PMID- 28810641
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 14
IP  - 2
DP  - 2017 Aug
TI  - Allicin improves carotid artery intima-media thickness in coronary artery disease 
      patients with hyperhomocysteinemia.
PG  - 1722-1726
LID - 10.3892/etm.2017.4698 [doi]
AB  - Homocysteine (Hcy) is an important and independent risk factor for 
      atherosclerotic diseases, such as coronary artery disease and ischemic 
      cerebrovascular disease. Increased carotid artery intima-media thickness (IMT) is 
      a non-invasive marker of systemic atherosclerosis. Allicin treatment may decrease 
      serum Hcy levels and improve impaired endothelial function in rats with 
      hyperhomocysteinemia (HHcy). The present study hypothesized that allicin has an 
      anti-atherosclerotic effect in coronary heart disease and tested the effects of 
      allicin treatment on carotid artery IMT and plasma Hcy levels in coronary heart 
      disease patients with HHcy. Sixty-two coronary heart disease patients with HHcy 
      were randomly divided into an allicin group and a control group. All patients 
      underwent diagnostic assessment, plasma Hcy assay, blood lipid measurement and 
      B-mode ultrasound of the carotid artery prior to and after treatment. Plasma Hcy 
      levels were determined by high-performance liquid chromatography and fluorescence 
      detection. Carotid artery IMT was calculated using an automated algorithm based 
      on a validated edge-detection technique. After 12 weeks, significant decreases in 
      carotid artery IMT, plasma Hcy levels, total cholesterol and triglycerides were 
      observed in the allicin group (all P<0.05), and the decreases in the allicin 
      group were significantly greater than those in the control group (all P<0.01). 
      These findings suggested that reducing plasma Hcy levels may be useful for 
      preventing the generation and development of atherosclerosis in patients with 
      coronary heart disease. Allicin was able to decrease Hcy levels, total 
      cholesterol and triglycerides as well as carotid artery IMT.
FAU - Liu, De-Shan
AU  - Liu DS
AD  - Department of Traditional Chinese Medicine, Qilu Hospital of Shandong University, 
      Jinan, Shandong 250012, P.R. China.
FAU - Wang, Shu-Li
AU  - Wang SL
AD  - Department of Geriatrics, Linyi People's Hospital, Linyi, Shandong 276003, P.R. 
      China.
FAU - Li, Jun-Mei
AU  - Li JM
AD  - Department of Cardiovascular Medicine, Penglai Traditional Chinese Medicine 
      Hospital of Shandong, Penglai, Shandong 265600, P.R. China.
FAU - Liang, Er-Shun
AU  - Liang ES
AD  - Department of Traditional Chinese Medicine, Qilu Hospital of Shandong University, 
      Jinan, Shandong 250012, P.R. China.
FAU - Yan, Ming-Zhong
AU  - Yan MZ
AD  - Department of Cardiovascular Medicine, Penglai Traditional Chinese Medicine 
      Hospital of Shandong, Penglai, Shandong 265600, P.R. China.
FAU - Gao, Wei
AU  - Gao W
AD  - Department of Traditional Chinese Medicine, Qilu Hospital of Shandong University, 
      Jinan, Shandong 250012, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170628
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5526167
OTO - NOTNLM
OT  - B-mode ultrasonographic scanning
OT  - allicin
OT  - carotid artery intima-media thickness
OT  - coronary heart disease
OT  - hyperhomocysteinemia
EDAT- 2017/08/16 06:00
MHDA- 2017/08/16 06:01
PMCR- 2017/06/28
CRDT- 2017/08/17 06:00
PHST- 2015/08/30 00:00 [received]
PHST- 2017/01/26 00:00 [accepted]
PHST- 2017/08/17 06:00 [entrez]
PHST- 2017/08/16 06:00 [pubmed]
PHST- 2017/08/16 06:01 [medline]
PHST- 2017/06/28 00:00 [pmc-release]
AID - ETM-0-0-4698 [pii]
AID - 10.3892/etm.2017.4698 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 Aug;14(2):1722-1726. doi: 10.3892/etm.2017.4698. Epub 2017 Jun 
      28.