PMID- 28811686
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231104
IS  - 0970-1915 (Print)
IS  - 0974-0422 (Electronic)
IS  - 0970-1915 (Linking)
VI  - 32
IP  - 3
DP  - 2017 Jul
TI  - Influence of the Flavonoid, Quercetin on Antioxidant Status, Lipid Peroxidation 
      and Histopathological Changes in Hyperammonemic Rats.
PG  - 275-284
LID - 10.1007/s12291-016-0603-8 [doi]
AB  - We have studied the ability of quercetin (a bioflavonoid) in tackling oxidative 
      stress to alleviate the symptoms during ammonium chloride-induced hyperammonemia. 
      Hyperammonemia was induced by the treatment of ammonium chloride (AC) 100 mg/kg 
      b.w for 56 days. Hyperammonemic rats exhibited reduced urea (in plasma) and 
      increased ammonia (in blood), uric acid (in plasma), creatinine (in serum), 
      oxidative stress markers (thiobarbituric acid reactive substances (TBARS) and 
      hydroperoxides (HP) and decreased levels of antioxidants (enzymatic and 
      non-enzymatic) superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase 
      (GPx), reduced glutathione (GSH) in plasma and tissues (liver and brain) vitamins 
      E and C (in plasma)). The expression of liver inflammatory markers such as, 
      interleukin 6 (IL-6), inducible nitric oxide synthase (iNOS) and nuclear 
      transcription factor-kappaB (NF-kappaB) (by western blotting) were investigated. 
      Histological damages (in liver, brain and kidney) were observed under 
      hyperammonemia and the administration of quercetin (1) normalized the 
      histopathological alterations, (2) reduced the levels of TBARS and HP, (3) 
      elevated the antioxidants (SOD, CAT, GPx, GSH, vitamins E and C), (4) declined 
      the activities of liver marker enzymes (AST, ALT and ALP) and (5) down regulated 
      the expression of IL-6, iNOS and NF-kappaB. Our results suggest that quercetin might 
      exert defense to AC-induced hyperammonemic rats to tackle (1) oxidative stress 
      and (2) inflammation owing to its antioxidant, anti-inflammatory and 
      cytoprotective effects.
FAU - Kanimozhi, Sivamani
AU  - Kanimozhi S
AD  - Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai 
      University, Annamalainagar, Chidambaram, Tamil Nadu 608 002 India. ISNI: 0000 
      0001 2369 7742. GRID: grid.411408.8
FAU - Bhavani, Pakkiri
AU  - Bhavani P
AD  - Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai 
      University, Annamalainagar, Chidambaram, Tamil Nadu 608 002 India. ISNI: 0000 
      0001 2369 7742. GRID: grid.411408.8
FAU - Subramanian, Perumal
AU  - Subramanian P
AUID- ORCID: 0000-0003-0908-8232
AD  - Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai 
      University, Annamalainagar, Chidambaram, Tamil Nadu 608 002 India. ISNI: 0000 
      0001 2369 7742. GRID: grid.411408.8
LA  - eng
PT  - Journal Article
DEP - 20160811
PL  - India
TA  - Indian J Clin Biochem
JT  - Indian journal of clinical biochemistry : IJCB
JID - 8708303
PMC - PMC5539000
OTO - NOTNLM
OT  - Ammonium chloride
OT  - Antioxidant
OT  - Hyperammonaemia
OT  - Lipid peroxidation
OT  - Quercetin
COIS- The authors declare that there is no conflict of interest.
EDAT- 2017/08/16 06:00
MHDA- 2017/08/16 06:01
PMCR- 2018/07/01
CRDT- 2017/08/17 06:00
PHST- 2016/04/29 00:00 [received]
PHST- 2016/08/04 00:00 [accepted]
PHST- 2017/08/17 06:00 [entrez]
PHST- 2017/08/16 06:00 [pubmed]
PHST- 2017/08/16 06:01 [medline]
PHST- 2018/07/01 00:00 [pmc-release]
AID - 603 [pii]
AID - 10.1007/s12291-016-0603-8 [doi]
PST - ppublish
SO  - Indian J Clin Biochem. 2017 Jul;32(3):275-284. doi: 10.1007/s12291-016-0603-8. 
      Epub 2016 Aug 11.