PMID- 28813656
OWN - NLM
STAT- MEDLINE
DCOM- 20170928
LR  - 20181113
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 47
IP  - 2
DP  - 2017 Aug 15
TI  - Fcgamma Receptor Function and the Design of Vaccination Strategies.
PG  - 224-233
LID - S1074-7613(17)30316-3 [pii]
LID - 10.1016/j.immuni.2017.07.009 [doi]
AB  - Through specific interactions with distinct types of Fcgamma receptors (FcgammaRs), the 
      Fc domain of immunoglobulin G (IgG) mediates a wide spectrum of immunological 
      functions that influence both innate and adaptive responses. Recent studies 
      indicate that IgG Fc-FcgammaR interactions are dynamically regulated during an immune 
      response through the control of the Fc-associated glycan structure and Ig 
      subclass composition on the one hand and selective FcgammaR expression on immune 
      cells on the other, which together determine the capacity of IgG to interact in a 
      cell-type-specific manner with specific members of the FcgammaR family. Here, we 
      present a framework that synthesizes the current understanding of the 
      contribution of FcgammaR pathways to the induction and regulation of antibody and 
      T cell responses. Within this context, we discuss vaccination strategies 
      to elicit broad and potent immune responses based on the immunomodulatory 
      properties of Fc-FcgammaR interactions.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Bournazos, Stylianos
AU  - Bournazos S
AD  - Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 
      York Avenue, New York, NY 10065, USA.
FAU - Ravetch, Jeffrey V
AU  - Ravetch JV
AD  - Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 
      York Avenue, New York, NY 10065, USA. Electronic address: 
      ravetch@rockefeller.edu.
LA  - eng
GR  - P01 AI100148/AI/NIAID NIH HHS/United States
GR  - U19 AI109946/AI/NIAID NIH HHS/United States
GR  - P01 CA190174/CA/NCI NIH HHS/United States
GR  - R35 CA196620/CA/NCI NIH HHS/United States
GR  - U19 AI111825/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Immunoglobulin Fc Fragments)
RN  - 0 (Immunoglobulin Isotypes)
RN  - 0 (Receptors, IgG)
RN  - 0 (Vaccines)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Immunoglobulin Fc Fragments/*metabolism
MH  - Immunoglobulin Isotypes/immunology/*metabolism
MH  - Immunomodulation
MH  - Receptors, IgG/immunology/*metabolism
MH  - Signal Transduction
MH  - T-Lymphocytes, Regulatory/*immunology
MH  - Vaccination
MH  - Vaccines/*immunology
PMC - PMC5573140
MID - NIHMS894407
OTO - NOTNLM
OT  - antibodies
OT  - effector functions
OT  - immune regulation
OT  - immunity
OT  - immunization
OT  - therapy
OT  - vaccination
EDAT- 2017/08/17 06:00
MHDA- 2017/09/29 06:00
PMCR- 2018/08/15
CRDT- 2017/08/17 06:00
PHST- 2017/04/05 00:00 [received]
PHST- 2017/07/17 00:00 [accepted]
PHST- 2017/08/17 06:00 [entrez]
PHST- 2017/08/17 06:00 [pubmed]
PHST- 2017/09/29 06:00 [medline]
PHST- 2018/08/15 00:00 [pmc-release]
AID - S1074-7613(17)30316-3 [pii]
AID - 10.1016/j.immuni.2017.07.009 [doi]
PST - ppublish
SO  - Immunity. 2017 Aug 15;47(2):224-233. doi: 10.1016/j.immuni.2017.07.009.