PMID- 28812058
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 2333-794X (Print)
IS  - 2333-794X (Electronic)
IS  - 2333-794X (Linking)
VI  - 4
DP  - 2017
TI  - Environmental Pollutants and Neurodevelopment: Review of Benefits From Closure of 
      a Coal-Burning Power Plant in Tongliang, China.
PG  - 2333794X17721609
LID - 10.1177/2333794X17721609 [doi]
LID - 2333794X17721609
AB  - Background. Understanding preventable causes of neurodevelopmental disorders is a 
      public health priority. Polycyclic aromatic hydrocarbons (PAH) from combustion of 
      fossil fuel, lead, and mercury are among known neurodevelopmental toxicants. 
      Method. For the first time, we comprehensively review the findings from a study 
      by the Columbia Center for Children's Environmental Health and Chinese partners 
      that followed 2 groups of mother-child pairs, one from 2002 and another from 
      2005, in Tongliang County, China. Pregnant mothers in the 2 cohorts experienced 
      different exposure to PAH because a local coal-burning power plant was shut down 
      in 2004. Investigators assessed change in prenatal PAH exposure, measured using a 
      biomarker (benzo[a]pyrene [BaP]-DNA adducts in cord blood). Developmental 
      quotients were measured using the Gesell Developmental Scales at age 2 and IQ was 
      assessed using the Wechsler Intelligence Scale for Children at age 5. Biologic 
      markers of preclinical response were measured in cord blood: methylation status 
      of long interspersed nuclear elements (LINE1), an indicator of genomic stability, 
      and brain-derived neurotrophic factor (BDNF), a neuronal growth promoter. 
      Analyses accounted for co-exposure to lead and mercury. Results. BaP-DNA adducts 
      were significantly inversely associated with Gesell Developmental Scales scores 
      in the first cohort but not in the second cohort; and levels of BDNF and LINE1 
      methylation were higher in the second cohort. Conclusion. In this study, reduced 
      exposure to PAH was associated with beneficial effects on neurodevelopment as 
      well as molecular changes related to improved brain development and health. These 
      benefits should encourage further efforts to limit exposure to these toxic 
      pollutants.
FAU - Kalia, Vrinda
AU  - Kalia V
AD  - Department of Environmental Health Sciences, Columbia Center for Children's 
      Environemental Health, Mailman School of Public Health, Columbia University, New 
      York, NY, USA.
FAU - Perera, Frederica
AU  - Perera F
AD  - Department of Environmental Health Sciences, Columbia Center for Children's 
      Environemental Health, Mailman School of Public Health, Columbia University, New 
      York, NY, USA.
FAU - Tang, Deliang
AU  - Tang D
AD  - Department of Environmental Health Sciences, Columbia Center for Children's 
      Environemental Health, Mailman School of Public Health, Columbia University, New 
      York, NY, USA.
LA  - eng
PT  - Journal Article
DEP - 20170731
PL  - United States
TA  - Glob Pediatr Health
JT  - Global pediatric health
JID - 101670224
PMC - PMC5542072
OTO - NOTNLM
OT  - LINE1 methylation
OT  - brain-derived neurotrophic factor
OT  - coal-burning power plant
OT  - neurodevelopment
OT  - polycyclic aromatic hydrocarbons
OT  - prenatal exposure
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2017/08/16 06:00
MHDA- 2017/08/16 06:01
PMCR- 2017/07/31
CRDT- 2017/08/17 06:00
PHST- 2016/10/07 00:00 [received]
PHST- 2017/06/13 00:00 [revised]
PHST- 2017/06/21 00:00 [accepted]
PHST- 2017/08/17 06:00 [entrez]
PHST- 2017/08/16 06:00 [pubmed]
PHST- 2017/08/16 06:01 [medline]
PHST- 2017/07/31 00:00 [pmc-release]
AID - 10.1177_2333794X17721609 [pii]
AID - 10.1177/2333794X17721609 [doi]
PST - epublish
SO  - Glob Pediatr Health. 2017 Jul 31;4:2333794X17721609. doi: 
      10.1177/2333794X17721609. eCollection 2017.