PMID- 28812391
OWN - NLM
STAT- MEDLINE
DCOM- 20180618
LR  - 20181202
IS  - 1029-2330 (Electronic)
IS  - 1026-7158 (Linking)
VI  - 25
IP  - 9-10
DP  - 2017 Nov-Dec
TI  - pH-sensitive polymersomes: controlling swelling via copolymer structure and 
      chemical composition.
PG  - 899-909
LID - 10.1080/1061186X.2017.1363216 [doi]
AB  - pH-sensitive vesicles used as drug delivery systems (DDSs) are generally composed 
      of protonable copolymers. The disaggregation of these nanoparticles (NPs) during 
      drug release implies the dispersion of positively charged cytotoxic 
      polyelectrolytes in the human body. To alleviate such issue, we synthesised 
      A(BC)(n) amphiphilic block copolymers with linear (n = 1) and branched (n = 2) 
      architectures to obtain pH-sensitive vesicles capable of releasing drugs in 
      acidic conditions via controlled swelling instead of disaggregation. We obtained 
      this feature by fine-tuning the relative amount of pH-sensitive and hydrophobic 
      monomers. We studied pH-driven swelling by measuring NPs size in neutral and 
      acidic conditions, the latter typical of tumours or inflamed tissues (pH approximately 6) and 
      lysosomes (pH approximately 4.5). Dynamic light scattering (DLS) and zeta potential data 
      provided useful indications about the influence of architecture and chemical 
      composition on NPs swelling, stability and polycation release. Results 
      demonstrated that vesicles made of linear copolymers with  approximately 22-28% in mol of 
      protonable monomers in the 'BC' block swelled more than other species following a 
      pH change from pH 7.4 to pH 4.5. We finally evaluated the cytotoxicity of 
      vesicles composed of linear species, and paclitaxel (PTX) release from the latter 
      in both cancer and normal cells.
FAU - Villani, Simone
AU  - Villani S
AD  - a Dipartimento di Chimica e Biologia , Universita degli Studi di Salerno , 
      Fisciano , Italy.
FAU - Adami, Renata
AU  - Adami R
AD  - b Dipartimento di Ingegneria Industriale , Universita degli Studi di Salerno , 
      Fisciano , Italy.
FAU - Reverchon, Ernesto
AU  - Reverchon E
AD  - b Dipartimento di Ingegneria Industriale , Universita degli Studi di Salerno , 
      Fisciano , Italy.
FAU - Ferretti, Anna Maria
AU  - Ferretti AM
AD  - c Istituto di Scienze e Tecnologie Molecolari , Consiglio Nazionale delle 
      Ricerche , Milano , Italy.
FAU - Ponti, Alessandro
AU  - Ponti A
AD  - c Istituto di Scienze e Tecnologie Molecolari , Consiglio Nazionale delle 
      Ricerche , Milano , Italy.
FAU - Lepretti, Marilena
AU  - Lepretti M
AD  - a Dipartimento di Chimica e Biologia , Universita degli Studi di Salerno , 
      Fisciano , Italy.
FAU - Caputo, Ivana
AU  - Caputo I
AD  - a Dipartimento di Chimica e Biologia , Universita degli Studi di Salerno , 
      Fisciano , Italy.
FAU - Izzo, Lorella
AU  - Izzo L
AD  - a Dipartimento di Chimica e Biologia , Universita degli Studi di Salerno , 
      Fisciano , Italy.
LA  - eng
PT  - Journal Article
DEP - 20170816
PL  - England
TA  - J Drug Target
JT  - Journal of drug targeting
JID - 9312476
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Polymers)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - P88XT4IS4D (Paclitaxel)
SB  - IM
MH  - Antineoplastic Agents, Phytogenic/*chemistry/metabolism/pharmacology
MH  - Cell Survival/drug effects/physiology
MH  - Hep G2 Cells
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Paclitaxel/*chemistry/metabolism/pharmacology
MH  - Polyethylene Glycols/*chemistry/metabolism/pharmacology
MH  - Polymers/*chemistry/metabolism/pharmacology
OTO - NOTNLM
OT  - ATRP
OT  - controlled drug-release
OT  - pH-sensitive polymersomes
OT  - vesicles
EDAT- 2017/08/16 06:00
MHDA- 2018/06/19 06:00
CRDT- 2017/08/17 06:00
PHST- 2017/08/16 06:00 [pubmed]
PHST- 2018/06/19 06:00 [medline]
PHST- 2017/08/17 06:00 [entrez]
AID - 10.1080/1061186X.2017.1363216 [doi]
PST - ppublish
SO  - J Drug Target. 2017 Nov-Dec;25(9-10):899-909. doi: 10.1080/1061186X.2017.1363216. 
      Epub 2017 Aug 16.