PMID- 28812173
OWN - NLM
STAT- MEDLINE
DCOM- 20180710
LR  - 20220321
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 40
IP  - 6
DP  - 2017 Dec
TI  - Melatonin Attenuates Pain Hypersensitivity and Decreases Astrocyte-Mediated 
      Spinal Neuroinflammation in a Rat Model of Oxaliplatin-Induced Pain.
PG  - 2052-2061
LID - 10.1007/s10753-017-0645-y [doi]
AB  - Neuroinflammatory response in spinal dorsal horn has been demonstrated to be a 
      critical factor in oxaliplatin-induced pain. Melatonin has been shown to have 
      anti-inflammatory and anti-allodynia effects in both preclinical and clinical 
      studies. In the present study, we investigated the role of systemic 
      administration of melatonin on oxaliplatin-induced pain. Intraperitoneal (i.p.) 
      injection with oxaliplatin induced significantly mechanical allodynia and thermal 
      hyperalgesia. Melatonin (i.p.) significantly alleviated mechanical allodynia and 
      thermal hyperalgesia in the oxaliplatin but not sham-treated rats. The 
      attenuation of nociceptive response persisted at least to 3 days after melatonin 
      injection, throughout the entire observing window. Immunohistochemistry showed 
      that oxaliplatin induced a significant increase of glial fibrillary acidic 
      protein (GFAP) immunodensities, which could be suppressed by melatonin. Western 
      blotting showed that GFAP protein levels were significantly elevated in the 
      oxaliplatin-vehicle group. Melatonin significantly decreased oxaliplatin-induced 
      upregulation of GFAP expressions. Oxaliplatin injection also enhanced the 
      messenger RNA (mRNA) expressions of cytokines including interleukin-1beta (IL-1beta) 
      and tumor necrosis factor-alpha (TNF-alpha) and chemokines including monocyte 
      chemoattractant protein-1 (MCP-1) and monocyte inflammatory protein-1 (MIP-1alpha) in 
      the spinal dorsal horn, which could be significantly repressed by melatonin. In 
      vitro study showed that mRNA levels of TNF-alpha, IL-1beta, MCP-1, and MIP-1alpha in 
      primarily astrocytes were significantly increased after lipopolysaccharide (LPS, 
      1 mug/ml) stimulation. Melatonin (10 and 100 muM) greatly inhibited synthesis of 
      these inflammatory mediators, in a dose-related manner. Conclusively, our data 
      provide a novel implication of anti-nociceptive mechanism of melatonin in 
      chemotherapy-related pain.
FAU - Wang, Ye-Song
AU  - Wang YS
AD  - Department of Intensive Care Unit, Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, Zhejiang, 310009, 
      China.
FAU - Li, Yuan-Yuan
AU  - Li YY
AD  - Department of Neurointensive Care Unit, Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, Zhejiang, 310009, 
      China.
FAU - Cui, Wei
AU  - Cui W
AD  - Department of Intensive Care Unit, Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, Zhejiang, 310009, 
      China.
FAU - Li, Li-Bin
AU  - Li LB
AD  - Department of Intensive Care Unit, Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, Zhejiang, 310009, 
      China.
FAU - Zhang, Zhao-Cai
AU  - Zhang ZC
AD  - Department of Intensive Care Unit, Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, Zhejiang, 310009, 
      China.
FAU - Tian, Bao-Ping
AU  - Tian BP
AD  - Department of Intensive Care Unit, Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, Zhejiang, 310009, 
      China.
FAU - Zhang, Gen-Sheng
AU  - Zhang GS
AD  - Department of Intensive Care Unit, Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, Zhejiang, 310009, 
      China. genshengzhang@zju.edu.cn.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (Inflammation Mediators)
RN  - JL5DK93RCL (Melatonin)
SB  - IM
MH  - Animals
MH  - Astrocytes/metabolism/*pathology
MH  - Inflammation/*pathology
MH  - Inflammation Mediators/antagonists & inhibitors
MH  - Melatonin/*pharmacology/therapeutic use
MH  - Pain Measurement/*drug effects
MH  - Rats
MH  - Spinal Cord/*pathology
OTO - NOTNLM
OT  - astrocyte
OT  - melatonin
OT  - neuroinflammation
OT  - neuropathic pain
OT  - oxaliplatin
EDAT- 2017/08/16 06:00
MHDA- 2018/07/11 06:00
CRDT- 2017/08/17 06:00
PHST- 2017/08/16 06:00 [pubmed]
PHST- 2018/07/11 06:00 [medline]
PHST- 2017/08/17 06:00 [entrez]
AID - 10.1007/s10753-017-0645-y [pii]
AID - 10.1007/s10753-017-0645-y [doi]
PST - ppublish
SO  - Inflammation. 2017 Dec;40(6):2052-2061. doi: 10.1007/s10753-017-0645-y.