0.93] compared with 0.84 for eGFR(MDRD) (MDRD, modification 
      of diet in renal disease; 95% CI, 0.71-0.98) and 0.77 for eGFR(EPI) (EPI, 
      epidemiology collaboration; 95% CI, 0.68-0.87). Patients with DN score <59.5 had 
      a significantly lower GFR level (P<0.001) and significantly older age (P<0.001), 
      longer duration of T2DM (P<0.001) and higher risk of diabetic complications, 
      including diabetic neuropathy (P<0.001) and peripheral vascular disease (P<0.05). 
      These results suggested that SUDOSCAN may be useful for detecting patients at 
      risk of impaired renal function as part of a screening program in the Chinese 
      population with T2DM.
FAU - Mao, Fei
AU  - Mao F
AD  - Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 
      Shanghai 200040, P.R. China.
FAU - Liu, Siying
AU  - Liu S
AD  - Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 
      Shanghai 200040, P.R. China.
FAU - Qiao, Xiaona
AU  - Qiao X
AD  - Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 
      Shanghai 200040, P.R. China.
FAU - Zheng, Hangping
AU  - Zheng H
AD  - Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 
      Shanghai 200040, P.R. China.
FAU - Xiong, Qian
AU  - Xiong Q
AD  - Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 
      Shanghai 200040, P.R. China.
AD  - Department of Endocrinology and Metabolism, Jing'an Center Hospital of Shanghai, 
      Shanghai 200040, P.R. China.
FAU - Wen, Jie
AU  - Wen J
AD  - Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 
      Shanghai 200040, P.R. China.
AD  - Department of Endocrinology and Metabolism, Jing'an Center Hospital of Shanghai, 
      Shanghai 200040, P.R. China.
FAU - Zhang, Shuo
AU  - Zhang S
AD  - Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 
      Shanghai 200040, P.R. China.
FAU - Zhang, Zhaoyun
AU  - Zhang Z
AD  - Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 
      Shanghai 200040, P.R. China.
FAU - Ye, Hongying
AU  - Ye H
AD  - Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 
      Shanghai 200040, P.R. China.
FAU - Shi, Hongli
AU  - Shi H
AD  - Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 
      Shanghai 200040, P.R. China.
FAU - Lu, Bin
AU  - Lu B
AD  - Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 
      Shanghai 200040, P.R. China.
FAU - Li, Yiming
AU  - Li Y
AD  - Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, 
      Shanghai 200040, P.R. China.
AD  - Department of Endocrinology and Metabolism, Jing'an Center Hospital of Shanghai, 
      Shanghai 200040, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170627
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5525651
OTO - NOTNLM
OT  - SUDOSCAN
OT  - diabetic nephropathy
OT  - modification of diet in renal disease
OT  - screening
OT  - type 2 diabetes mellitus
EDAT- 2017/08/16 06:00
MHDA- 2017/08/16 06:01
PMCR- 2017/06/27
CRDT- 2017/08/17 06:00
PHST- 2016/05/09 00:00 [received]
PHST- 2017/03/23 00:00 [accepted]
PHST- 2017/08/17 06:00 [entrez]
PHST- 2017/08/16 06:00 [pubmed]
PHST- 2017/08/16 06:01 [medline]
PHST- 2017/06/27 00:00 [pmc-release]
AID - ETM-0-0-4689 [pii]
AID - 10.3892/etm.2017.4689 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 Aug;14(2):1343-1350. doi: 10.3892/etm.2017.4689. Epub 2017 Jun 
      27.