PMID- 28811298
OWN - NLM
STAT- MEDLINE
DCOM- 20180508
LR  - 20180725
IS  - 1479-6821 (Electronic)
IS  - 1351-0088 (Linking)
VI  - 24
IP  - 10
DP  - 2017 Oct
TI  - The future: surgical advances in MEN1 therapeutic approaches and management 
      strategies.
PG  - T243-T260
LID - 10.1530/ERC-17-0285 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN1) is a hereditary autosomal dominant 
      disorder associated with numerous neuroendocrine tumors (NETs). Recent advances 
      in the management of MEN1 have led to a decrease in mortality due to excess 
      hormones; however, they have also led to an increase in mortality from 
      malignancy, particularly NETs. The main challenges are to localize these tumors, 
      to select those that need therapy because of the risk of aggressive behavior and 
      to select the appropriate therapy associated with minimal morbidity. This must be 
      applied to a hereditary disease with a high risk of recurrence. The overall aim 
      of management in MEN1 is to ensure that the patient remains disease- and 
      symptom-free for as long as possible and maintains a good quality of life. 
      Herein, we review the changes that occurred in the last 20 years in the surgical 
      management of MEN1-associated functional and non-functional pancreatico-duodenal 
      NETs and thymic and bronchial NETs.
CI  - (c) 2017 Society for Endocrinology.
FAU - Sadowski, S M
AU  - Sadowski SM
AD  - Thoracic and Endocrine Surgery and Faculty of MedicineUniversity Hospitals of 
      Geneva, Geneva, Switzerland.
FAU - Cadiot, G
AU  - Cadiot G
AD  - Gastroenterology and HepatologyUniversity Hospital of Reims, Reims, France.
FAU - Dansin, E
AU  - Dansin E
AD  - OncologyOscar Lambret Cancer Center, University of Lille, Lille, France.
FAU - Goudet, P
AU  - Goudet P
AD  - Endocrine SurgeryUniversity Hospital of Dijon, and INSERM, U866, Epidemiology and 
      Clinical Research in Digestive Oncology Team, and INSERM, CIC1432, Clinical 
      Epidemiology Unit, University Hospital of Dijon, Clinical Investigation Centre, 
      Clinical Epidemiology/Clinical Trials Unit, Dijon, France.
FAU - Triponez, F
AU  - Triponez F
AD  - Thoracic and Endocrine Surgery and Faculty of MedicineUniversity Hospitals of 
      Geneva, Geneva, Switzerland frederic.triponez@hcuge.ch.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170815
PL  - England
TA  - Endocr Relat Cancer
JT  - Endocrine-related cancer
JID - 9436481
SB  - IM
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/pathology/*surgery
MH  - Neuroendocrine Tumors/pathology/*surgery
OTO - NOTNLM
OT  - lung NET
OT  - multiple endocrine neoplasia type 1 (MEN1)
OT  - neuro-endocrine tumors (NET)
OT  - pancreatico-gastro-intestinal NET
OT  - thymic NET
EDAT- 2017/08/16 06:00
MHDA- 2018/05/09 06:00
CRDT- 2017/08/17 06:00
PHST- 2017/08/07 00:00 [received]
PHST- 2017/08/15 00:00 [accepted]
PHST- 2017/08/16 06:00 [pubmed]
PHST- 2018/05/09 06:00 [medline]
PHST- 2017/08/17 06:00 [entrez]
AID - ERC-17-0285 [pii]
AID - 10.1530/ERC-17-0285 [doi]
PST - ppublish
SO  - Endocr Relat Cancer. 2017 Oct;24(10):T243-T260. doi: 10.1530/ERC-17-0285. Epub 
      2017 Aug 15.